Role of epigenomic changes and reactive sulfur species in the pathogenesis of chronic obstructive pulmonary disease

• Project/Area Number: 16K15453
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Tohoku University
• Principal Investigator: Sugiura Hisatoshi 東北大学, 医学系研究科, 准教授 (20445092)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: エピゲノム変化 / 活性硫黄分子種 / エピゲノム / COPD / ニトロ化ストレス / 活性窒素種 / レドックス / 酸化ストレス

Outline of Final Research Achievements

In the current project, we aimed to investigate the effects of epigenomic changes in lung resident cells of patients with chronic obstructive pulmonary disease (COPD). We found that the expression of CD169 in the COPD alveolar macrophages, which is involved in phagocytosis of bacteria was significantly attenuated compared to that in the control subjects. Moreover, histone in the bronchial epithelial cells from COPD patients was more nitrated compared to that from healthy subjects. In the COPD lung cells such as bronchial epithelial cells and lung fibroblasts, intracellular levels of reactive sulfur species (RSS) were significantly decreased compared to the lung cells from healthy subjects. Now, we have been studying the role of RSS producing enzyme.

Academic Significance and Societal Importance of the Research Achievements

COPDにおけるエピゲノム変化が病態に及ぼす影響についてはヒストン蛋白のアセチル化の制御については解明されているが、それ以外の変化、とりわけニトロ化については全く不明である。さらに今回、明らかにした細菌貪食受容体の発現低下についてはCOPDの自然歴において重要な増悪病態と深く関連する可能性がある。活性硫黄分子種は全く新規の内因性抗酸化分子でありヒト肺に存在し、COPD患者肺においてその産生量が低下していることは世界初の知見である。本研究成果は呼吸器領域のトップジャーナルであるThorax誌に掲載された。

Research Products

• [Journal Article] Pulmonary Lymphatic Perfusion Syndrome (2019)
  • Author(s): Hirano Taizou、Fujino Naoya、Takase Kei、Ota Hideki、Tanaka Rie、Saito Ryota、Suzuki Ayumi、Okutomo Koji、Sato Teruyuki、Kageyama Sakiko、Tamada Tsutomu、Sugiura Hisatoshi、Ichinose Masakazu
  • Journal Title: American Journal of Respiratory and Critical Care Medicine Volume: 199 Issue: 4 Pages: 529-530
  • DOI: 10.1164/rccm.201806-1125im
  • Peer Reviewed / Open Access
• [Journal Article] Peripheral alveolar nitric oxide concentration reflects alveolar inflammation in autoimmune pulmonary alveolar proteinosis. (2018)
  • Author(s): Hirano T, Ohkouchi S, Tode N, Kobayashi M, Ono M, Satoh T, Mitsuishi Y, Watanabe A, Tabata M, Irokawa T, Ogawa H, Sugiura H, Kikuchi T, Akasaka K, Tazawa R, Inoue Y, Nakata K, Kurosawa H, Ichinose M.
  • Journal Title: ERJ open research Volume: 4 Issue: 1 Pages: 00071-2017
  • DOI: 10.1183/23120541.00071-2017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Correction to: Oxidative stress enhances the expression of IL-33 in human airway epithelial cells (2018)
  • Author(s): Aizawa Hiroyuki、Koarai Akira、Shishikura Yutaka、Yanagisawa Satoru、Yamaya Mutsuo、Sugiura Hisatoshi、Numakura Tadahisa、Yamada Mitsuhiro、Ichikawa Tomohiro、Fujino Naoya、Noda Masafumi、Okada Yoshinori、Ichinose Masakazu
  • Journal Title: Respiratory Research Volume: 19 Issue: 1 Pages: 52-52
  • DOI: 10.1186/s12931-018-0817-9
  • Peer Reviewed / Open Access
• [Journal Article] Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease (2018)
  • Author(s): Rie Tanaka, Hisatoshi Sugiura, Mitsuhiro Yamada, Tomohiro Ichikawa, Akira Koarai, Naoya Fujino, Satoru Yanagisawa, Katsuhiro Onodera, Tadahisa Numakura, Kei Sato, Yorihiko Kyogoku, Hirohito Sano, Shun Yamanaka, Tatsuma Okazaki, Tsutomu Tamada, Motohiko Miura, Tsuneyuki Takahashi, Masakazu Ichinose
  • Journal Title: Int J Chron Obstruct Pulmon Dis. Volume: 13 Pages: 1333-1342
  • DOI: 10.2147/copd.s157035
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The first case of multiple pulmonary granulomas with amyloid deposition in a dental technician; a rare manifestation as an occupational lung disease (2018)
  • Author(s): Hirano Taizou、Numakura Tadahisa、Moriyama Hiroshi、Saito Ryoko、Shishikura Yutaka、Shiihara Jun、Sugiura Hisatoshi、Ichinose Masakazu
  • Journal Title: BMC Pulmonary Medicine Volume: 18 Issue: 1 Pages: 1-5
  • DOI: 10.1186/s12890-018-0654-0
  • Peer Reviewed / Open Access
• [Journal Article] Aspiration pneumonia induces muscle atrophy in the respiratory, skeletal, and swallowing systems. (2018)
  • Author(s): Riyo Komatsu, Tatsuma Okazaki, Satoru Ebihara, Makoto Kobayashi, Yoko Tsukita, Mayumi Nihei, Hisatoshi Sugiura, Kaijun Niu, Takae Ebihara, Masakazu Ichinose.
  • Journal Title: Journal of Cachexia, Sarcopenia and Muscle. Volume: 9(4) Issue: 4 Pages: 643653-643653
  • DOI: 10.1002/jcsm.12297
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expression of cytochrome P450 mRNAs in Type II alveolar cells from subjects with chronic obstructive pulmonary disease (2018)
  • Author(s): Kamata Satoshi、Fujino Naoya、Yamada Mitsuhiro、Grime Ken、Suzuki Satoshi、Ota Chiharu、Tando Yukiko、Okada Yoshinori、Sakurada Akira、Noda Masafumi、Matsuda Yasushi、Sugiura Hisatoshi、Ichinose Masakazu
  • Journal Title: Pharmacology Research & Perspectives Volume: 6 Issue: 3
  • DOI: 10.1002/prp2.405
  • Peer Reviewed / Open Access
• [Journal Article] TLR7 agonist attenuates acetylcholine-induced, Ca2+ -dependent ionic currents in swine tracheal submucosal gland cells (2018)
  • Author(s): Gamo S, Tamada T, Murakami K, Muramatsu S, Aritake H, Nara M, Kazama I, Okazaki T, Sugiura H, Ichinose M
  • Journal Title: Exp Physiol Volume: 103 Issue: 11 Pages: 1543-1559
  • DOI: 10.1113/ep087221
  • Peer Reviewed / Open Access
• [Journal Article] Coexisting COPD in elderly asthma with fixed airflow limitation: assessment by DLco %predicted and HRCT. (2017)
  • Author(s): Tamada T, Sugiura H, Takahashi T, Matsunaga K, Kimura K, Katsumata U, Ohta K, Ichinose M.
  • Journal Title: J Asthma Volume: 印刷中 Issue: 6 Pages: 1-9
  • DOI: 10.1080/02770903.2016.1247168
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Exome sequencing deciphers a germline MET mutation in familial epidermal growth factor receptor-mutant lung cancer. (2017)
  • Author(s): Tode N, Kikuchi T, Sakakibara T, Hirano T, Inoue A, Ohkouchi S, Tamada T, Okazaki T, Koarai A, Sugiura H, Niihori T, Aoki Y, Nakayama K, Matsumoto K, Matsubara Y, Yamamoto M, Watanabe A, Nukiwa T, Ichinose M.
  • Journal Title: Cancer Sci Volume: 印刷中 Issue: 6 Pages: 1263-1270
  • DOI: 10.1111/cas.13233
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Decrease in an anti-ageing factor, growth differentiation factor 11, in chronic obstructive pulmonary disease. (2017)
  • Author(s): Onodera K, Sugiura H, Yamada M, Koarai A, Fujino N, Yanagisawa S, Tanaka R, Numakura T, Togo S, Sato K, Kyogoku Y, Hashimoto Y, Okazaki T, Tamada T, Kobayashi S, Yanai M, Miura M, Hoshikawa Y, Okada Y, Suzuki S, Ichinose M.
  • Journal Title: Thorax Volume: 2017 Issue: 10 Pages: 893-904
  • DOI: 10.1136/thoraxjnl-2016-209352
  • Peer Reviewed / Open Access
• [Journal Article] Invasive pulmonary mucormycosis: rare presentation with pulmonary eosinophilia. (2017)
  • Author(s): Hirano T, Yamada M, Sato K, Murakami K, Tamai T, Mitsuhashi Y, Tamada T, Sugiura H, Sato N, Saito R, Tominaga J, Watanabe A, Ichinose M.
  • Journal Title: BMC Pulm Med Volume: 17 Issue: 1 Pages: 76-76
  • DOI: 10.1186/s12890-017-0419-1
  • Peer Reviewed / Open Access
• [Journal Article] Production of reactive persulfide species in chronic obstructive pulmonary disease (2017)
  • Author(s): Numakura T, Sugiura H, Akaike T, Ida T, Fujii S, Koarai A, Yamada M, Onodera K, Hashimoto Y, Tanaka R, Sato K, Shishikura Y, Hirano T, Yanagisawa S, Fujino N, Okazaki T, Tamada T, Hoshikawa Y, Okada Y, Ichinose M
  • Journal Title: Thorax Volume: 72 Issue: 12 Pages: 1074-1083
  • DOI: 10.1136/thoraxjnl-2016-209359
  • Peer Reviewed / Open Access
• [Journal Article] Japanese guidelines for adult asthma 2017 (2017)
  • Author(s): Ichinose M, Sugiura H, Nagase H, Yamaguchi M, Inoue H, Sagara H, Tamaoki J, Tohda Y, Munakata M, Yamauchi K, Ohta K; Japanese Society of Allergology.
  • Journal Title: Allergology International Volume: 66 Issue: 2 Pages: 163-189
  • DOI: 10.1016/j.alit.2016.12.005
  • NAID: 130005628173
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] COPDのフェノタイプから見た増悪リスク (2017)
  • Author(s): 杉浦久敏
  • Journal Title: 呼吸器内科 Volume: 31 Pages: 554-561
• [Journal Article] 両下肢麻痺を来した肺真菌症の1例 (2017)
  • Author(s): 佐藤 慶、山田 充啓、平野 泰三、三橋 善哉、岡崎 達馬、玉田 勉、杉浦 久敏、一ノ瀬 正和
  • Journal Title: 日本内科学会雑誌 Volume: 106 Pages: 591-595
  • Peer Reviewed
• [Journal Article] COPDの吸入治療 (2017)
  • Author(s): 杉浦久敏
  • Journal Title: 医学のあゆみ Volume: 261 Pages: 213-218
• [Journal Article] 酸化ストレスと気道炎症 (2017)
  • Author(s): 杉浦久敏
  • Journal Title: アレルギー・免疫 Volume: 24 Pages: 450-458
• [Journal Article] 閉塞性肺疾患における気道炎症とバイオマーカー (2017)
  • Author(s): 杉浦久敏
  • Journal Title: 別冊バイオクリニカ:慢性炎症と疾患 Volume: 6 Pages: 22-26
• [Journal Article] 酸化ストレスと喘息の重症化 (2017)
  • Author(s): 杉浦久敏、一ノ瀬正和
  • Journal Title: アレルギー Volume: 66 Pages: 931-935
  • NAID: 130005975420
• [Journal Article] 好酸球性肺炎の像を呈した肺接合菌症の1例 (2017)
  • Author(s): 平野 泰三、山田 充啓、村上 康司、佐藤 慶、 玉井 ときわ、 高橋 秀徳、岡崎 達馬、玉田 勉、杉浦 久敏、一ノ瀬 正和
  • Journal Title: 日本内科学会雑誌 Volume: 106 Pages: 1006-1011
  • NAID: 130006733547
  • Peer Reviewed
• [Journal Article] 呼吸器疾患と慢性炎症 閉塞性肺疾患における気道炎症とバイオマーカー (2017)
  • Author(s): 杉浦久敏
  • Journal Title: 別冊BIO Clinica 炎症と疾患 Volume: 6 Pages: 22-26
• [Journal Article] Possible role of Krüppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease. (2016)
  • Author(s): Abe. K., H. Sugiura, Y. Hashimoto, T. Ichikawa, A. Koarai, M. Yamada, T. Numakura, K. Onodera, R. Tanaka, K. Sato, S. Yanagisawa, T. Okazaki, T. Tamada, T. Kikuchi and M. Ichinose.
  • Journal Title: Respir Res Volume: 17 Issue: 1 Pages: 7-7
  • DOI: 10.1186/s12931-016-0322-y
  • Peer Reviewed / Open Access
• [Journal Article] 27-hydroxycholesterol accelerates cellular senescence in human lung resident cells. (2016)
  • Author(s): Hashimoto Y, Sugiura H, Togo S, Koarai A, Abe K, Yamada M, Ichikawa T, Kikuchi T, Numakura T, Onodera K, Tanaka R, Sato K, Yanagisawa S, Okazaki T, Tamada T, Kikuchi T, Hoshikawa Y, Okada Y, Ichinose M.
  • Journal Title: Am J Physiol Lung Cell Mol Physiol Volume: 310 Issue: 11 Pages: L1028-L1041
  • DOI: 10.1152/ajplung.00351.2015
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis. (2016)
  • Author(s): Makiguchi T, Yamada M, Yoshioka Y, Sugiura H, Koarai A, Chiba S, Fujino N, Tojo Y, Ota C, Kubo H, Kobayashi S, Yanai M, Shimura S, Ochiya T, Ichinose M.
  • Journal Title: Respir Res Volume: 17 Issue: 1 Pages: 110-110
  • DOI: 10.1186/s12931-016-0427-3
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Extracellular ATP is involved in dsRNA-induced MUC5AC production via P2Y2R in human airway epithelium. (2016)
  • Author(s): Shishikura Y, Koarai A, Aizawa H, Yamaya M, Sugiura H, Watanabe M, Hashimoto Y, Numakura T, Makiguti T, Abe K, Yamada M, Kikuchi T, Hoshikawa Y, Okada Y, Ichinose M.
  • Journal Title: Respir Res Volume: 17
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Two cases of pseudo-achalasia with lung cancer: Case report and short literature review. (2016)
  • Author(s): Hirano T, Miyauchi E, Inoue A, Igusa R, Chiba S, Sakamoto K, Sugiura H, Kikuchi T, Ichinose M.
  • Journal Title: Respir Invest Volume: 54 Issue: 6 Pages: 494-499
  • DOI: 10.1016/j.resinv.2016.04.006
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] COPDと免疫異常 (2016)
  • Author(s): 杉浦久敏
  • Journal Title: 炎症と免疫 Volume: 24 Pages: 325-330
• [Journal Article] 発熱、多関節痛を伴った急性サルコイドーシスの1例 (2016)
  • Author(s): 小野寺克洋、玉田勉、村松聡士、村上康司、奈良正之、小松理世、小林誠、山田充啓、杉浦久敏、一ノ瀬正和
  • Journal Title: 日本内科学会雑誌 Volume: 105 Pages: 540-546
  • NAID: 130005439474
• [Journal Article] 日常臨床から学ぶ この症例の新しい意義は? 好酸球性肺炎の像を呈し全身播種に至った肺接合菌症の1例 (2016)
  • Author(s): 山田充啓、平野泰三、佐藤慶、高橋秀徳、村上康司、玉井ときわ、玉田勉、杉浦久敏、佐藤直実、齋藤涼子、一ノ瀬正和
  • Journal Title: THE LUNG-perspectives Volume: 24 Pages: 338-345
• [Journal Article] ARDSを合併したChlamydophila pneumoniae感染症の1例 (2016)
  • Author(s): 突田容子、山田充啓、大江崇、伊藤俊輔、小林誠、玉井ときわ、小荒井晃、玉田勉, 杉浦久敏、一ノ瀬正和
  • Journal Title: 日本内科学会雑誌 Volume: 105 Pages: 2426-2431
  • NAID: 130006248766
• [Presentation] 喘息とCOPDのオーバーラップ（ACO）における活性イオウ分子種と活性イオウ分子種産生酵素に関する検討 (2019)
  • Author(s): .京極自彦、杉浦久敏、市川朋宏、沼倉忠久、小荒井晃、山田充啓、藤野直也、田中里江、佐野寛仁、山中 駿、一ノ瀬正和
  • Organizer: 第108回日本呼吸器学会東北地方会
• [Presentation] Gaシンチグラフィーでnegative heart sign を認めた急性発症肺サルコイドーシスの1例 (2019)
  • Author(s): 鈴木 歩、平野泰三、玉田 勉、田中里江、藤野直也、齋藤良太、村上康司、杉浦久敏、一ノ瀬正和
  • Organizer: 第216回日本内科学会東北地方会
• [Presentation] 好酸球増多を伴う重症喘息に対してmepolizumabが奏効した一例 (2019)
  • Author(s): 大江 崇、奥友洸二、山田充啓、東出直樹、村上康司、藤野直也、小荒井晃、玉田 勉、杉浦久敏、一ノ瀬正和
  • Organizer: 第1回日本アレルギー学会東北地方会
• [Presentation] 喘息合併COPD: 病態と治療 ACOのガイドラインにおける診断基準と治療 (2018)
  • Author(s): 杉浦 久敏
  • Organizer: 第67回日本アレルギー学会学術大会
  • Invited
• [Presentation] Update on FeNO (2018)
  • Author(s): Hisatoshi Sugiura
  • Organizer: APSR 2018 in Taipei
  • Int'l Joint Research / Invited
• [Presentation] Production of Reactive Persulfide Species and Their Effects in the Lungs of Patients with COPD. (2018)
  • Author(s): Numakura T, Sugiura H, Akaike T, Yamada M, Ichikawa T, Yanagisawa S, Koarai A, Ichinose M.
  • Organizer: 2018 ATS International Conference
  • Int'l Joint Research
• [Presentation] Circulating ACE+ EMPs are a potential marker for evaluating pulmonary endothelial injury during ARDS (2018)
  • Author(s): Takei Y, Yamada M, Saito K, Kameyama Y, Sugiura H, Makiguchi T, Fujino N, Toyama H, Saito K, Ejima Y, Kawazoe Y, Kudo D, Kushimoto S, Yamauchi M, Ichinose M
  • Organizer: 2018 ATS International Conference
  • Int'l Joint Research
• [Presentation] Oxidative Stress Enhances the Expression of IL-33 in Airway Epithelial Cells During Virus Infection. (2018)
  • Author(s): Aizawa H, Koarai A, Shishikura Y, Yanagisawa S, Yamaya M, Sugiura H, Numakura T, Yamada M, Ichikawa T, Fujino N, Noda M, Okada Y, Ichinose M
  • Organizer: 2018 ATS International Conference
  • Int'l Joint Research
• [Presentation] Enhanced Nitrosative Stress in the Airways of Patients with Asthma-Chronic Obstructive Pulmonary Disease Overlap. (2018)
  • Author(s): Kyogoku Y, Sugiura H, Numakura T, Ichikawa T, Yamada M, Koarai A, Tanaka R, Ito S, Akaike T, Ichinose M.
  • Organizer: 2018 ATS International Conference
  • Int'l Joint Research
• [Presentation] Production of reactive persulfide species in lungs of patients with COPD and their effects on lung resident cells. (2018)
  • Author(s): Numakura T, Sugiura H, Akaike T, Yamada M, Ichikawa T, Fujino N, Koarai A, Ichinose M
  • Organizer: 23rd Congress of the Asian Pacific Society of Respiratory
  • Int'l Joint Research
• [Presentation] Production of reactive nitrogen species in asthma-chronic obstructive pulmonary disease overlap. (2018)
  • Author(s): Kyogoku Y, Sugiura H, Numakura T, Ichikawa T, Yamada M, Koarai A, Tanaka R, Akaike T,
  • Organizer: 23rd Congress of the Asian Pacific Society of Respiratory
  • Int'l Joint Research
• [Presentation] COPD合併喘息（ACO）における活性窒素種と活性硫黄種に関する検討 (2018)
  • Author(s): 京極自彦、杉浦久敏、沼倉忠久、市川朋宏、山田充啓、一ノ瀬正和
  • Organizer: 第58回日本呼吸器学会学術講演会
• [Presentation] ヒト気道上皮IL-33発現に対する酸化ストレスの影響 (2018)
  • Author(s): 相澤洋之、小荒井晃、宍倉 裕、柳澤 悟、山谷睦雄、杉浦久敏、沼倉忠久、山田充啓、市川朋宏、藤野直也、一ノ瀬正和
  • Organizer: 第58回日本呼吸器学会学術講演会
• [Presentation] 東北メディカルメガバンク地域住民コホート調査に基づく、日本人呼気一酸化窒素濃度の分布と影響因子の解析（中間報告） (2018)
  • Author(s): 山田充啓、杉浦久敏、布施昇男、寳澤 篤、高井貴子、土屋奈歩、光根 歩、栗山進一、山本雅之、一ノ瀬正和
  • Organizer: 第58回日本呼吸器学会学術講演会
• [Presentation] COPDに対する気管支拡張薬が気道被覆液の質的特性に及ぼす影響の検討 (2018)
  • Author(s): 有竹秀美、玉田 勉、村上康司、蒲生俊一、村松聡士、奈良正之、杉浦久敏、一ノ瀬正和
  • Organizer: 第58回日本呼吸器学会学術講演会
• [Presentation] TLR7刺激による Sarco/Endoplasimic Reticulm Caicium ATPase（SERCA）作用更新についての検討 (2018)
  • Author(s): 蒲生俊一、玉田 勉、村上康司、有竹秀美、村松聡士、奈良正之、杉浦久敏、一ノ瀬正和
  • Organizer: 第58回日本呼吸器学会学術講演会
• [Presentation] リンパ管を標的とした新規胸膜炎治療の検討 (2018)
  • Author(s): 小林 誠、岡崎達馬、突田容子、小松理世、杉浦久敏、海老原覚、一ノ瀬正和
  • Organizer: 第58回日本呼吸器学会学術講演会
• [Presentation] EGFR変異遺伝子陽性肺腺癌においてAXLキナーゼは免疫抑制分子を制御する (2018)
  • Author(s): 突田容子、藤野直也、宮内栄作、井上 彰、板倉康司、山田充啓、岡崎達馬、桜田 晃、杉浦久敏、岡田克典、一ノ瀬正和
  • Organizer: 第58回日本呼吸器学会学術講演会
• [Presentation] スケドスポリウム属によるステント腐生により喘息様症状を呈した1例 (2018)
  • Author(s): 大江 崇、小荒井晃、平野泰三、佐藤輝幸、市川朋宏、岡崎達馬、玉田 勉、杉浦久敏、一ノ瀬正和
  • Organizer: 第214回日本内科学会東北地方会
• [Presentation] Stevens-Johnson症候群による閉塞性肺気管支炎が疑われ、気管支鏡検査で水泡状の気道粘膜病変を認めた一例 (2018)
  • Author(s): 成田大輔、山田充啓、佐藤輝幸、市川朋宏、小林 誠、千葉茂樹、滝田克也、小荒井晃、玉田 勉、杉浦久敏、一ノ瀬正和
  • Organizer: 第107回日本呼吸器学会東北地方会/第137回日本結核病学会東北地方会
• [Presentation] 当科における重症喘息患者に対する抗IL-5抗体治療の現状 (2018)
  • Author(s): 奥友洸二、山田充啓、小荒井晃、玉田 勉、杉浦久敏、一ノ瀬正和
  • Organizer: 第215回日本内科学会東北地方会
• [Presentation] Role of oxidative stress in chronic obstructive pulmonary disease. (2017)
  • Author(s): Hisatoshi Sugiura
  • Organizer: KI-ToMMo joint conference
  • Int'l Joint Research
• [Presentation] 新旧ガイドラインの比較 (2017)
  • Author(s): 杉浦久敏
  • Organizer: 第38回日本呼吸器学会春期生涯教育講演会
  • Invited
• [Presentation] 免疫炎症細胞からみた重症呼吸器疾患の病態と治療の展望 COPD (2017)
  • Author(s): 杉浦久敏
  • Organizer: 第57回日本呼吸器学会学術講演会
  • Invited
• [Presentation] COPDに潜む喘息 (2017)
  • Author(s): 杉浦久敏
  • Organizer: 第57回日本呼吸器学会学術講演会
  • Invited
• [Presentation] COPDの増悪overview 増悪を来しやすいフェノタイプ (2017)
  • Author(s): 杉浦久敏
  • Organizer: 第45回吸入療法研究会
  • Invited
• [Presentation] 新旧ガイドラインの比較 (2017)
  • Author(s): 杉浦久敏
  • Organizer: 第38回日本呼吸器学会秋期生涯教育講演会
  • Invited
• [Presentation] 気管支喘息におけるFeNO測定の意義 (2017)
  • Author(s): 杉浦久敏
  • Organizer: 第27回日本呼吸ケア・リハビリテーション学会学術集会
  • Invited
• [Presentation] 尿中抗原陰性で喀痰PCR検査により診断されたレジオネラ肺炎の1例 (2017)
  • Author(s): 佐野寛仁、山田充啓、平野泰三、村上康司、椎原 淳、宇佐美修、玉田 勉、杉浦久敏、舘田一博、一ノ瀬正和
  • Organizer: 第210回日本内科学会東北地方会
• [Presentation] mycobacterium shinjukuense 肺感染症の1例 (2017)
  • Author(s): 山田充啓、玉井ときわ、鹿住祐子、突田容子、玉田 勉、杉浦久敏、一ノ瀬正和
  • Organizer: 第104回日本呼吸器学会東北地方会/第134回日本結核病学会東北支部学会
• [Presentation] 腫瘍崩壊症候群を自然発症した肺扁平上皮癌の1例 (2017)
  • Author(s): 板倉康司、平野泰三、宮内栄作、井上 彰、小林 誠、玉井ときわ、岡崎達馬、玉田 勉、杉浦久敏、一ノ瀬正和
  • Organizer: 第104回日本呼吸器学会東北地方会/第134回日本結核病学会東北支部学会
• [Presentation] COPDにおける老化抑制因子Growth differentiation factor11(GDF11)の関与に関する研究 (2017)
  • Author(s): 小野寺克洋、杉浦久敏、山田充啓、田中里江、一ノ瀬正和
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] 誤嚥性肺炎はマイオカインを誘導し筋肉を委縮させる (2017)
  • Author(s): 小松理世、岡崎達馬、突田容子、小林 誠、二瓶真由美、杉浦久敏、海老原覚、一ノ瀬正和
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] 客観的指標を用いたCOPD合併喘息の検討 (2017)
  • Author(s): 玉田 勉、杉浦久敏、高橋識至、松永和人、勝又宇一郎、木村啓二、大田 健、一ノ瀬正和
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] COPD患者における活性イオウ分子種（reactive sulfur species:RSS）の産生に関する検討 (2017)
  • Author(s): 沼倉忠久、杉浦久敏、赤池孝章、一ノ瀬正和
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] ライノウイルス感染による粘液産生誘導に対する細胞外ATPの関与の検討 (2017)
  • Author(s): 相澤洋之、小荒井晃、宍倉 裕、山谷睦雄、杉浦久敏、沼倉忠久、山田充啓、一ノ瀬正和
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] Axl Receptor Tyrosine Kinase Regulates Dying Cell-Triggered Proliferation of Airway Basal Cells and Is Involved Epithelial Remodeling of COPD. (2017)
  • Author(s): 178.Naoya Fujino, Toshihumi Fujimori, Aleksander M. Grabiec, Rose A.Maciewicz, Katsuhiro Onodera, Tadahisa Numakura, Mitsuhiro Yamada, Hisatoshi Sugiura, Tracy Hussell, Masakazu Ichinose
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] TLR7リガンドによる気道分泌制御作用の細胞内機序について (2017)
  • Author(s): 蒲生俊一、玉田 勉、村松聡士、村上康司、奈良正之、杉浦久敏、一ノ瀬正和
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] ライノウイルス感染によるムチン産生に対する細胞外ATPの関与の検討 (2017)
  • Author(s): 相澤洋之、小荒井晃、宍倉 裕、山谷睦雄、杉浦久敏、沼倉忠久、山田充啓、一ノ瀬正和
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] セリチニブ投与に関連した肝内胆管拡張に伴う遷延性薬剤性胆汁うっ滞を発症した肺癌の1例 (2017)
  • Author(s): 山田充啓、平野泰三、佐野寛仁、村上康司、岡崎達馬、玉田 勉、杉浦久敏、藤井博司、一ノ瀬正和
  • Organizer: 第212回日本内科学会東北地方会
• [Presentation] 可逆性の肺高血圧症を呈した強皮症によるShrinking lung syndromeの一例 (2017)
  • Author(s): 山中 駿、東條 裕、佐々木優作、千葉茂樹、宮内栄作、玉井ときわ、玉田 勉、杉浦久敏、小川浩正、一ノ瀬正和
  • Organizer: 第105回日本呼吸器学会東北地方会/第135回日本結核病学会東北地方会
• [Presentation] Decreased Levels of Plasma Growth Differentiation Factor 11 Are Associated with Physical Activity, Exercise Capacity and Systemic Inflammation in COPD. (2017)
  • Author(s): Tanaka R, Sugiura H, Yamada M, Onodera K, Numakura T, Miura M, Takahashi T, Ichinose M
  • Organizer: 2017 ATS International Conference
  • Int'l Joint Research
• [Presentation] Gene Expression Profiles in Isolated Lung Endothelial Cells in Chronic Obstructive Pulmonary Disease. (2017)
  • Author(s): Tojo Y, Yamada M, Fujino N, Chiba S, Shibuya R, Koarai A, Sugiura H, Ogawa H, Ichinose M.
  • Organizer: 2017 ATS International Conference
  • Int'l Joint Research
• [Presentation] Upregulation of Ca2+-ATPase by TLR7 decreases electrolyte secretion from airway submucosal gland cells. (2017)
  • Author(s): Gamo S, Tamada T, Muramatsu S, Murakami K, Nara M, Sugiura H, IchinoseM
  • Organizer: 2017 ATS International Conference
  • Int'l Joint Research
• [Presentation] Involvement of Extracellular ATP in Mucus Production During Rhinovirus Infection. (2017)
  • Author(s): Aizawa H, Koarai A, Shishikura Y, Yamaya M, Sugiura H, Watanabe M, Hashimoto Y, Numakura T, Makiguchi T, Abe K, Yamada M, Kikuchi T, Hoshikawa Y, Okada Y, Ichinose M.
  • Organizer: 2017 ATS International Conference
  • Int'l Joint Research
• [Presentation] Oxidattive stress and COPD. (2016)
  • Author(s): H. Sugiura
  • Organizer: 2016. 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Sendai(Sendai International Center)
  • Int'l Joint Research / Invited
• [Presentation] Role of oxidative stress in the pathogenesis of COPD (2016)
  • Author(s): 杉浦久敏
  • Organizer: 箱根呼吸討論会
  • Place of Presentation: 東京都(グランドニッコウ東京台場）
  • Invited
• [Presentation] 呼吸器領域における呼気一酸化窒素(NO)測定の意義－原理と実際 (2016)
  • Author(s): 杉浦久敏
  • Organizer: 日本酸化ストレス学会
  • Place of Presentation: 宮城県仙台市（仙台国際センター）
  • Invited
• [Book] 呼吸器疾患 最新の薬物療法 (2017)
  • Author(s): 山田充啓、杉浦久敏
  • Total Pages: 256
  • Publisher: 克誠堂出版