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Basic research for the study of NASP as a background of pancreatic cancer

Research Project

Project/Area Number 16K15428
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionOsaka University

Principal Investigator

Kamada Yoshihiro  大阪大学, 医学系研究科, 准教授 (30622609)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsNASP / NASH / Mac-2 binding protein / 脂肪酸 / 膵線維化 / Mac-2bp / 慢性膵炎 / 膵がん
Outline of Final Research Achievements

We investigated the pathological change of pancreas in some mouse NASH models. Among these models, methionine choline deficient (MCD) diet administration induced inflammatory and fatty change in mouse pancreas as mouse steatohepatitis progression.
In human chronic pancreatitis patients, we found serum Mac-2 binding protein (Mac-2bp) as a useful biomarker for the diagnosis of chronic pancreatitis. We already have found that Mac-2bp is a useful biomarker for NASH in both human and mouse. Considering together, we hypothesize that Mac-2bp is a key molecule between NASH and NASP. To elucidate the role of Mac-2bp in NASH and NASP, we recently succeeded to establish Mac-2bp knockout mice.
Fatty acid (palmitic acid, oleic acid) induced inflammatory and fibrogenic cytokine production in pancreatic stellate cell, and this inflammatory and fibrogenic change accelerated the pathophysiological change of pancreatic cancer.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report

Research Products

(43 results)

All 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] Targeting the mevalonate pathway is a novel therapeutic approach to inhibit oncogenic FoxM1 transcription factor in human hepatocellular carcinoma.2018

    • Author(s)
      Ogura S, Yoshida Y, Kurahashi T, Egawa M, Furuta K, Kiso S, Kamada Y, Hikita H, Eguchi H, Ogita H, Doki Y, Mori M, Tatsumi T, Takehara T.
    • Journal Title

      Oncotarget

      Volume: in press

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment of an antibody specific for cancer-associated haptoglobin: a possible implication of clinical investigation2018

    • Author(s)
      Nishino K, Koda S, Kataoka N, Takamatsu S, Nakano M, Ikeda S, Kamamatsu Y, Morishita K, Moriwaki K, Eguchi H, Yamamoto E, Kikkawa F, Tomita Y, Kamada Y, Miyoshi E.
    • Journal Title

      Oncotarget

      Volume: 29 Pages: 12732-12744

    • DOI
      10.18632/oncotarget.24332
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 肥満の及ぼす人体への影響~特にアディポサイトカイン~2018

    • Author(s)
      鎌田佳宏、三善英知、竹原徹郎
    • Journal Title

      消化器・肝臓内科

      Volume: 3 Pages: 153-160

    • Related Report
      2017 Annual Research Report
  • [Journal Article] A practical approach to pancreatic cancer immunotherapy using resected tumor lysate vaccines processed to express α-gal epitopes.2017

    • Author(s)
      Hata T, Kawamoto K, Eguchi H, Kamada Y, Takamatsu S, Maekawa T, Nagaoka S, Yamada D, Iwagami Y, Asaoka T, Noda T, Wada H, Gotoh K, Masamune A, Miyoshi E, Mori M, Doki Y.
    • Journal Title

      PLoS One.

      Volume: 46 Pages: 1259-1266

    • DOI
      10.1097/mpa.0000000000000943
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mac-2 Binding Protein is a Useful Liver Fibrosis Biomarker for NAFLD/NASH2017

    • Author(s)
      Kamada Y and Miyoshi E.
    • Journal Title

      TIGG

      Volume: 29 Issue: 170 Pages: E85-E92

    • DOI
      10.4052/tigg.1714.1E
    • NAID
      130006219286
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of Mac-2 binding protein as a biomarker for nonalcoholic fatty liver disease diagnosis2017

    • Author(s)
      Kamada Y, Ono M, Hyogo H, Fujii H, Sumida Y, Yamada M, Mori K, Tanaka S, Maekawa T, Ebisutani Y, Yamamoto A, Takamatsu S, Yoneda M, Kawada N, Chayama K, Saibara T, Takehara T, Miyoshi E.; Japan Study Group of NAFLD (JSG-NAFLD)
    • Journal Title

      Hepatol Commun

      Volume: 1 Pages: 780-791

    • DOI
      10.1002/hep4.1080
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reevaluation of Pholiota squarrosa lectin-reactive haptoglobin as a pancreatic cancer biomarker using an improved ELISA system.2017

    • Author(s)
      Kusama K, Okamoto Y, Saito K, Kasahara T, Murata T, Ueno Y, Kobayashi Y, Kamada Y, Miyoshi E.
    • Journal Title

      Glycoconj J

      Volume: 34 Pages: 537-544

    • DOI
      10.1007/s10719-017-9772-9
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum WFA+ -M2BP levels predict liver fibrosis, development of hepatocellular carcinoma, and overall survival: A meta-analysis.2017

    • Author(s)
      Ito K, Murotani K, Nakade Y, Inoue T, Nakao H, Sumida Y, Kamada Y, Yoneda M.
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: 32 Pages: 1922-1930

    • DOI
      10.1111/jgh.13802
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel pathogenesis of inflammatory bowel disease from the perspective of glyco-immunology.2017

    • Author(s)
      Shinzaki S, Iijima H, Fujii H, Kamada Y, Naka T, Takehara T, Miyoshi E.
    • Journal Title

      J Biochem.

      Volume: 印刷中 Pages: 409-415

    • DOI
      10.1093/jb/mvx010
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of α1,6-fucosyltransferase inhibitors through the diversity-oriented syntheses of GDP-fucose mimics using the coupling between alkyne and sulfonyl azide.2017

    • Author(s)
      Manabe, Y., Kasahara, S., Takakura, Y., Yang, X., Takamatsu, S., Kamada Y., Miyoshi, M., Yoshidome, D., Fukasea, K.
    • Journal Title

      Bioorg Med Chem.

      Volume: 25 Pages: 2844-2850

    • DOI
      10.1016/j.bmc.2017.02.036
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of Forkhead box M1 transcription factor is associated with clinicopathological features and confers a poor prognosis in human hepatocellular carcinoma2017

    • Author(s)
      Egawa M, Yoshida Y, Ogura S, Kurahashi T, Kizu T, Furuta K, Kamada Y, Chatani N, Hamano M, Kiso S, Hikita H, Tatsumi T, Eguchi H, Nagano H, Doki Y, Mori M, Takehara T
    • Journal Title

      Hepatology Research

      Volume: 印刷中 Pages: 1196-1205

    • DOI
      10.1111/hepr.12854
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Establishment of mouse Mac-2 binding protein enzyme-linked immunosorbent assay and its application for mouse chronic liver disease models.2017

    • Author(s)
      Iwata A, Kamada Y, Ebisutani Y, Yamamoto A, Ueda Y, Arai H, Fujii H, Takamatsu S, Maruyama N, Maeda M, Takehara T, Miyoshi E.
    • Journal Title

      Hepatol Res.

      Volume: 47 Pages: 1-11

    • DOI
      10.1111/hepr.12819
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] メタボがんの高危険群囲い込みのための血液バイオマーカーによる非侵襲的診断方法開発2017

    • Author(s)
      鎌田佳宏、三善英知
    • Journal Title

      臨床病理

      Volume: 7 Pages: 778-785

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肝疾患の糖鎖バイオマーカー2017

    • Author(s)
      鎌田佳宏、三善英知
    • Journal Title

      BIO Clinica

      Volume: 4 Pages: 33-37

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Hepatic aberrant glycosylation by N-acetylglucosaminyltransferase V accelerates HDL assembly.2016

    • Author(s)
      Kamada Y, Kida S, Hirano KI, Yamaguchi S, Suzuki A, Hashimoto C, Kimura A, Sato M, Fujii H, Sobajima T, Yamamoto A, Ebisutani Y, Takamatsu S, Shinzaki S, Yoshida Y, Yamada M, Nagasaka H, Takehara T, Miyoshi E.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol.

      Volume: 311

    • DOI
      10.1152/ajpgi.00231.2016
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Application of glycoscience to the early detection of pancreatic cancer.2016

    • Author(s)
      Miyoshi E, Kamada Y
    • Journal Title

      Cancer Sci.

      Volume: 107 Pages: 1357-1362

    • DOI
      10.1111/cas.13011
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Core-fucosylation plays a pivotal role in hepatitis B pseudo virus infection: a possible implication for HBV glycotherapy2016

    • Author(s)
      Takamatsu S, Shimomura M, Kamada Y, Maeda H, Sobajima T, Hikita H, Iijima M, Okamoto Y, Misaki R, Fujiyama K, Nagamori S, Kanai Y, Takehara T, Ueda K, Kuroda S, Miyoshi E.
    • Journal Title

      Glycobiology

      Volume: 26 Pages: 1180-1189

    • DOI
      10.1093/glycob/cww067
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Core Fucosylation on T cells, Required for Activation of T-cell Receptor Signaling and Induction of Colitis in Mice, is Increased in Patients with Inflammatory Bowel Disease.2016

    • Author(s)
      Maekawa T*, Kamada Y* (equally contributed), Ebisutani Y, Ueda M, Hata T, Kawamoto K, Takamatsu S, Mizutani K, Shimomura M, Sobajima T, Fujii H, Nakayama K, Nishino K, Yamada M, Kumada T, Ito T, Eguchi H, Nagano H, Miyoshi E.
    • Journal Title

      World J Gastroenterol.

      Volume: 22 Pages: 4403-10

    • DOI
      10.3748/wjg.v22.i17.4403
    • NAID
      40021255019
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Core Fucosylation on T cells, Required for Activation of T-cell Receptor Signaling and Induction of Colitis in Mice, is Increased in Patients with Inflammatory Bowel Disease2016

    • Author(s)
      Fujii H, Shinzaki S, Iijima H, Wakamatsu K, Iwamoto C, Sobajima T, Kuwahara R, Hiyama S, Hayashi Y, Takamatsu S, Uozumi N, Kamada Y, Tsujii M, Taniguchi N, Takehara T, Miyoshi E
    • Journal Title

      Gastroenterology.

      Volume: 未定 Pages: 00297-3

    • DOI
      10.1053/j.gastro.2016.03.002
    • NAID
      40021255019
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A glycoproteomic approach to identify novel glycomarkers for cancer stem cells.2016

    • Author(s)
      Sawanobori A, Moriwaki K, Takamatsu S, Kamada Y, Miyoshi E.
    • Journal Title

      Proteomics

      Volume: 16 Pages: 3073-3080

    • DOI
      10.1002/pmic.201500472
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of plasma transaminase levels on the peripheral blood glutamate levels and memory functions in healthy subjects.2016

    • Author(s)
      Kamada Y, Hashimoto R, Yamamori H, Yasuda Y, Takehara T, Fujita Y, Hashimoto K, Miyoshi E.
    • Journal Title

      BBA Clin

      Volume: 5 Pages: 101-107

    • DOI
      10.1016/j.bbacli.2016.02.004
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Site-specific and linkage analyses of fucosylated N-glycans on haptoglobin in sera of patients with various types of cancer: possible implication for the differential diagnosis of cancer.2016

    • Author(s)
      Takahashi S, Sugiyama T, Shimomura M, Kamada Y, Fujita K, Nonomura N, Miyoshi E, Nakano M.
    • Journal Title

      Glycoconj J.

      Volume: 33 Pages: 471-481

    • DOI
      10.1007/s10719-016-9653-7
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Specific increase in serum core-fucosylated haptoglobin in patients with chronic pancreatitis.2016

    • Author(s)
      Ueda M, Kamada Y, Takamatsu S, Shimomura M, Maekawa T, Sobajima T, Fujii H, Nakayama K, Nishino K, Yamada M, Kobayashi Y, Kumada T, Ito T, Eguchi H, Nagano H, Miyoshi E.
    • Journal Title

      Pancreatology.

      Volume: 16 Pages: 238-243

    • DOI
      10.1016/j.pan.2016.01.004
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Gab1 adaptor protein acts as a gatekeeper to balance hepatocyte death and proliferation during acetaminophen-induced liver injury in mice.2016

    • Author(s)
      Furuta K, Yoshida Y, Ogura S, Kurahashi T, Kizu T, Maeda S, Egawa M, Chatani N, Nishida K, Nakaoka Y, Kiso S, Kamada Y, Takehara T.
    • Journal Title

      Hepatology.

      Volume: 63 Pages: 1340-1355

    • DOI
      10.1002/hep.28410
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Elevation of CA19-9 related novel marker, Core 1 Sialyl Lewis A, in sera of adenocarcinoma patients verified by a SRM based method.2016

    • Author(s)
      Tanaka-Okamoto M, Yabu M, Mukai M, Takahashi H, Fujiwara Y, Ohue M, Kamada Y, Miyoshi E, Miyamoto Y.
    • Journal Title

      J Proteome Res

      Volume: 15 Pages: 152-165

    • DOI
      10.1021/acs.jproteome.5b00893
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey2016

    • Author(s)
      Tokushige K, Hyogo H, Nakajima T, Ono M, Kawaguchi T, Honda K, Eguchi Y, Nozaki Y, Kawanaka M, Tanaka S, Imajo K, Sumida Y, Kamada Y, Fujii H, Suzuki Y, Kogiso T, Karino Y, Munekage K, Kuromatsu R, Oeda S, Yanase M, Mori K, Ogawa Y, Seko Y, Takehara T, Itoh Y, Nakajima A, Kanemasa K, Saibara T
    • Journal Title

      J Gastroenterol.

      Volume: 印刷中 Pages: 586-596

    • DOI
      10.1007/s00535-015-1129-1
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of aberrant IgG glycosylation in the pathogenesis of inflammatory bowel disease2016

    • Author(s)
      Miyoshi E, Shinzaki S, Fujii H, Iijima H, Kamada Y, Takehara T.
    • Journal Title

      Proteomics Clin Appl

      Volume: 未定 Pages: 357-369

    • DOI
      10.1002/prca.201500089
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] N-Acetylglucosaminyltransferase V (GnT-V) exacerbates murine colitis with macrophage dysfunction and enhances colitic tumorigenesis2016

    • Author(s)
      Shinzaki S, Ishii M, Fujii H, Iijima H, Wakamatsu K, Kawai S, Shiraishi E, Hiyama S, Inoue T, Hayashi Y, Kuwahara R, Takamatsu S, Kamada Y, Morii E, Tsujii M, Takehara T, Miyoshi E.
    • Journal Title

      J Gastroenterol

      Volume: 51 Pages: 357-369

    • DOI
      10.1007/s00535-015-1119-3
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ectopic expression of N-acetylglucosaminyl transferase V (GnT-V) accelerates hepatic triglyceride synthesis.2016

    • Author(s)
      Kamada Y, Ebisutani Y, Kida S, Mizutani K, Akita M, Yamamoto A, Fujii H, Sobajima T, Terao N, Takamatsu S, Yoshida Y, Takehara T, Miyoshi E
    • Journal Title

      Hepatol Res

      Volume: 46 Pages: 1189-129

    • DOI
      10.1111/hepr.12541
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] マウスMac-2bpの測定系開発と発現制御に関する検討2017

    • Author(s)
      鎌田佳宏、竹原徹郎、三善英知
    • Organizer
      第103回日本消化器病学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Biomarkers for NAFLD/NASH2017

    • Author(s)
      Yoshihiro Kamada, Tetsuo Takehara, Eiji Miyoshi
    • Organizer
      The 103rd General Meeting of the Japanese Society of Gastroenterology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] NAFLD病態進展におけるMac-2 binding proteinの意義について2017

    • Author(s)
      鎌田佳宏、竹原徹郎、三善英知
    • Organizer
      第53回日本肝臓学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] NAFLD診断におけるMac-2 binding proteinの有用性について2017

    • Author(s)
      鎌田佳宏、竹原徹郎、三善英知
    • Organizer
      日本消化器病学会近畿支部第107回例会
    • Related Report
      2017 Annual Research Report
  • [Presentation] NASH診療におけるMac-2 binding proteinとM2BPGiの比較検討2017

    • Author(s)
      鎌田佳宏、竹原徹郎、三善英知
    • Organizer
      JDDW 2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] コアフコシル化の肝細胞コレステロール代謝における役割2017

    • Author(s)
      鎌田佳宏、竹原徹郎、三善英知
    • Organizer
      第42回日本肝臓学会西部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 7.Establishment of mouse Mac-2 binding protein ELISA and its application for mouse chronic liver disease models.2017

    • Author(s)
      Yoshihiro Kamada, Ayumi Iwata, Yusuke Ebisutani, Akiko Yamamoto, Yui Ueda, Hitomi Arai, Hironobu Fujii, Shinji Takamatsu, Nobuhiro Maruyama, Masahiro Maeda, Tetsuo Takehara, Eiji Miyoshi
    • Organizer
      The 68 th Annual Meeting of the American Association for the Study of Liver Diseases
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] コアフコースを標的とした糖鎖治療法開発の基礎的検討2016

    • Author(s)
      鎌田佳宏、竹原徹郎、三善英知
    • Organizer
      第41回日本肝臓学会東部会
    • Place of Presentation
      京王プラザホテル 東京
    • Year and Date
      2016-12-08
    • Related Report
      2016 Research-status Report
  • [Presentation] Impact of plasma transaminase levels on the peripheral blood glutamate levels and memory functions in healthy subjects2016

    • Author(s)
      Yoshihiro Kamada, Ryota Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Tetsuo Takehara, Yuko Fujita, Kenji Hashimoto, Eiji Miyoshi
    • Organizer
      The 67 th Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      Boston, U.S.A.
    • Year and Date
      2016-11-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Roles of Mac-2 binding protein in the NASH liver fibrosis progression2016

    • Author(s)
      Yusuke Ebisutani, Yoshihiro Kamada, Akiko Yamamoto, Shun Ikeda, Hitomi Arai, Ayumi Iwata, Eiji Miyoshi. et al.
    • Organizer
      The 67 th Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      Boston, U.S.A.
    • Year and Date
      2016-11-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Mac-2 binding proteinのNASHバイオマーカーとしての意義2016

    • Author(s)
      鎌田佳宏、竹原徹郎、三善英知
    • Organizer
      JDDW 2016
    • Place of Presentation
      神戸国際会議場 神戸
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
  • [Presentation] 炎症性腸疾患の新しい病態解明から臨床糖鎖免疫学の創成2016

    • Author(s)
      鎌田佳宏、三善英知
    • Organizer
      第35回日本糖質学会年会
    • Place of Presentation
      高知市文化プラザかるぽーと 高知
    • Year and Date
      2016-09-01
    • Related Report
      2016 Research-status Report
  • [Presentation] 血液糖鎖バイオマーカーを使ったBallooning hepatocyteの診断予測2016

    • Author(s)
      鎌田佳宏、竹原徹郎、三善英知
    • Organizer
      第52回日本肝臓学会総会
    • Place of Presentation
      ホテルニューオータニ幕張 千葉
    • Year and Date
      2016-05-19
    • Related Report
      2016 Research-status Report
  • [Presentation] レクチンを用いた新規NASH治療法開発への基礎的検討2016

    • Author(s)
      鎌田佳宏、竹原徹郎、三善英知
    • Organizer
      第102回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル 東京
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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