Development of a At-211 imaging method with a Compton camera for targeted alpha-particle radiotherapy
| Project/Area Number |
16K15351
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology |
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Principal Investigator |
Kawachi Naoki 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 放射線生物応用研究部, 上席研究員(定常) (70414521)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAO Yuto 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 放射線生物応用研究部, 技術員 (60622545)
YAMAGUCHI Mitsutaka 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 放射線生物応用研究部, 主幹研究員 (10375404)
ISHIOKA Noriko 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 放射線生物応用研究部, 上席研究員 (30354963)
WATABE Hiroshi 国立大学法人東北大学, サイクロトロンラジオアイソトープセンター, 教授 (40280820)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | コンプトンカメラ / 標的アイソトープ治療 / At-211 / RI内用療法 |
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| Outline of Final Research Achievements |
Astatine-211 is a promising radionuclide for targeted radiotherapy. It is important to acquire an image of the distribution of targeted radiotherapeutic agents in a patient's body for optimization of treatment strategies. We proposed to image At-211 quantitatively with high-energy photons to overcome some problems in conventional planar gamma camera or single-photon emission computed tomography imaging. We performed an imaging experiment of a point-like At-211 source using a Compton camera, and demonstrated the capability of imaging At-211 with the high-energy photons for the first time.
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Report
(3 results)
Research Products
(4 results)
