| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The liver is the central organ of maintenance of the metabolism of the living body, and a method of reconstituting the mini-liver from human pluripotent stem cells in vitro has been developed. On the other hand, it has a disadvantage that it does not have a structure of the functional bile duct network which is important for the function of the liver.
In this study, we are developing a culture system that can be applied to the analysis and treatment of human bile duct disease, by constructing a system that induces bile duct like structures from human iPS cell-derived hepatic progenitor cell. We also analyzed about the efficient culture system of mini-liver tissue using fluid devices.
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