| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
USP10 promotes the conversion of ubiquitinated protein oligomers into aggresomes, and suppresses the cytotoxicity of ubiquitinated protein oligomers. 2) p62 binds to various ubiquitinated proteins and induces protein aggregate formation. USP10 binds to p62 and augments p62-induced protein aggregation. 3) Tau is a pathogenic protein of Alzheimer's disease (AD). USP10 induces Tau-positive stress granule formation, which initiates Tau aggregation in AD. 4) USP10 is a factor for initiating the formation of Lewy bodies (α-synuclein aggregates) in Parkinson's disease.
Protein aggregates are involved in the onset of various diseases including neurodegenerative and neoplastic diseases. The present study suggested that USP10 is involved in the formation of protein aggregates through the formation of stress granules and aggresomes.
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