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Comprehensive analysis of druggable tyrosine kinase in idiopathic interstitial pneumonia

Research Project

Project/Area Number 16K15458
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Research InstitutionOkayama University

Principal Investigator

Kiura Katsuyuiki  岡山大学, 大学病院, 教授 (10243502)

Co-Investigator(Kenkyū-buntansha) 大橋 圭明  岡山大学, 大学病院, 講師 (60729193)
久保 寿夫  岡山大学, 大学病院, 助教 (90726928)
Research Collaborator HIGO Hisao  岡山大学, 大学院医師薬学総合研究科, 大学院生
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords肺線維症 / 特発性肺線維症 / 次世代シーケンサー / Kinase遺伝子発現解析 / レーザーマイクロダイセクション / 臨床呼吸器学
Outline of Final Research Achievements

We performed comprehensive analysis in plumonary fibrosis to develop precision medicine. We obtained 13 samples from 5 patients. 6 samples were from bilateral pneumotectomy. The gene expression profile was heterogeneous even in same patient. ERBB4 or PIM2 was overexpressed in some of our cases. These genes might be possible druggable target for pulmonary fibrosis.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (24 results)

All 2018 2017 2016

All Journal Article (19 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 19 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Second primary cancer in survivors of locally advanced non-small cell lung cancer treated with concurrent chemoradiation followed by surgery2018

    • Author(s)
      Makimoto Go、Kubo Toshio、Oze Isao、Ohashi Kadoaki、Hotta Katsuyuki、Tabata Masahiro、Soh Junichi、Toyooka Shinichi、Katsui Kuniaki、Takigawa Nagio、Tanimoto Mitsune、Kiura Katsuyuki
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 48 Issue: 3 Pages: 287-290

    • DOI

      10.1093/jjco/hyy003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MET or NRAS amplification is an acquired resistance mechanism to the third-generation EGFR inhibitor naquotinib2018

    • Author(s)
      Ninomiya Kiichiro、Ohashi Kadoaki、Makimoto Go、Tomida Shuta、Higo Hisao、Kayatani Hiroe、Ninomiya Takashi、Kubo Toshio、Ichihara Eiki、Hotta Katsuyuki、Tabata Masahiro、Maeda Yoshinobu、Kiura Katsuyuki
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 1955-1955

    • DOI

      10.1038/s41598-018-20326-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phase 3 study of ceritinib vs chemotherapy in ALK-rearranged NSCLC patients previously treated with chemotherapy and crizotinib (ASCEND-5): Japanese subset2018

    • Author(s)
      Kiura Katsuyuki、Imamura Fumio、Kagamu Hiroshi、Matsumoto Shingo、Hida Toyoaki、Nakagawa Kazuhiko、Satouchi Miyako、Okamoto Isamu、Takenoyama Mitsuhiro、Fujisaka Yasuhito、Kurata Takayasu、Ito Masayuki、Tokushige Kota、Hatano Ben、Nishio Makoto
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 48 Issue: 4 Pages: 367-375

    • DOI

      10.1093/jjco/hyy016

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osimertinib in patients with epidermal growth factor receptor T790M advanced non-small cell lung cancer selected using cytology samples2018

    • Author(s)
      Kiura Katsuyuki、Yoh Kiyotaka、Katakami Nobuyuki、Nogami Naoyuki、Kasahara Kazuo、Takahashi Toshiaki、Okamoto Isamu、Cantarini Mireille、Hodge Rachel、Uchida Hirohiko
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 4 Pages: 1177-1184

    • DOI

      10.1111/cas.13511

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Randomized, Double-Blind Phase Ib/III Study of Erlotinib With Ramucirumab or Placebo in Previously Untreated EGFR -Mutant Metastatic Non-Small-Cell Lung Cancer (RELAY): Phase Ib Results2018

    • Author(s)
      Reck Martin、Garon Edward B.、Paz-Ares Luis、Ponce Santiago、Jaime Jesus Corral、Juan Oscar、Nadal Ernest、Kiura Katsuyuki、Widau Ryan C.、He Shuang、Dalal Rita、Lee Pablo、Nakagawa Kazuhiko
    • Journal Title

      Clinical Lung Cancer

      Volume: 19 Issue: 3 Pages: 213-220.e4

    • DOI

      10.1016/j.cllc.2017.11.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Phase II Study of Trastuzumab Emtansine in HER2-Positive Non-Small Cell Lung Cancer2018

    • Author(s)
      Hotta Katsuyuki、Aoe Keisuke、Kozuki Toshiyuki、Ohashi Kadoaki、Ninomiya Kiichiro、Ichihara Eiki、Kubo Toshio、Ninomiya Takashi、Chikamori Kenichi、Harada Daijiro、Nogami Naoyuki、Hirata Taizo、Hinotsu Shiro、Toyooka Shinichi、Kiura Katsuyuki
    • Journal Title

      Journal of Thoracic Oncology

      Volume: 13 Issue: 2 Pages: 273-279

    • DOI

      10.1016/j.jtho.2017.10.032

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase I trial of afatinib and bevacizumab in chemo-naive patients with advanced non-small-cell lung cancer harboring EGFR mutations: Okayama Lung Cancer Study Group Trial 1404.2018

    • Author(s)
      Ninomiya T, Nogami N, Kozuki T, Harada D, Kubo T, Ohashi K, Kuyama S, Kudo K, Bessho A, Fukamatsu N, Fujimoto N, Aoe K, Shibayama T, Sugimoto K, Takigawa N, Hotta K, Kiura K.
    • Journal Title

      Lung Cancer.

      Volume: 115 Pages: 103-108

    • DOI

      10.1016/j.lungcan.2017.11.025

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential influence of interleukin-6 on the therapeutic effect of gefitinib in patients with advanced non-small cell lung cancer harbouring EGFR mutations.2018

    • Author(s)
      Tamura T, Kato Y, Ohashi K, Ninomiya K, Makimoto G, Gotoda H, Kubo T, Ichihara E, Tanaka T, Ichimura K, Maeda Y, Hotta K, Kiura K.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 495 Issue: 1 Pages: 360-367

    • DOI

      10.1016/j.bbrc.2017.10.175

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase II trial of carboplatin plus S-1 for elderly patients with advanced non-small-cell lung cancer with wild-type epidermal growth factor receptor: The Okayama Lung Cancer Study Group Trial 12022017

    • Author(s)
      Kuyama Shoichi、Ochi Nobuaki、Bessho Akihiro、Hotta Katsuyuki、Ikeda Genyo、Kishino Daizo、Kubo Toshio、Harada Daijiro、Fujimoto Nobukazu、Nakanishi Masamoto、Umeno Takahiro、Okada Toshiaki、Chikamori Kenichi、Yamagishi Tomoko、Ohashi Kadoaki、Ichihara Eiki、Takigawa Nagio、Tanimoto Mitsune、Kiura Katsuyuki
    • Journal Title

      Lung Cancer

      Volume: 112 Pages: 188-194

    • DOI

      10.1016/j.lungcan.2017.08.010

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics of Japanese candidates for lung transplant for interstitial lung disease and risk factors for early death while on the waiting list2017

    • Author(s)
      Higo Hisao、Kurosaki Takeshi、Ichihara Eiki、Kubo Toshio、Miyoshi Kentaroh、Otani Shinji、Sugimoto Seiichiro、Yamane Masaomi、Miyahara Nobuaki、Kiura Katsuyuki、Miyoshi Shinichiro、Oto Takahiro
    • Journal Title

      Respiratory Investigation

      Volume: 55 Issue: 4 Pages: 264-269

    • DOI

      10.1016/j.resinv.2017.03.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ceritinib versus chemotherapy in patients with ALK -rearranged non-small-cell lung cancer previously given chemotherapy and crizotinib (ASCEND-5): a randomised, controlled, open-label, phase 3 trial2017

    • Author(s)
      Shaw Alice T、Kim Tae Min、Crino Lucio、Gridelli Cesare、Kiura Katsuyuki、Liu Geoffrey、Novello Silvia、Bearz Alessandra、Gautschi Oliver、Mok Tony、Nishio Makoto、Scagliotti Giorgio、Spigel David R、Deudon Stephanie、Zheng Cheng、Pantano Serafino、Urban Patrick、Massacesi Cristian、et al.
    • Journal Title

      The Lancet Oncology

      Volume: 18 Issue: 7 Pages: 874-886

    • DOI

      10.1016/s1470-2045(17)30339-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Triplet therapy with afatinib, cetuximab, and bevacizumab induces deep remission in lung cancer cells harboring EGFR T790M in vivo.2017

    • Author(s)
      Kudo K, Ohashi K, Makimoto G, Higo H, Kato Y, Kayatani H, Kurata Y, Takami Y, Minami D, Ninomiya T, Kubo T, Ichihara E, Sato A, Hotta K, Yoshino T, Tanimoto M, Kiura K.
    • Journal Title

      Mol Oncol

      Volume: Epub Issue: 6 Pages: 670-681

    • DOI

      10.1002/1878-0261.12063

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ceritinib in patients with advanced, crizotinib-treated, anaplastic lymphoma kinase-rearranged NSCLC: Japanese subset2017

    • Author(s)
      Hida Toyoaki、Satouchi Miyako、Nakagawa Kazuhiko、Seto Takashi、Matsumoto Shingo、Kiura Katsuyuki、Nokihara Hiroshi、Murakami Haruyasu、Tokushige Kota、Hatano Ben、Nishio Makoto
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 47 Issue: 7 Pages: 618-624

    • DOI

      10.1093/jjco/hyx045

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-Year Follow-Up of an Alectinib Phase I/II Study in ALK-Positive Non-Small-Cell Lung Cancer: AF-001JP2017

    • Author(s)
      Tamura Tomohide、Kiura Katsuyuki、Seto Takashi、Nakagawa Kazuhiko、Maemondo Makoto、Inoue Akira、Hida Toyoaki、Yoshioka Hiroshige、Harada Masao、Ohe Yuichiro、Nogami Naoyuki、Murakami Haruyasu、Kuriki Hiroshi、Shimada Tadashi、Tanaka Tomohiro、Takeuchi Kengo、Nishio Makoto
    • Journal Title

      Journal of Clinical Oncology

      Volume: 35 Issue: 14 Pages: 1515-1521

    • DOI

      10.1200/jco.2016.70.5749

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endobronchial ultrasound-guided transbronchial needle aspiration of hilar and mediastinal lymph nodes detected on 18F-fluorodeoxyglucose positron emission tomography/computed tomography2016

    • Author(s)
      Minami D, Takigawa N, Oda N, Ninomiya T, Kubo T, Ohashi K, Sato A, Hotta K, Tabata M, Kaji M, Tanimoto M, Kiura K..
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 46 Issue: 6 Pages: 529-33

    • DOI

      10.1093/jjco/hyw023

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of a skin rash within the first week and the therapeutic effect in afatinib monotherapy for EGFR-mutant non-small cell lung cancer (NSCLC): Okayama Lung Cancer Study Group experience.2016

    • Author(s)
      Kudo K, Hotta K, Bessho A, Nogami N, Kozuki T, Kuyama S, Inoue K, Harita S, Okada T, Gemba K, Fujii M, Takigawa N, Oda N, Tanimoto M, Kiura K.
    • Journal Title

      Cancer Chemother Pharmacol.

      Volume: 77 Issue: 5 Pages: 1005-9

    • DOI

      10.1007/s00280-015-2910-9

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Safety and discomfort during bronchoscopy performed under sedation with fentanyl and midazolam: a prospective study.2016

    • Author(s)
      Minami D, Takigawa N, Watanabe H, Ninomiya T, Kubo T, Ohashi K, Sato A, Hotta K, Tabata M, Tanimoto M, Kiura K.
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 46 Issue: 9 Pages: 871-4

    • DOI

      10.1093/jjco/hyw083

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] A phase II study of topotecan and cisplatin with sequential thoracic radiotherapy in elderly patients with small-cell lung cancer: Okayama Lung Cancer Study Group 0102.2016

    • Author(s)
      Kubo T, Fujiwara K, Hotta K, Okada T, Kuyama S, Harita S, Ninomiya T, Kamei H, Hosokawa S, Bessho A, Maeda T, Kozuki T, Fujimoto N, Ninomiya K, Takemoto M, Kanazawa S, Takigawa N, Tabata M, Tanimoto M, Ueoka H, Kiura K.
    • Journal Title

      Cancer Chemother Pharmacol.

      Volume: 78 Issue: 4 Pages: 769-74

    • DOI

      10.1007/s00280-016-3135-2

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Potential influence of being overweight on the development of hepatic dysfunction in Japanese patients with EGFR-mutated non-small cell lung cancer undergoing gefitinib monotherapy: the Okayama Lung Cancer Study Group experience.2016

    • Author(s)
      Oda N, Hotta K, Yoshioka H, Kudo K, Ichihara E, Kato Y, Ninomiya K, Minami D, Ninomiya T, Kubo T, Ohashi K, Sato A, Takigawa N, Tabata M, Tanimoto M, Kiura K.
    • Journal Title

      Cancer Chemother Pharmacol.

      Volume: 78 Issue: 5 Pages: 941-47

    • DOI

      10.1007/s00280-016-3146-z

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Acquired resistance to the third-generation EGFR inhibitor ASP8273 is associated with MET or NRAS gene amplifications in preclinical models2017

    • Author(s)
      Kiichiro Ninomiya, Kadoaki Ohashi, Shuta Tomida, Hiroe Kayatani, Tomoki Tamura, Hisao Higo, Go Makimoto, Takashi Ninomiya, Toshio Kubo, Eiki Ichihara, Akiko Sato, Katsuyuki Hotta, Masahiro Tabata, Katsuyuki Kiura.
    • Organizer
      AACR Annual Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A comprehensive analysis of autopsied specimens and patient-derived cell lines in ALK-positive lung cancers with rapid acquired resistance to alectinib2017

    • Author(s)
      Go Makimoto, Kadoaki Ohashi, Kazuya Nishii, Shuta Tomida, Hiroe Kayatani, Tomoki Tamura, Hisao Higo, Kiichiro Ninomiya, Takashi Ninomiya, Toshio Kubo, Eiki Ichihara, Akiko Sato, Katsuyuki Hotta, Masahiro Tabata, Katsuyuki Kiura
    • Organizer
      AACR Annual Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical Characteristics of Japanese Candidates for Lung Transplant Due to Interstitial Lung Disease and Risk Factors for Early Death While on the Waiting List2017

    • Author(s)
      Hisao Higo , Eiki Ichihara , Takeshi Kurosaki , Kentaroh Miyoshi , Toshio Kubo , Shinji Otani , Seiichiro Sugimoto , Masaomi Yamane , Nobuaki Miyahara , Katsuyuki Kiura , Takahiro Oto
    • Organizer
      American Thoracic Society 2017 International Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Second primary cancer in survivors of locally advanced NSCLC treated with concurrent chemoradiation followed by surgery.2016

    • Author(s)
      Go Makimoto, Toshio Kubo, Yuka Kato, Takashi Ninomiya, Isao Oze, Kadoaki Ohashi, Eiki Ichihara, Katsuyuki Hotta, Masahiro Tabata, Nagio Takigawa, Shinichi Toyooka, Kuniaki Katsui, Mitsune Tanimoto, Katsuyuki Kiura
    • Organizer
      2016 ASCO Annual Meeting
    • Place of Presentation
      Chicago
    • Year and Date
      2016-06-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Molecular Profiling of Idiopathic Pulmonary Fibrosis2016

    • Author(s)
      肥後 寿夫、木浦 勝行
    • Organizer
      第2回 呼吸器基礎研究を加速するための若手研究会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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