Establishment of innovative culture system, kidney-on-chip, utilizing microdevice
| Project/Area Number |
16K15464
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
藤井 輝夫 東京大学, 生産技術研究所, 教授 (30251474)
稲城 玲子 東京大学, 医学部附属病院, 特任准教授 (50232509)
田中 哲洋 東京大学, 医学部附属病院, 講師 (90508079)
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| Research Collaborator |
DOI Kotaro 東京大学, 大学院医学系研究科, 大学院生
CHIKAMORI Masatomo 東京大学, 大学院医学系研究科, 大学院生
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | マイクロデバイス / organ on chip / 医工連携 / podocyte / 尿細管 / 慢性腎臓病 / 腎不全 |
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| Outline of Final Research Achievements |
We established an innovative culture system with microdevice, kidney-on-chip, which reproduces physical stress of glomerular filtrates and in vivo conditions. We established polydimethylsiloxane (PDMS)-based compartment microfluidic cocultivation system of podocytes and renal tubular cells on multi-pore membrane coated with extracellular matrix.
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Report
(3 results)
Research Products
(2 results)
