Development of a simple frail index that can be used in the office
| Project/Area Number |
16K15419
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Ehime University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | フレイル / サルコペニア / 動脈スティフネス / 身体的フレイル / 精神・心理的フレイル / 脳微小血管病 / 認知機能低下 / 握力 / 開眼片足立ち / 軽度認知機能障害 / 認知機能障害 / 臓器障害 / 老化 / 内科 / 生理学 / リハビリテーション |
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| Outline of Final Research Achievements |
We have developed a simple physical flail assessment method that can be used in the office. A simple index that combines reduced grip strength and shortened one-leg standing time with eyes open was associated with various physical, mental and psychological frail factors such as cognitive function, respiratory function, muscle mass, sway of the center of gravity, and arteriosclerosis index. Furthermore, we have demonstrated that it can be used as a tool for screening for mild cognitive decline (MCI). By adding vital capacity, body sway, and arterial stiffness, the diagnostic accuracy of MCI could be further increased. Based on the results of the study, it is conceivable that physical frailty, mental/psychological frailty, and social frail are related to each other by high arterial stiffness as a common underlying mechanism.
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| Academic Significance and Societal Importance of the Research Achievements |
診察室で特別な機器を必要としない身体的フレイルの評価が可能になることで、日常臨床におけるフレイルのスクリーニングが容易になる。さらに、本簡易指標が軽度認知機能低下(MCI)とも関連することから、認知機能テストを行わず、MCIのスクリーニングが可能になる。これは、特に認知機能テストを受けることに抵抗がある例に有用である。動脈スティフネスの亢進が、身体的、精神・心理的、社会的フレイルの共通の要因であることが明らかになったことより、動脈硬化の予防がフレイル予防の戦略となる可能性がある。
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Report
(5 results)
Research Products
(52 results)
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[Journal Article] Hyperglycemia in non-obese patients with type 2 diabetes is associated with low muscle mass: The MUSCLES-DM study.2019
Author(s)
Sugimoto K, Tabara Y, Ikegami H, Takata Y, Kamide K, Ikezoe T, Kiyoshige E, Makutani Y, Onuma H, Gondo Y, Ikebe K, Ichihashi N, Tsuboyama T, Matsuda F, Kohara K, Kabayama M, Fukuda M, Katsuya T, Osawa H, Hiromine Y, Rakugi H.
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Journal Title
J Diabetes Investig.
Volume: 10:
Issue: 6
Pages: 1471-1479
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] High central blood pressure is associated with incident cardiovascular events in treated hypertensives: the ABC-J II Study.2018
Author(s)
Eguchi K, Miyashita H, Takenaka T, Tabara Y, Tomiyama H, Dohi Y, Hashimoto J, Ohkubo T, Ohta Y, Hirooka Y, Kohara K, Ito S, Kawano Y, Sunagawa K, Takazawa K, Yamashina A, Shimada K.
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Journal Title
Hypertension Research
Volume: 41
Issue: 11
Pages: 947-956
DOI
Related Report
Peer Reviewed
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[Journal Article] A double-blind, placebo-controlled, randomised clinical study of the effect of pork collagen peptide supplementation on atherosclerosis in healthy older individuals.2018
Author(s)
Igase M, Kohara K, Okada Y, Ochi M, Igase K, Inoue N, Kutsuna T, Miura H, Ohyagi Y.
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Journal Title
Biosci Biotechnol Biochem.
Volume: 2
Issue: 5
Pages: 1-3
DOI
Related Report
Peer Reviewed
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[Journal Article] Dual Effects of a RETN Single Nucleotide Polymorphism (SNP) at -420 on Plasma Resistin: Genotype and DNA Methylation.2017
Author(s)
Onuma H, Tabara Y, Kawamura R, Ohashi J, Nishida W, Takata Y, Ochi M, Nishimiya T, Ohyagi Y, Kawamoto R, Kohara K, Miki T, Osawa H.
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Journal Title
J Clin Endocrinol Metab.
Volume: 102
Issue: 3
Pages: 884-892
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] A genome-wide association study of plasma resistin levels identified rs1423096 and rs10401670 as possible functional variants in the Japanese population.2016
Author(s)
Kawamura R, Tabara Y, Tsukada A, Igase M, Ohashi J, Yamada R, Takata Y, Kawamoto R, Saito I, Onuma H, Tanigawa T, Yamada K, Kato N, Ohyagi Y, Miki T, Kohara K, Osawa H.
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Journal Title
Physiol Genomics.
Volume: 48
Issue: 11
Pages: 874-881
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Diabetic mice exhibited a peculiar alteration in body composition with exaggerated ectopic fat deposition after muscle injury due to anomalous cell differentiation.2016
Author(s)
Mogi M, Kohara K, Nakaoka H, Kan-No H, Tsukuda K, Wang XL, Chisaka T, Bai HY, Shan BS, Kukida M, Iwanami J, Miki T, Horiuchi M
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Journal Title
J Cachexia Sarcopenia Muscle
Volume: 7
Issue: 2
Pages: 213-224
DOI
Related Report
Peer Reviewed / Open Access
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