Improvement of predictive power on cardiovascular disease risk by introducing ECG-gated fundus imaging system

• Project/Area Number: 16K15359
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Teikyo University
• Principal Investigator: ASAYAMA KEI 帝京大学, 医学部, 准教授 (80431518)
• Co-Investigator(Kenkyū-buntansha): 大久保 孝義 帝京大学, 医学部, 教授 (60344652) ; 坪田 恵 (宇津木恵) 岩手医科大学, 医学部, 講師 (20419998) ; 小川 充洋 帝京大学, 理工学部, 准教授 (30322085)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 生体信号同期システム / 循環器疾患リスク因子 / 眼底カメラ / 光電脈波 / 心電図 / 生体信号同期型眼底カメラシステム / 大迫研究 / MMSE / IDACO / 食事頻度調査 / 眼底動静脈径 / 心電計同期型眼底カメラシステム / 国際比較

Outline of Final Research Achievements

We first developed a prototype fundus camera system, which is synchronized with an electrocardiograph, to measure the diameter of fundus arteriovenous vessels.
The improvement in accuracy based on the system was not as great as we had expected; it would be because the period to reach the ocular arteriovenous artery from the heart varies very much. We therefore developed a new photoelectric pulse wave measuring device based on a new idea that led to a patent application, in order to measure the point where is closer to the fundus. There was a good correlation between photoelectric pulse wave and heartbeat. Although the device was not made available for a field research in the Japanese general population during the study period, the use of precise fundus index measurements enables a more precise quantitative assessment of risk factors for cardiovascular disease as well as cognitive dysfunction.

Academic Significance and Societal Importance of the Research Achievements

循環器疾患の発症予測には、正確なリスク因子の把握が重要である。本研究は、リスク因子のうち眼底カメラによって撮影される眼底動静脈の脈管径などの指標に着目し、先行研究で指摘されているこれらの精度の低さを克服する手段として、心電計に同期、続いて光電脈波に同期させた撮影法により眼底指標の測定精度向上を図った。本成果の発展的適用によって、循環器疾患リスク因子の一層厳密な評価が可能になると期待される。

Research Products

• [Int'l Joint Research] KU Leuven(ベルギー)
• [Int'l Joint Research] KU Leuven(ベルギー)
• [Int'l Joint Research] KU Leuven(Belgium)
• [Int'l Joint Research] KU Leuven(Belgium)
• [Journal Article] N-Terminal Pro-B-Type Natriuretic Peptide Is a Predictor of Chronic Kidney Disease in an Asian General Population ― The Ohasama Study ― (2020)
  • Author(s): Nakayama Shingo、Satoh Michihiro、Metoki Hirohito、Murakami Takahisa、Asayama Kei、Hara Azusa、Hirose Takuo、Inoue Ryusuke、Tsubota-Utsugi Megumi、Kikuya Masahiro、Mori Takefumi、Hozawa Atsushi、Node Koichi、Imai Yutaka、Ohkubo Takayoshi
  • Journal Title: Circulation Reports Volume: 2 Issue: 1 Pages: 24-32
  • DOI: 10.1253/circrep.CR-19-0044
  • NAID: 130007784351
  • ISSN: 2434-0790
  • Year and Date: 2020-01-10
  • Peer Reviewed / Open Access
• [Journal Article] Age-Related Trends in Home Blood Pressure, Home Pulse Rate, and Day-to-Day Blood Pressure and Pulse Rate Variability Based on Longitudinal Cohort Data: The Ohasama Study (2019)
  • Author(s): Satoh Michihiro、Metoki Hirohito、Asayama Kei、Murakami Takahisa、Inoue Ryusuke、Tsubota‐Utsugi Megumi、Matsuda Ayako、Hirose Takuo、Hara Azusa、Obara Taku、Kikuya Masahiro、Nomura Kyoko、Hozawa Atsushi、Imai Yutaka、Ohkubo Takayoshi
  • Journal Title: Journal of the American Heart Association Volume: 8 Issue: 15
  • DOI: 10.1161/jaha.119.012121
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Outcome-Driven Thresholds for Ambulatory Blood Pressure Based on the New American College of Cardiology/American Heart Association Classification of Hypertension (2019)
  • Author(s): Cheng YB, Thijs L, Zhang ZY, Kikuya M, Yang WY, Melgarejo JD, Boggia J, Wei FF, Hansen TW, Yu CG, Asayama K, Ohkubo T, Dolan E, Stolarz-Skrzypek K, Malyutina S, Casiglia E, Lind L, Filipovsky J, Maestre GE, Imai Y, Kawecka-Jaszcz K, Sandoya E, Narkiewicz K, Li Y, O'Brien E, Wang JG, Staessen JA.
  • Journal Title: Hypertension Volume: 74 Issue: 4 Pages: 776
  • DOI: 10.1161/hypertensionaha.119.13512
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association of Office and Ambulatory Blood Pressure with Mortality and Cardiovascular Outcomes (2019)
  • Author(s): Yang WY, Melgarejo JD, Thijs L, Zhang ZY, Boggia J, Wei FF, Hansen TW, Asayama K, Ohkubo T, Jeppesen J, Dolan E, Stolarz-Skrzypek K, Malyutina S, Casiglia E, Lind L, Filipovsky J, Maestre GE, Li Y, Wang JG, Imai Y, Kawecka-Jaszcz K, Sandoya E, Narkiewicz K, O'Brien E, Verhamme P, Staessen JA.
  • Journal Title: JAMA Volume: 322 Issue: 5 Pages: 409
  • DOI: 10.1001/jama.2019.9811
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Opposing age-related trends in absolute and relative risk of adverse health outcomes associated with out-of-office blood pressure (2019)
  • Author(s): Li Y, Thijs L, Zhang ZY, Asayama K, et al.
  • Journal Title: Hypertension Volume: 74 Issue: 6 Pages: 1333
  • DOI: 10.1161/hypertensionaha.119.12958
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Stroke risk due to partial white-coat or masked hypertension based on the ACC/AHA guideline’s blood pressure threshold: the Ohasama study (2019)
  • Author(s): Satoh M, Asayama K, Murakami T, Kikuya M, Metoki H, Imai Y, Ohkubo T.
  • Journal Title: Hypertension Research Volume: 42 Issue: 1 Pages: 120
  • DOI: 10.1038/s41440-018-0133-2
  • Peer Reviewed
• [Journal Article] Evidence-based proposal for the number of ambulatory readings required for assessing blood pressure level in research settings: an analysis of the IDACO database (2018)
  • Author(s): Yang WY, Thijs L, Zhang ZY, Asayama K, Boggia J, Hansen TW, Ohkubo T, Jeppesen J, Stolarz-Skrzypek K, Malyutina S, Casiglia E, Nikitin Y, Li Y, Wang JG, Imai Y, Kawecka-Jaszcz K, O'Brien E, Staessen JA.
  • Journal Title: Blood Pressure Volume: 27 Issue: 6 Pages: 341
  • DOI: 10.1080/08037051.2018.1476057
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Predictive power of home blood pressure indices at baseline and during follow-up in hypertensive patients: HOMED-BP study (2018)
  • Author(s): Watabe D, Asayama K, Hanazawa T, Hosaka M, Satoh M, Yasui D, Obara T, Inoue R, Metoki H, Kikuya M, Imai Y, Ohkubo T.
  • Journal Title: Hypertension Research Volume: 41 Issue: 8 Pages: 622
  • DOI: 10.1038/s41440-018-0050-4
  • Peer Reviewed
• [Journal Article] Reproducibility of Retinal Microvascular Traits Decoded by the Singapore i Vessel Assessment Software Across the Human Age Range (2018)
  • Author(s): Huang QF, Wei FF, Zhang ZY, Raaijmakers A, Asayama K, Thijs L, Yang WY, Mujaj B, Allegaert K, Verhamme P, Struijker-Boudier HAJ, Li Y, Staessen JA.
  • Journal Title: American Journal of Hypertension Volume: 31 Issue: 4 Pages: 438
  • DOI: 10.1093/ajh/hpx202
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nocturnal blood pressure decline based on different time intervals and long-term cardiovascular risk: the Ohasama Study (2018)
  • Author(s): Satoh M, Asayama K, Kikuya M, Inoue R, Tsubota-Utsugi M, Obara T, Murakami K, Matsuda A, Murakami T, Nomura K, Metoki H, Imai Y, Ohkubo T.
  • Journal Title: Clin Exp Hypertens Volume: 40 Issue: 1 Pages: 1
  • DOI: 10.1080/10641963.2016.1259324
  • Peer Reviewed
• [Journal Article] Home blood pressure predicts stroke incidence among older adults with impaired physical function: The Ohasama study (2017)
  • Author(s): Murakami K, Asayama K, Satoh M, Hosaka M, Matsuda A, Inoue R, Tsubota-Utsugi M, Murakami T, Nomura K, Kikuya M, Metoki H, Imai Y, Ohkubo T.
  • Journal Title: J Hypertens. Volume: 35 Issue: 12 Pages: 2395
  • DOI: 10.1097/hjh.0000000000001473
  • Peer Reviewed
• [Journal Article] Prevalence, Treatment, and Control Rates of Conventional and Ambulatory Hypertension Across 10 Populations in 3 Continents (2017)
  • Author(s): Melgarejo JD, Maestre GE, Thijs L, Asayama K, Boggia J, Casiglia E, Hansen TW, Imai Y, Jacobs L, Jeppesen J, Kawecka-Jaszcz K, Kuznetsova T, Li Y, Malyutina S, Nikitin Y, Ohkubo T, Stolarz-Skrzypek K, Wang JG, Staessen JA, IDACO Investigators.
  • Journal Title: Hypertension Volume: 70 Issue: 1 Pages: 50
  • DOI: 10.1161/hypertensionaha.117.09188
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Outcome-Driven Thresholds for Increased Home Blood Pressure Variability (2017)
  • Author(s): Juhanoja EP, Niiranen TJ, Johansson JK, Puukka PJ, Thijs L, Asayama K, Langen VL, Hozawa A, Aparicio LS, Ohkubo T, Tsuji I, Imai Y, Stergiou GS, Jula AM, Staessen JA, IDHOCO Investigators.
  • Journal Title: 10.1161/HYPERTENSIONAHA.117.09188 Volume: 69 Issue: 4 Pages: 599
  • DOI: 10.1161/hypertensionaha.116.08603
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Lacunar Infarcts Rather than White Matter Hyperintensity as a Predictor of Future Higher Level Functional Decline: The Ohasama Study (2017)
  • Author(s): Tsubota-Utsugi M, Satoh M, Tomita N, Hara A, Kondo T, Hosaka M, Saito S, Asayama K, Inoue R, Hirano M, Hosokawa A, Murakami K, Murakami T, Metoki H, Kikuya M, Izumi SI, Imai Y, Ohkubo T.
  • Journal Title: J Stroke Cerebrovasc Dis. Volume: 26 Issue: 2 Pages: 376
  • DOI: 10.1016/j.jstrokecerebrovasdis.2016.09.036
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Retinal microvascular diameter, a hypertension-related trait, in ECG-gated vs. non-gated images analyzed by IVAN and SIVA (2016)
  • Author(s): Wei FF, Zhang ZY, Petit T, Cauwenberghs N, Gu YM, Thijs L, Raaijmakers A, Jacobs L, Yang WY, Allegaert K, Kuznetsova T, Verhamme P, Struijker-Boudier HA, Li Y, Asayama K, Staessen JA.
  • Journal Title: Hypertens Res Volume: 39 Issue: 12 Pages: 886
  • DOI: 10.1038/hr.2016.81
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Menstrual Factors and Stroke Incidence in Japanese Postmenopausal Women: The Ohasama Study (2016)
  • Author(s): Murakami K, Metoki H, Satoh M, Asayama K, Hosaka M, Matsuda A, Inoue R, Tsubota-Utsugi M, Murakami T, Nomura K, Kikuya M, Imai Y, Ohkubo T.
  • Journal Title: Neuroepidemiology Volume: 47 Issue: 2 Pages: 109
  • DOI: 10.1159/000452220
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 眼底所見と認知機能の関連：大迫研究 (2019)
  • Author(s): 須賀明子、布施恵子、佐藤倫広、浅山敬、小林信一朗、世古俊明、山中珠美、松本知沙、菊谷昌浩、野村恭子、井上茂、今井潤、大久保孝義
  • Organizer: 第29回日本疫学会学術総会
• [Presentation] 白衣高血圧と左室肥大の関連における家庭血圧レベルの影響：大迫研究 (2019)
  • Author(s): 奈良井 大輝、佐藤 倫広、村上 任尚、菊地 ひかり、中山 晋吾、高畠 恭介、廣瀬 卓男、佐藤 和奏、浅山 敬、菊谷 昌浩、野村 恭子、寳澤 篤、目時 弘仁、今井 潤、大久保 孝義
  • Organizer: 第８回臨床高血圧フォーラム
• [Presentation] 都市部未来型コホート構築論研究 (2019)
  • Author(s): 浅山 敬、中西 穂高、古川 泰司、大久保 孝義、菊谷 昌浩、内田 俊也
  • Organizer: 第2回帝京大学研究交流シンポジウム
• [Presentation] 度歯周病罹患歯の保有数と血圧との関連―大迫研究― (2019)
  • Author(s): 村上任尚、佐藤倫広、小宮山貴将、大井孝、遠藤耕生、平塚貴子、浅山敬、菊谷昌浩、井上隆輔、坪田恵、目時弘仁、寶澤篤、今井潤、服部佳功、大久保孝義
  • Organizer: 第31回血圧管理研究会
• [Presentation] Risk charts based on out-of-the-office blood pressure measurement (2019)
  • Author(s): Kei Asayama
  • Organizer: IDACO/IDHOCO/IDCARS Consortium Meeting 2019
  • Int'l Joint Research
• [Presentation] Home blood pressure variability based on the routine self-measurement. (2018)
  • Author(s): Kei Asayama
  • Organizer: Pulse of Asia (POA) 2018
  • Int'l Joint Research / Invited
• [Presentation] 血圧の測定と評価における問題点 (2018)
  • Author(s): 浅山 敬
  • Organizer: 第7回臨床高血圧フォーラム
  • Invited
• [Presentation] Prognostic relevance of seasonal blood pressure changes (2018)
  • Author(s): Kei Asayama
  • Organizer: Seasonal and Altitude Variation in Blood Pressure: Evidence, Consensus and Recommendation for Clinical Practice
  • Int'l Joint Research / Invited
• [Presentation] 外来高血圧患者における自動診察室・家庭・通常診察室血圧の関連の検討 (SPRINT-J パイロット試験)背景と経緯 (2018)
  • Author(s): 大久保孝義、浅山 敬
  • Organizer: 第41回日本高血圧学会総会
  • Invited
• [Presentation] 血圧測定法の違いによる血圧変動性と循環器疾患リスク (2018)
  • Author(s): 浅山 敬
  • Organizer: 第41回日本高血圧学会総会
  • Invited
• [Presentation] Practical Use of Self-measured Home Blood Pressure. (2018)
  • Author(s): Kei Asayama
  • Organizer: Hypertension Beijing 2018 meeting
  • Int'l Joint Research / Invited
• [Presentation] 血圧日内・日間変動と脳心血管疾患のリスク (2017)
  • Author(s): 浅山敬
  • Organizer: 第87回日本衛生学会
  • Invited
• [Presentation] Nocturnal blood pressure (2017)
  • Author(s): Kei Asayama
  • Organizer: The 27th European Meeting on Hypertension and Cardiovascular Protection
  • Int'l Joint Research / Invited
• [Presentation] 24時間自由行動下血圧測定の重要性 (2017)
  • Author(s): 浅山敬
  • Organizer: 第37回日本ホルター・ノンインベイシブ心電学研究会
  • Invited
• [Presentation] Significance of self-measured home blood pressure -- a Japanese perspective (2017)
  • Author(s): Kei Asayama
  • Organizer: Ready for 2018 -- The 6th China International Forum on Hypertension
  • Int'l Joint Research / Invited
• [Presentation] From mercury sphygmomanometer to electric device on blood pressure measurement (2017)
  • Author(s): Kei Asayama
  • Organizer: 2017 Sprint Meeting of Korean Clinical Hypertension Society
  • Int'l Joint Research / Invited
• [Presentation] 最適な血圧測定法と降圧治療開始時期を考える (2017)
  • Author(s): 浅山敬、大久保孝義
  • Organizer: 第40回日本高血圧学会総会
  • Invited
• [Presentation] 家庭血圧測定とコホート研究 (2016)
  • Author(s): 淺山敬
  • Organizer: 第86回日本衛生学会
  • Place of Presentation: 旭川市民文化会館 (北海道旭川市)
  • Year and Date: 2016-05-11
• [Presentation] Significance of self-measured home blood pressure in management of hypertension. (2016)
  • Author(s): Kei Asayama
  • Organizer: Hypertension Summit 2016
  • Place of Presentation: ホテルグランヴィア京都 (京都府京都市)
  • Int'l Joint Research / Invited
• [Presentation] Prognostic significance of self-measured home blood pressure (2016)
  • Author(s): Kei Asayama
  • Organizer: MOVE symposium
  • Place of Presentation: MVL Hotel (Yeosu, Korea)
  • Invited
• [Presentation] 家庭血圧値は身体機能レベルが低下した高齢者においても脳卒中発症を予測する: 大迫研究 (2016)
  • Author(s): 村上慶子,浅山敬,佐藤倫広,井上隆輔,坪田恵,松田彩子,野村恭子,村上任尚,菊谷昌浩,目時弘仁,今井潤,大久保孝義
  • Organizer: 第39回日本高血圧学会総会
  • Place of Presentation: 仙台国際センター (宮城県仙台市)
• [Presentation] 家庭血圧・脈拍値と日間変動の加齢に伴う推移 ―大迫研究― (2016)
  • Author(s): 佐藤倫広、浅山敬, 菊谷昌浩、井上隆輔、芳賀俊和、坪田(宇津木)恵、小原拓、村上慶子、松田彩子、村上任尚、野村恭子、目時弘仁、今井潤、大久保孝義
  • Organizer: 第28回血圧管理研究会
  • Place of Presentation: メルパルク京都 (京都府京都市)
• [Book] Health Issues and Care System for the Elderly (2019)
  • Author(s): Asayama K, Ohkubo T.
  • Total Pages: 196
  • Publisher: Springer, Singapore
  • ISBN: 9789811317613
• [Patent(Industrial Property Rights)] OCULAR FUNDUS IMAGING SYSTEM, DISEASE ONSET RISK PREDICTION METHOD, AND OCULAR FUNDUS IMAGING METHOD (2019)
  • Inventor(s): 浅山 敬、小川 充洋、松田 浩幸、Jan Staessen
  • Industrial Property Rights Holder: 浅山 敬、小川 充洋、松田 浩幸、Jan Staessen
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019
  • Overseas
• [Patent(Industrial Property Rights)] 眼底撮影システム、疾患発症リスク予測方法、および眼底撮影方法 (2017)
  • Inventor(s): 浅山敬、小川充洋、松田浩幸
  • Industrial Property Rights Holder: 浅山敬、小川充洋、松田浩幸
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017