Role of ILC2 in the formation of maternal allergic inflammation and allergic susceptibility of the offspring
Project/Area Number |
16K15362
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Epidemiology and preventive medicine
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Research Institution | Institute of Physical and Chemical Research |
Principal Investigator |
Moro Kazuyo 国立研究開発法人理化学研究所, 統合生命医科学研究センター, チームリーダー (90468489)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | ILC2 / アレルギー / 予防 / 自然リンパ球 |
Outline of Final Research Achievements |
We examined the distribution of ILC2 and found that ILC2 exist in the uterus and placenta of pregnant mice. While there was a low number of ILC2 in the uterus of non-pregnant mice, they increased during pregnancy. Moreover, induction of allergic inflammation in pregnant mice by administration of IL-33 further increased the number of ILC2 in the uterus and placenta, suggesting ILC2 in these organs play an important role in induction of type 2 immune responses during pregnancy, raising the possibility that maternal allergic inflammation affects allergic susceptibility of the offspring via ILC2. Next, we administrated IL-33 into female mice, and after pregnancy and delivery, we examined cell populations and cytokine production in the lung and BALF of their offspring. We found that the numbers of ILC2 and eosinophils in the lung were increased and high amounts of IL-5 were detected in the BALF of offspring derived from IL-33-treated mothers.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes.2017
Author(s)
Kojo S, Tanaka H, Endo TA, Muroi S, Liu Y, Seo W, Tenno M, Kakugawa K, Naoe Y, Nair K, Moro K, Katsuragi Y, Kanai A, Inaba T, Egawa T, Venkatesh B, Minoda A, Kominami R, Taniuchi I.
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Journal Title
Nat Commun.
Volume: 8
Issue: 1
Pages: 702-702
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] 2型自然リンパ球の役割2016
Author(s)
茂呂和世
Organizer
第44回日本臨床免疫学会総会
Place of Presentation
東京都新宿区京王プラザホテル
Year and Date
2016-09-08
Related Report
Invited
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