Explorative studies on physiological mechanism of molecular hydrogen
| Project/Area Number |
16K15450
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Chubu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
近藤 孝晴 中部大学, 健康増進センター, 特任教授 (20135388)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 水素分子 / 溶存水素 / 活性酸素 / 心不全 / 呼気水素 / 酸化ストレス / 水素抱合物質 / 抗酸化能 / 病態生理 |
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| Outline of Final Research Achievements |
It is reported that molecular hydrogen improves oxidative stress-induced disease models by inactivation of hydroxical radicals. Human body possesses hydrogen-producing process via colonic fermentation. We found that a part of exogenous hydrogen molecules such as ingestion of hydrogen-rich water and inhaled hydrogen was consumed in the human bodies and in the rat liver. Furthermore, breath hydrogen was significantly decreased, depending upon ages and in patients with higher severity of congestive heart failure.
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| Academic Significance and Societal Importance of the Research Achievements |
水素分子は生体内では未消化の食物繊維などが腸内細菌により生成され，呼気やオナラにより排気される．体内の水素分子がどのような仕組みで体の外にでてくるのか，健康とどのような関連があるのかを人や動物で調べた．その結果，大部分の水素は血流に乗って肺に到達した後，呼気として排気されるが，一部は活性酸素を消去したり，不明のメカニズムにより体の成分に取り込まれたりする可能性があること，また，心不全の重い人ほど睡眠中に呼気中の水素が減る傾向にあることも分かった．
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Report
(5 results)
Research Products
(24 results)
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[Journal Article] Decrease in exhaled hydrogen as marker of congestive heart failure2018
Author(s)
Shibata Atsushi、Sugano Yasuo、Shimouchi Akito、Yokokawa Tetsuro、Jinno Naoya、Kanzaki Hideaki、Ohta-Ogo Keiko、Ikeda Yoshihiko、Okada Hideshi、Aiba Takeshi、Kusano Kengo、Shirai Mikiyasu、Ishibashi-Ueda Hatsue、Yasuda Satoshi、Ogawa Hisao、Anzai Toshihisa
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Journal Title
Open Heart
Volume: 5
Issue: 2
Pages: e000814-e000814
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus2017
Author(s)
Yokokawa T, Sato T, Suzuki S, Oikawa M, Yoshihisa A, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Ishida T, Shimouchi A, Takeishi Y
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Journal Title
BMC Cardiovasc Disord
Volume: 17
Issue: 1
Pages: 280-280
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Change of Exhaled Acetone Concentration in a Diabetic Patient with Acute Decompensated Heart Failure2017
Author(s)
Yokokawa T, Ichijo Y, Houtsuki Y, Matsumoto Y, Oikawa M, Yoshihisa A, Sugimoto K, Nakazato K, Suzuki H, Saitoh S, Shimouchi A, Takeishi Y
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Journal Title
International Heart Journal
Volume: 58
Issue: 5
Pages: 828-830
DOI
NAID
ISSN
1349-2365, 1349-3299
Related Report
Peer Reviewed / Open Access
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[Journal Article] Exhaled Acetone Concentration Is Related to Hemodynamic Severity in Patients With Non-Ischemic Chronic Heart Failure2016
Author(s)
Yokokawa T, Sugano Y, Shimouchi A, Shibata A, Jinno N, Nagai T, Kanzaki H, Aiba T, Kusano K, Shirai M, Takeishi Y, Yasuda S, Ogawa H, Anzai T
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Journal Title
Circ J
Volume: 80(5)
Pages: 1178-86
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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