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Development of a simple frail index that can be used in the office

Research Project

Project/Area Number 16K15419
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionEhime University

Principal Investigator

Kohara Katsuhiko  愛媛大学, 社会共創学部, 教授 (30260384)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywordsフレイル / サルコペニア / 動脈スティフネス / 身体的フレイル / 精神・心理的フレイル / 脳微小血管病 / 認知機能低下 / 握力 / 開眼片足立ち / 軽度認知機能障害 / 認知機能障害 / 臓器障害 / 老化 / 内科 / 生理学 / リハビリテーション
Outline of Final Research Achievements

We have developed a simple physical flail assessment method that can be used in the office. A simple index that combines reduced grip strength and shortened one-leg standing time with eyes open was associated with various physical, mental and psychological frail factors such as cognitive function, respiratory function, muscle mass, sway of the center of gravity, and arteriosclerosis index. Furthermore, we have demonstrated that it can be used as a tool for screening for mild cognitive decline (MCI). By adding vital capacity, body sway, and arterial stiffness, the diagnostic accuracy of MCI could be further increased. Based on the results of the study, it is conceivable that physical frailty, mental/psychological frailty, and social frail are related to each other by high arterial stiffness as a common underlying mechanism.

Academic Significance and Societal Importance of the Research Achievements

診察室で特別な機器を必要としない身体的フレイルの評価が可能になることで、日常臨床におけるフレイルのスクリーニングが容易になる。さらに、本簡易指標が軽度認知機能低下(MCI)とも関連することから、認知機能テストを行わず、MCIのスクリーニングが可能になる。これは、特に認知機能テストを受けることに抵抗がある例に有用である。動脈スティフネスの亢進が、身体的、精神・心理的、社会的フレイルの共通の要因であることが明らかになったことより、動脈硬化の予防がフレイル予防の戦略となる可能性がある。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (52 results)

All 2020 2019 2018 2017 2016

All Journal Article (33 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 33 results,  Open Access: 11 results,  Acknowledgement Compliant: 9 results) Presentation (12 results) (of which Int'l Joint Research: 4 results,  Invited: 11 results) Book (7 results)

  • [Journal Article] Identification of type 2 diabetes loci in 433,540 East Asian individuals.2020

    • Author(s)
      Spracklen CN, Kohara K, et al.
    • Journal Title

      Nature

      Volume: 印刷中

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Creatinine to Cystatin C Ratio as a Marker of Bone Property in Older Adults: The J-SHIPP Study.2020

    • Author(s)
      Tabara Yasuharu, Kohara Katsuhiko, Okada Yoko, Ohyagi Yasumasa, Igase Michiya
    • Journal Title

      J Nutr Health Aging

      Volume: 24 Issue: 3 Pages: 227-281

    • DOI

      10.1007/s12603-020-1315-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Creatinine-to-cystatin C ratio as a marker of skeletal muscle mass in older adults: J-SHIPP study2019

    • Author(s)
      Tabara Yasuharu、Kohara Katsuhiko、Okada Yoko、Ohyagi Yasumasa、Igase Michiya
    • Journal Title

      Clinical Nutrition

      Volume: in press Issue: 6 Pages: 1857-1862

    • DOI

      10.1016/j.clnu.2019.07.027

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)2019

    • Author(s)
      Umemura Satoshi、Arima Hisatomi、Arima Shuji、et al. (45名中13番目)
    • Journal Title

      Hypertension Research

      Volume: 42 Issue: 9 Pages: 1235-1481

    • DOI

      10.1038/s41440-019-0284-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyperglycemia in non-obese patients with type 2 diabetes is associated with low muscle mass: The MUSCLES-DM study.2019

    • Author(s)
      Sugimoto K, Tabara Y, Ikegami H, Takata Y, Kamide K, Ikezoe T, Kiyoshige E, Makutani Y, Onuma H, Gondo Y, Ikebe K, Ichihashi N, Tsuboyama T, Matsuda F, Kohara K, Kabayama M, Fukuda M, Katsuya T, Osawa H, Hiromine Y, Rakugi H.
    • Journal Title

      J Diabetes Investig.

      Volume: 10: Issue: 6 Pages: 1471-1479

    • DOI

      10.1111/jdi.13070

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distribution of cerebral microbleeds in the East and West2019

    • Author(s)
      Yakushiji Yusuke、Wilson Duncan、Ambler Gareth、et al.
    • Journal Title

      Neurology

      Volume: 92 Issue: 10 Pages: 1086-1097

    • DOI

      10.1212/wnl.0000000000007039

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Relationship between sleep-disordered breathing and central systolic blood pressure in a community-based population: the Toon Health Study.2019

    • Author(s)
      Igami K, Maruyama K, Tomooka K, Ikeda A, Tabara Y, Kohara K, Saito I, Tanigawa T.
    • Journal Title

      Hypertens Res

      Volume: 42 Issue: 7 Pages: 1074-1082

    • DOI

      10.1038/s41440-019-0219-5

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Steno-stiffness approach for cardiovascular disease risk assessment in primary prevention2019

    • Author(s)
      Tomiyama H, Kohara K, et al.
    • Journal Title

      Hypertension

      Volume: 73 Issue: 3 Pages: 508

    • DOI

      10.1161/hypertensionaha.118.12110

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interethnic analyses of blood pressure loci in populations of East Asian and European descent2018

    • Author(s)
      Takeuchi F, Kohara K, et al.
    • Journal Title

      Nat Commun.

      Volume: 9 Issue: 1 Pages: 5052-5052

    • DOI

      10.1038/s41467-018-07345-0

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] High central blood pressure is associated with incident cardiovascular events in treated hypertensives: the ABC-J II Study2018

    • Author(s)
      Eguchi K, Miyashita H, Takenaka T, Tabara Y, Tomiyama H, Dohi Y, Hashimoto J, Ohkubo T, Ohta Y, Hirooka Y, Kohara K, Ito S, Kawano Y, Sunagawa K, Takazawa K, Yamashina A, Shimada K.
    • Journal Title

      Hypertension Research

      Volume: 41 Issue: 11 Pages: 947

    • DOI

      10.1038/s41440-018-0075-8

    • URL

      https://pure.teikyo.jp/en/publications/d841c02c-bfe7-41af-9758-9ac1f0a67f0f

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Habitual hot water bathing protects cardiovascular function in middle-aged to elderly Japanese subjects.2018

    • Author(s)
      Kohara K, Tabara Y, Ochi M, Okada Y, Ohara M, Nagai T, Ohyagi Y, Igase M.
    • Journal Title

      Sci Rep.

      Volume: 8 Issue: 1 Pages: 8687-8687

    • DOI

      10.1038/s41598-018-26908-1

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population: class FormattedString { value: An individual participant data meta-analysis }2018

    • Author(s)
      Ohkuma T, Kohara K, et al.
    • Journal Title

      Atherosclerosis.

      Volume: 275 Pages: 141

    • DOI

      10.1016/j.atherosclerosis.2018.05.048

    • URL

      https://localhost/en/publications/61a2a3c8-7a76-4c29-9de3-91524ba80bcc

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Simultaneously measured interarm blood pressure difference and stroke: An individual participants data meta-analysis2018

    • Author(s)
      Tomiyama H, Kohara K, et al.
    • Journal Title

      Hypertension

      Volume: 71 Issue: 6 Pages: 1030

    • DOI

      10.1161/hypertensionaha.118.10923

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Correlation between the 24-h urinary angiotensinogen or aldosterone level and muscle mass: Japan shimanami health promoting program study.2018

    • Author(s)
      Mogi M. Kohara K. Tabara Y. Tsukuda K. Igase M. Horiuchi M.
    • Journal Title

      Hypertens Res.

      Volume: in press Issue: 5 Pages: 326-333

    • DOI

      10.1038/s41440-018-0021-9

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of an elevated ankle-brachial index differs depending on the amount of appendicular muscle mass: the J-SHIPP and Nagahama studies.2018

    • Author(s)
      Tabara Y. Igase M. Setoh K. Kawaguchi T. Okada Y. Ohara M. Takahashi Y. Kosugi S. Ohyagi Y. Miki T. Nakayama T. Kohara K. Matsuda F. J-SHIPP and Nagahama study groups.
    • Journal Title

      Hypertens Res.

      Volume: in press Issue: 5 Pages: 354-362

    • DOI

      10.1038/s41440-018-0020-x

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] A double-blind, placebo-controlled, randomised clinical study of the effect of pork collagen peptide supplementation on atherosclerosis in healthy older individuals.2018

    • Author(s)
      Igase M, Kohara K, Okada Y, Ochi M, Igase K, Inoue N, Kutsuna T, Miura H, Ohyagi Y.
    • Journal Title

      Biosci Biotechnol Biochem.

      Volume: 2 Issue: 5 Pages: 1-3

    • DOI

      10.1080/09168451.2018.1434406

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis2017

    • Author(s)
      Wheeler E, Kohara K, et al.
    • Journal Title

      PLoS Med.

      Volume: 14 Issue: 9 Pages: e1002383-e1002383

    • DOI

      10.1371/journal.pmed.1002383

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Proposed Cutoff Value of Brachial-Ankle Pulse Wave Velocity for the Management of Hypertension2017

    • Author(s)
      Ohkuma T, Kohara K, et al.
    • Journal Title

      Circulation Journal

      Volume: 81 Issue: 10 Pages: 1540-1542

    • DOI

      10.1253/circj.CJ-17-0636

    • NAID

      130006099930

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brachial-Ankle Pulse Wave Velocity and the Risk Prediction of Cardiovascular Disease An Individual Participant Data Meta-Analysis2017

    • Author(s)
      Ohkuma T, Kohara K, et al.
    • Journal Title

      Hypertension

      Volume: 69 Issue: 6 Pages: 1045

    • DOI

      10.1161/hypertensionaha.117.09097

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Office-based simple frailty score and central blood pressure predict mild cognitive impairment in an apparently healthy Japanese population: J-SHIPP study.2017

    • Author(s)
      Ohara M, Kohara K, Okada Y, Ochi M, Nagai T, Ohyagi Y, Tabara Y, Igase M.
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 46419-46419

    • DOI

      10.1038/srep46419

    • NAID

      120006305755

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Muscle mass decline, arterial stiffness, white matter hyperintensity, and cognitive impairment: Japan Shimanami Health Promoting Program study.2017

    • Author(s)
      Kohara K, Okada Y, Ochi M, Ohara M, Nagai T, Tabara Y, Igase M.
    • Journal Title

      J Cachexia Sarcopenia Muscle.

      Volume: - Issue: 4 Pages: 557-566

    • DOI

      10.1002/jcsm.12195

    • NAID

      120006822491

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cross-sectional study of equol producer status and cognitive impairment in older adults.2017

    • Author(s)
      Igase M, Igase K, Tabara Y, Ohyagi Y, Kohara K
    • Journal Title

      Geriatr Gerontol Int.

      Volume: - Issue: 11 Pages: 2103-2108

    • DOI

      10.1111/ggi.13029

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Dual Effects of a RETN Single Nucleotide Polymorphism (SNP) at -420 on Plasma Resistin: Genotype and DNA Methylation.2017

    • Author(s)
      Onuma H, Tabara Y, Kawamura R, Ohashi J, Nishida W, Takata Y, Ochi M, Nishimiya T, Ohyagi Y, Kawamoto R, Kohara K, Miki T, Osawa H.
    • Journal Title

      J Clin Endocrinol Metab.

      Volume: 102 Issue: 3 Pages: 884-892

    • DOI

      10.1210/jc.2016-2417

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Skin Autofluorescence Examination as a Diagnostic Tool for Mild Cognitive Impairment in Healthy People.2017

    • Author(s)
      Igase M, Ohara M, Igase K, Kato T, Okada Y, Ochi M, Tabara Y, Kohara K, Ohyagi Y.
    • Journal Title

      J Alzheimers Dis.

      Volume: 55 Issue: 4 Pages: 1481-1487

    • DOI

      10.3233/jad-160917

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Office-based simple frailty score and central blood pressure predict mild cognitive impairment in an apparently healthy Japanese population: J-SHIPP study.2017

    • Author(s)
      Ohara M, Kohara K, Okada Y, Ochi M, Nagai T, Ohyagi Y, Tabara Y, Igase M.
    • Journal Title

      Sci Reports

      Volume: in press

    • NAID

      120006305755

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] B-type natriuretic peptide is a determinant of the nocturnal increase in blood pressure independently of arterial hypertrophy and hypoxia.2016

    • Author(s)
      Tabara Y, Igase M, Miki T, Ohyagi Y, Matsuda F, Kohara K
    • Journal Title

      J Hypertens.

      Volume: 34 Issue: 12 Pages: 2293-2401

    • DOI

      10.1097/hjh.0000000000001104

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study of plasma resistin levels identified rs1423096 and rs10401670 as possible functional variants in the Japanese population2016

    • Author(s)
      Kawamura R, Tabara Y, Tsukada A, Igase M, Ohashi J, Yamada R, Takata Y, Kawamoto R, Saito I, Onuma H, Tanigawa T, Yamada K, Kato N, Ohyagi Y, Miki T, Kohara K, Osawa H.
    • Journal Title

      Physiol Genomics.

      Volume: 48 Issue: 11 Pages: 874

    • DOI

      10.1152/physiolgenomics.00040.2016

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Mendelian randomization analysis in three Japanese populations supports a causal role of alcohol consumption in lowering low-density lipid cholesterol levels and particle numbers.2016

    • Author(s)
      Tabara Y, Ueshima H, Takashima N, Hisamatsu T, Fujiyoshi A, Zaid M, Sumi M, Kohara K, Miki T, Miura K; SESSA Research Group; J-SHIPP Study Group.
    • Journal Title

      Atherosclerosis.

      Volume: 254 Pages: 242-248

    • DOI

      10.1016/j.atherosclerosis.2016.08.021

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Diabetic mice exhibited a peculiar alteration in body composition with exaggerated ectopic fat deposition after muscle injury due to anomalous cell differentiation.2016

    • Author(s)
      Mogi M, Kohara K, Nakaoka H, Kan-No H, Tsukuda K, Wang XL, Chisaka T, Bai HY, Shan BS, Kukida M, Iwanami J, Miki T, Horiuchi M
    • Journal Title

      J Cachexia Sarcopenia Muscle

      Volume: 7 Issue: 2 Pages: 213-224

    • DOI

      10.1002/jcsm.12044

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Orthostatic hypertension as a predisposing factor for masked hypertension: the J-SHIPP study.2016

    • Author(s)
      Tabara Y, Igase M, Miki T, Ohyagi Y, Matsuda F, Kohara K; J-SHIPP study group.
    • Journal Title

      Hypertens Res.

      Volume: 39 Issue: 9 Pages: 664-669

    • DOI

      10.1038/hr.2016.43

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Association of office-based frailty score with hypertensive end organ damage in the J-SHIPP cross-sectional study.2016

    • Author(s)
      Tabara Yasuharu, Katsuhiko Kohara, Masayuki Ochi, Yoko Okada, Maya Ohara, Tokihisa Nagai, Michiya Igase
    • Journal Title

      International Journal of Cardiology

      Volume: 216 Pages: 25-31

    • DOI

      10.1016/j.ijcard.2016.04.135

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Usefulness of the second derivative of the finger photoplethysmogram for assessment of end-organ damage: the J-SHIPP study.2016

    • Author(s)
      Tabara Y, Igase M, Okada Y, Nagai T, Miki T, Ohyagi Y, Matsuda F, Kohara K.
    • Journal Title

      HYPERTENSION RESEARCH

      Volume: 印刷中 Issue: 7 Pages: 552-556

    • DOI

      10.1038/hr.2016.18

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synergistic association of changes in serum uric acid and triglycerides with changes in insulin resistance after walking exercise in community-dwelling older women.2016

    • Author(s)
      Kawamoto R, Katoh T, Ninomiya D, Kumagi T, Abe M, Kohara K.
    • Journal Title

      Endocr Res.

      Volume: 41 Pages: 116-123

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 高齢者の降圧薬治療は認知機能との関係でどのような注意が必要か.2019

    • Author(s)
      小原克彦
    • Organizer
      第42回日本高血圧学会総会.
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 認知症2019

    • Author(s)
      小原克彦
    • Organizer
      第8回 臨床高血圧フォーラム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] JSH2019に基づく高血圧治療について2019

    • Author(s)
      小原克彦
    • Organizer
      第49回 中国四国大学保健管理研究集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] サルコペニアとフレイルの最前線. 動脈スティフネスを中心として2019

    • Author(s)
      小原克彦
    • Organizer
      第84回 日本体力医学会中国・四国地方会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Clinical characteristics of frailty-related MCI2018

    • Author(s)
      Kohara Katsuhiko
    • Organizer
      14th International Symposium of Geriatrics and Gerontology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] サルコペニアと動脈硬化2018

    • Author(s)
      小原克彦
    • Organizer
      第5回 日本サルコペニア・フレイル学会大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 認知機能障害やフレイルを有する高齢者高血圧患者の治療2018

    • Author(s)
      小原克彦
    • Organizer
      第60回日本老年医学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 高齢者の特徴と高齢者高血圧2018

    • Author(s)
      小原克彦
    • Organizer
      第41回日本高血圧学会総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 自立した高齢者における身体的フレイルの臨床的特徴:簡易フレイルスコアを用いた検討2017

    • Author(s)
      小原克彦
    • Organizer
      第40回 日本高血圧学会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Frailty-related MCI in the general population and its clinical characteristics2017

    • Author(s)
      Kohara K, et al.
    • Organizer
      XXIII World Congress of Neurology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Arterial stiffness, central BP and sarcopenia2016

    • Author(s)
      Katsuhiko Kohara
    • Organizer
      2nd Asian Conference for Frailty and Sarcopenia
    • Place of Presentation
      Imaike Gas Building (Aichi, Nagoya)
    • Year and Date
      2016-11-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Elderly hypertension: not the chronology but the pathophysiology2016

    • Author(s)
      Katsuhiko Kohara
    • Organizer
      The 26th Scientific Meeting of International society of hypertension
    • Place of Presentation
      Seoul (Korea)
    • Year and Date
      2016-09-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Book] 循環器の高齢者診療術2019

    • Author(s)
      小原克彦、他
    • Total Pages
      254
    • Publisher
      南江堂
    • ISBN
      9784524246458
    • Related Report
      2019 Annual Research Report
  • [Book] 高血圧診療ステップアップ2019

    • Author(s)
      小原克彦、他
    • Total Pages
      294
    • Publisher
      診断と治療者
    • ISBN
      9784787824028
    • Related Report
      2019 Annual Research Report
  • [Book] 高血圧治療ガイドライン20192019

    • Author(s)
      小原克彦、他
    • Total Pages
      304
    • Publisher
      ライフサイエンス社
    • ISBN
      9784897753867
    • Related Report
      2019 Annual Research Report
  • [Book] 現場のお悩みズバリ解決!循環器の高齢者診療“術”2019

    • Author(s)
      小原克彦 他
    • Total Pages
      262
    • Publisher
      南江堂
    • ISBN
      9784524246458
    • Related Report
      2018 Research-status Report
  • [Book] 高血圧診療 ステップアップ2019

    • Author(s)
      小原克彦 他
    • Total Pages
      294
    • Publisher
      診断と治療社
    • ISBN
      9784787824028
    • Related Report
      2018 Research-status Report
  • [Book] 高血圧治療ガイドライン 20192019

    • Author(s)
      小原克彦 他
    • Total Pages
      281
    • Publisher
      ライフサイエンス出版
    • Related Report
      2018 Research-status Report
  • [Book] リハ栄養からアプローチするサルコペニアバイブル2018

    • Author(s)
      山本直史、小原克彦(分担)
    • Total Pages
      217
    • Publisher
      日本医事新報社
    • ISBN
      9784784947263
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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