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Nrd1 as a novel therapeutic target against colorectal cancer

Research Project

Project/Area Number 16K15427
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionKyoto University

Principal Investigator

Seno Hiroshi  京都大学, 医学研究科, 教授 (90335266)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords大腸癌 / 癌 / 大腸 / マウス
Outline of Final Research Achievements

Nrd1 activates extracellular ADAM proteases, and regulates the nuclear activity of HDAC in coordination with NCoR/SMRT. In this study, we investigated the mechanisms in which Nrd1 promotes colorectal cancer. First, we determined the expression of various growth factors and cytokines in the intestinal tumors in Nrd1 KO and Nrd1 floxed mice. Next, we also examined functional association among Nrd1, HDAC, and p53 in human colon cancer cells and tumor spheroids. These experiments suggest that Nrd1 may be a novel therapeutic target against colorectal cancer.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (14 results)

All 2018 2017 2016

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Acknowledgement Compliant: 3 results,  Open Access: 2 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Updated Trends in Gallbladder and Other Biliary Tract Cancers Worldwide2018

    • Author(s)
      Matsumoto Tomonori、Seno Hiroshi
    • Journal Title

      Clinical Gastroenterology and Hepatology

      Volume: 16 Issue: 3 Pages: 339-340

    • DOI

      10.1016/j.cgh.2017.11.034

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical sequencing using a next-generation sequencing-based multiplex gene assay in patients with advanced solid tumors2017

    • Author(s)
      Kou Tadayuki、Kanai Masashi、Yamamoto Yoshihiro、Kamada Mayumi、Nakatsui Masahiko、Sakuma Tomohiro、Mochizuki Hiroaki、Hiroshima Akinori、Sugiyama Aiko、Nakamura Eijiro、Miyake Hidehiko、Minamiguchi Sachiko、Takaori Kyoichi、Matsumoto Shigemi、Haga Hironori、Seno Hiroshi、Kosugi Shinji、Okuno Yasushi、Muto Manabu
    • Journal Title

      Cancer Science

      Volume: 108 Issue: 7 Pages: 1440-1446

    • DOI

      10.1111/cas.13265

    • NAID

      120006333897

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine2017

    • Author(s)
      Goto Norihiro、Ueo Taro、Fukuda Akihisa、Kawada Kenji、Sakai Yoshiharu、Miyoshi Hiroyuki、Taketo Makoto Mark、Chiba Tsutomu、Seno Hiroshi
    • Journal Title

      Cancer Research

      Volume: 77 Issue: 13 Pages: 3442-3454

    • DOI

      10.1158/0008-5472.can-16-3192

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Proliferating EpCAM-Positive Ductal Cells in the Inflamed Liver Give Rise to Hepatocellular Carcinoma2017

    • Author(s)
      Matsumoto Tomonori、Takai Atsushi、Eso Yuji、Kinoshita Kazuo、Manabe Toshiaki、Seno Hiroshi、Chiba Tsutomu、Marusawa Hiroyuki
    • Journal Title

      Cancer Research

      Volume: 77 Issue: 22 Pages: 6131-6143

    • DOI

      10.1158/0008-5472.can-17-1800

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nardilysin regulates inflammation, metaplasia, and tumors in murine stomach2017

    • Author(s)
      Kimura Y, Ikuta K, Kimura T, Chiba T, Oshima H, Oshima M, *Nishi E, *Seno H
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 43052-43052

    • DOI

      10.1038/srep43052

    • NAID

      120006355734

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pathogenicity of Immunoglobulin G in Patients with IgG4-related Disease.2016

    • Author(s)
      Shiokawa M, Kodama Y, Kuriyama K, Yoshimura K, Tomono T, Morita T, Kakiuchi N, Matsumori T, Mima A, Nishikawa Y, Ueda T, Tsuda M, Yamauchi Y, Minami R, Sakuma Y, Ota Y, Maruno T, Kurita A, Sawai Y, Tsuji Y, Uza N, Matsumura K, Watanabe T, Notohara K, Tsuruyama T, Seno H, Chiba T.
    • Journal Title

      Gut

      Volume: 未定 Issue: 8 Pages: 3292-3301

    • DOI

      10.1136/gutjnl-2015-310336

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling.2016

    • Author(s)
      Takada Y, Fukuda A, Chiba T, Seno H.
    • Journal Title

      Development

      Volume: 143 Pages: 3532-3539

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] The role of Hes1 in the normal and tumor stem cells of the intestine.2017

    • Author(s)
      Norihiro Goto, Akihisa Fukuda, Tsutomu Chiba, Hiroshi Seno
    • Organizer
      American Association for Cancer Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 代謝、炎症、発癌を制御する因子Nardilysinの可能性2017

    • Author(s)
      生田耕三、福田晃久、妹尾浩
    • Organizer
      第103回日本消化器病学会総会内第1回消化器臓器間ネットワーク附置研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Nrdc inhibtits Kras-driven pancreatic tumorigenesis through suppressing spontaneous pancreatitis2017

    • Author(s)
      Kozo Ikuta,Akihisa Fukuda,Tomoyuki Tsuda,Takahisa Maruno,Keitaro Kanda,Eiichiro Nishi,Hiroshi Seno
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Nardilysin functions as a tumor suppressor in pancreatic ductal adenocarcinoma through maintaining acinar cell differentiation and suppressing pancreatitis2017

    • Author(s)
      Kozo Ikuta, Akihisa Fukuda, Hiroshi Seno
    • Organizer
      JDDW 2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] BRG1はSox9の発現制御を介しPanINの形成・維持に重要な役割をはたす2017

    • Author(s)
      津田喬之、福田晃久、妹尾
    • Organizer
      JDDW 2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Brg1 plays an important role in acinar cell-derived PanIN formation through regulation of SOX9 expression.2016

    • Author(s)
      Tsuda M, Fukuda A, Chiba T, Seno H.
    • Organizer
      Digestive Disease Week 2016
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-05-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 消化器腫瘍における腫瘍幹細胞標的治療2016

    • Author(s)
      妹尾浩、丸野貴久、後藤規弘、福田晃久
    • Organizer
      第75回日本癌学会総会
    • Place of Presentation
      横浜 パシフィコ横浜
    • Related Report
      2016 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2019-03-29  

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