| Project/Area Number |
16K15377
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Iizumi Yosuke 京都府立医科大学, 医学(系)研究科(研究院), 助教 (20533178)
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| Research Collaborator |
Imai Ayaka 京都府立医科大学, 大学院医学研究科, 大学院生
Goi Wakana 京都府立医科大学, 大学院医学研究科, 研究補助員
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | APOBEC3B / がん予防 / 天然化合物 / スクリーニング / 癌予防 / 天然由来化合物 / 遺伝子変異 / 食品成分 |
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| Outline of Final Research Achievements |
As an achievement of cancer genome projects, a cellular enzyme, APOBEC3B, has been reported to be a critical cause of mutations found in various cancers. In this study, we performed the screening for natural compounds which contribute to cancer prevention by decreasing APOBEC3B. As a result, we found two natural compounds which can downregulate APOBEC3B at the mRNA level, whereas these compounds could not decrease APOBEC3B at the protein level.
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