Nrd1 as a novel therapeutic target against colorectal cancer
| Project/Area Number |
16K15427
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto University |
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Principal Investigator |
Seno Hiroshi 京都大学, 医学研究科, 教授 (90335266)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 大腸癌 / 癌 / 大腸 / マウス |
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| Outline of Final Research Achievements |
Nrd1 activates extracellular ADAM proteases, and regulates the nuclear activity of HDAC in coordination with NCoR/SMRT. In this study, we investigated the mechanisms in which Nrd1 promotes colorectal cancer. First, we determined the expression of various growth factors and cytokines in the intestinal tumors in Nrd1 KO and Nrd1 floxed mice. Next, we also examined functional association among Nrd1, HDAC, and p53 in human colon cancer cells and tumor spheroids. These experiments suggest that Nrd1 may be a novel therapeutic target against colorectal cancer.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Pathogenicity of Immunoglobulin G in Patients with IgG4-related Disease.2016
Author(s)
Shiokawa M, Kodama Y, Kuriyama K, Yoshimura K, Tomono T, Morita T, Kakiuchi N, Matsumori T, Mima A, Nishikawa Y, Ueda T, Tsuda M, Yamauchi Y, Minami R, Sakuma Y, Ota Y, Maruno T, Kurita A, Sawai Y, Tsuji Y, Uza N, Matsumura K, Watanabe T, Notohara K, Tsuruyama T, Seno H, Chiba T.
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Journal Title
Gut
Volume: 未定
Issue: 8
Pages: 3292-3301
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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