Clonal evolution of tumor-infiltrating cells in T-cell lymphomas
| Project/Area Number |
16K15497
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
CHIBA Shigeru 筑波大学, 医学医療系, 教授 (60212049)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | T細胞リンパ腫 / TET2 / RHOA / クローン進化 / 支持環境細胞 / 前がん細胞 |
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| Outline of Final Research Achievements |
We previously identified that multistep acquisition of mutations are the important mechanisms for T-cell lymphomas. Mutations in TET2 gene, encoding an epigenetic modifier are the key for evolution of premalignant cells. The RHOA mutations are the driver for development of T-lineage tumor cells from premalignant cells. In this study, we established a mouse model showing that the tumors are supported by tumor-infiltrating cells evolved from premalignant cells.
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Report
(3 results)
Research Products
(31 results)
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[Journal Article] Droplet digital PCR assay and PNA-LNA clamp method for RHOA mutation detection in angioimmunoblastic T-cell lymphoma2018
Author(s)
Tanzima Nuhat S, Sakata-Yanagimoto M, Komori D, Hattori K, Suehara Y, Fukumoto K, Fujisawa M, Kusakabe M, Matsue K, Wakamatsu H, Shimadzu M, Chiba S
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Journal Title
Cancer Sci
Volume: -
Issue: 5
Pages: 1682-1689
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Activation of RHOA-VAV1 signaling in angioimmunoblastic T-cell lymphoma2017
Author(s)
Fujisawa M., Sakata-Yanagimoto M., Nishizawa S., Komori D., Gershon P., Kiryu M., Tanzima S., Fukumoto K., Enami T., Muratani M., Yoshida K., Ogawa S., Matsue K., Nakamura N., Takeuchi K., Izutsu K., Fujimoto K., Teshima T., Miyoshi H., Gaulard P., Ohshima K., Chiba S.
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Journal Title
Leukemia
Volume: 32
Issue: 3
Pages: 694-702
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Identification of cell-type-specific mutations in nodal T-cell lymphomas.2017
Author(s)
Nguyen TB, Sakata-Yanagimoto M, Asabe Y, Matsubara D, Kano J, Yoshida K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Izutsu K, Nakamura N, Takeuchi K, Miyoshi H, Ohshima K, Minowa T, Ogawa S, Noguchi M, Chiba S.
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Journal Title
Blood Cancer Journal
Volume: 7
Issue: 1
Pages: e516-e516
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Clinicopathologic analysis of angioimmunoblastic T-cell lymphoma with or without RHOA G17V mutation using formalin-fixed paraffin-embedded sections.2016
Author(s)
Nagao R, Kikuti YY, Carreras J, Kikuchi T, Miyaoka M, Matsushita H, Kojima M, Ando K, Sakata-Yanagimoto M, Chiba S, Nakamura N.
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Journal Title
Am J Surg Pathol
Volume: 40
Issue: 8
Pages: 1041-50
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] MYD88 (L265P) mutation is associated with an unfavourable outcome of primary central nervous system lymphoma.2016
Author(s)
Hattori K, Sakata-Yanagimoto M, Okoshi Y, Goshima Y, Yanagimoto S, Nakamoto-Matsubara R, Sato T, Noguchi M, Takano S, Ishikawa E, Yamamoto T, Matsumura A, Chiba S.
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Journal Title
Br J Haematol
Volume: -
Issue: 3
Pages: 492-494
DOI
Related Report
Peer Reviewed / Open Access
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