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Prompt gamma-ray imaging with a nuclear emulsion for in vivo dose verification in proton therapy

Research Project

Project/Area Number 16K15349
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Medical Physics and Radiological Technology
Research InstitutionNagoya City University

Principal Investigator

TOSHITO Toshiyuki  名古屋市立大学, 大学院医学研究科, 研究員 (30377965)

Co-Investigator(Renkei-kenkyūsha) NAKAMURA Mitsuhiro  名古屋大学, 大学院理学研究科, 教授 (90183889)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Keywords医学物理学 / 陽子線治療 / 原子核乾板 / ガンマ線 / 医学物理(学) / 陽子線
Outline of Final Research Achievements

A first prototype emulsion gamma camera was tested at Nagoya Proton Therapy Center (NPTC) in Japan. The gamma camera which measures 62.5 × 50 × 3.2 mm3 was put on the sidewall of a water phantom. The camera was assembled by stacking 10 emulsion films. The phantom was irradiated with 200 MeV protons using a spot scanning nozzle at NPTC. After development of emulsion films, films were scanned by using a high-speed emulsion read-out system at Nagoya University. After a pilot analysis to localize gamma-ray events which have e+/e- pair topology in the emulsion films, a candidate event of a several-MeV gamma-ray which converts to e+/e- pair was detected.
We examined a first prototype nuclear emulsion gamma-ray camera system for proof-of-principle. The detector system operated within expectations. Our developed emulsion gamma camera confirmed its potential as a detector for emulsion SPECT system for in vivo dose verification in proton beam radiotherapy.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (8 results)

All 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (6 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] Estimation and correction of produced light from prompt gamma photons on luminescence imaging of water for proton therapy dosimetry2018

    • Author(s)
      Yabe Takuya、Komori Masataka、Toshito Toshiyuki、Yamaguchi Mitsutaka、Kawachi Naoki、Yamamoto Seiichi
    • Journal Title

      Physics in Medicine & Biology

      Volume: 63 Issue: 4 Pages: 04NT02-04NT02

    • DOI

      10.1088/1361-6560/aaa90c

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of the optical errors on the luminescence imaging of water for proton beam2018

    • Author(s)
      Yabe Takuya、Komori Masataka、Horita Ryo、Toshito Toshiyuki、Yamamoto Seiichi
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

      Volume: 888 Pages: 163-168

    • DOI

      10.1016/j.nima.2018.01.030

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Prompt gamma imaging with a nuclear emulsion for in vivo dose verification in proton therapy2018

    • Author(s)
      Toshiyuki Toshito, Mitsuhiro Kimura, Hiroyuki Ogino, Yuta Shibamoto, Mitsuhiro Nakamura, Osamu Sato
    • Organizer
      Particle Therapy Co-Operative Group (PTCOG) 56
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prompt gamma-ray imaging for particle beam therapy using nuclear emulsion2018

    • Author(s)
      Toshiyuki Toshito, Mitsuhiro Kimura, Hiroyuki Ogino, Yuta Shibamoto, Osamu Sato, Mitsuhiro Nakamura
    • Organizer
      Internal Conference on Materials and Systems for Sustainability 2017 (ICMaSS 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prompt gamma-ray imaging with a nuclear emulsion for in vivo dose verification in proton therapy2018

    • Author(s)
      Toshiyuki Toshito, Mitsuhiro Kimura, Hiroyuki Ogino, Yuta Shibamoto, Mitsuhiro Nakamura, Osamu Sato
    • Organizer
      2017 IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 粒子線がん治療の高精度化に向けた原子核乾板技術2018

    • Author(s)
      歳藤利行
    • Organizer
      日本写真学会年次大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 原子核乾板技術を用いた陽子線がん治療の高精度化にむけた研究2017

    • Author(s)
      木村充宏、歳藤利行
    • Organizer
      第31回固体飛跡検出器研究会
    • Place of Presentation
      量子科学技術研究開発機構関西光科学研究所(京都府木津川市)
    • Year and Date
      2017-03-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 原子核乾板技術で切り拓く陽子線がん治療の未来2017

    • Author(s)
      木村充宏、歳藤利行
    • Organizer
      原子核乾板技術研究発表会
    • Place of Presentation
      名古屋大学(愛知県名古屋市)
    • Year and Date
      2017-02-15
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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