Investigation for metabolic features in divergency of ageing
| Project/Area Number |
16K15412
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 老化 / メタボライト |
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| Outline of Final Research Achievements |
Human aging is a highly complex biological process exhibiting great individual variation. While distinguishing young and elderly people visually is easy and intuitive, it is still not possible to distinguish human blood samples from young and elderly donors. Nonetheless, chemical biology holds great promise for identifying age-related metabolites, quantitatively and qualitatively.
Our deliberate exclusion of middle-aged donors from the study gave us a clearer age-difference between young (average; 29yr) and elderly (average; 81yr). The combination of comprehensive CV (coefficient of variation) analysis and RBC (red blood cell) metabolomics enabled us to identify 51 previously unreported metabolite CVs. Ultimately, we presented evidence that a small number of blood samples (N=30) clearly indicated 14 possible age-related metabolites. Six of these 14 candidates are RBC-enriched, suggesting that RBC metabolomics is highly valuable.
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Report
(2 results)
Research Products
(7 results)
