Visualization of small metabolites in the kidney for elucidation of pathophysiology of ischemic nephropathy
| Project/Area Number |
16K15471
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
Itoh Hiroshi 慶應義塾大学, 医学部(信濃町), 教授 (40252457)
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| Co-Investigator(Kenkyū-buntansha) |
久保 亜紀子 慶應義塾大学, 医学部(信濃町), 特任講師 (50455573)
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| Research Collaborator |
MIYASHITA Kazutoshi 慶應義塾大学, 医学部, 専任講師 (50378759)
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| Project Period (FY) |
2016-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 質量分析イメージング / アデノシン / ATP / 腎臓 / 代謝産物可視化 / 急性腎不全 / 腎虚血 |
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| Outline of Final Research Achievements |
The kidney plays an essential role in the maintenance of physiological homeostasis of fluid and electrolytes in the body. Adenosine is a well known regulator of renal function and blood flow; however, the normal distribution of adenosine in the kidney has not been well elucidated. Matrix-assisted laser desorption/ionization (MALDI) - imaging mass spectrometry (IMS) is a novel technology for visualizing the distributions of molecules in situ. Small metabolites in the kidney has not been examined by the method thus far. In the present study, we identified a remarkable accumulation of adenosine in outer stripes of outer medulla (OSOM). The local accumulation of adenosine in OSOM may play a significant role for the physiological functions of adenosine such as the regulation of interstitial blood flow in the kidney.
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Report
(2 results)
Research Products
(5 results)
