| Project/Area Number |
16K15417
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 交感神経 / 転移 / 炎症性サイトカイン / 転移前微小環境 / がん / 交感神経β受容体遮断薬 / βブロッカー / 自律神経 |
|---|
| Outline of Final Research Achievements |
The researcher investigated the functional relationship between the sympathetic nervous system and metastasis. The researcher found that the sympathetic nervous system partially contributed to angiogenesis, cell proliferation, and establishment of pre-metastatic niche in lungs. Moreover, tyrosine hydroxylase-positive neurons physically interacted with immunocompetent cells, and beta adrenergic agonists induced gene expression of inflammatory cytokines.
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