| Project/Area Number |
16K15383
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | Chubu University |
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Principal Investigator |
NASU Tamie 中部大学, 生命健康科学部, 特任教授 (10020794)
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| Co-Investigator(Kenkyū-buntansha) |
山ノ下 理 中部大学, 生命健康科学部, 講師 (50424924)
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| Research Collaborator |
WANG hailan
YUAN yuan
KAMIJIMA michihiro
ITO yuki
NAITO hisao
KAWAMOTO yoshiyuki
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | トリクロロエチレン / Hypersensitivity / CYP2E1抗体 / 性差 / 喫煙 / 飲酒 / 皮膚病型 / 疫学研究 / IgG / ELISA / 自己抗体 / 免疫沈降 / CYP2E1 / HLA多型 |
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| Outline of Final Research Achievements |
We recruited 67 blood samples of trichloroethylene (TCE)-induced hypersensitivity syndrome (HS) patients, those of sex- and age-matched TCE HS-tolerant control and TCE non-exposed control, respectively. Serum CYP2E1 antibody was measured in each group using ELISA method. In men, the value of TCE HS-tolerant control was higher than that of TCE non-exposed control, while no difference was observed between the antibody levels of the former and patient group. In women, although the value of TCE HS-tolerant control was higher than that of TCE non-exposed control, that of patient group was lower than the TCE HS-tolerant control group, and no difference was observed between patients and TCE non-exposed group. Smoking and drinking habits did not affect TCE-induced serum CYP2E1 antibody in both sexes.
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| Academic Significance and Societal Importance of the Research Achievements |
TCEによるHSはHLA-B*の遺伝子多型によって頻度が変わる。HLA-B*13：01はTCE HSの感受性遺伝子であり、この多型が多い中国や東南アジアでの発生頻度が多い。しかし発生頻度が少ないとはいえ、わが国でも発症している。これは作業環境のTCEをもっと低める必要性があると同時にHS発症のメカニズムを明らかにすることの重要性を示す。この研究はHSがTCE曝露約28日後に発症することにヒントを得て、TCEによるHS発症のメカニズムが明らかにすることが目的である。学術的に意義あることであり、予防につながるので社会的意義が大きい。
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