| Project/Area Number |
16K15493
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Gunma University |
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Principal Investigator |
Yamada Masanobu 群馬大学, 大学院医学系研究科, 教授 (90261833)
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| Co-Investigator(Kenkyū-buntansha) |
小澤 厚志 群馬大学, 大学院医学系研究科, 助教 (10573496)
佐藤 哲郎 群馬大学, 医学部附属病院, 講師 (40302484)
中島 康代 群馬大学, 医学部附属病院, 助教 (70707017)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 中枢性甲状腺機能低下症 / 潜在性 / TRHノックアウトマウス / 血清TSH |
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| Outline of Final Research Achievements |
Subclinical hypothyroidism is drawing attention as a risk factor for the development of high LDL cholesterolaemia and cardiovascular disorders. We have discovered a new disease "subclinical central hypothyroidism" from the study of more than 300 pituitary tumors. Even in overt central hypothyroidism, the serum TSH level was within the reference range and can not be a diagnostic or therapeutic index. In this study, we have attempted to establish a diagnostic method to detect serum abnormal TSH using sample specimens and TRH knockout mice as model animals and finally investigate involvement of subclinical central hypothyroidism in lifestyle-related diseases .
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