Reconstiution of functional artificail bone marrow niche via induction of mesenchymal stromal cell division
| Project/Area Number |
16K15504
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Kumamoto University |
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Principal Investigator |
Takizawa Hitoshi 熊本大学, 国際先端医学研究機構, 特別招聘准教授 (10630866)
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| Co-Investigator(Renkei-kenkyūsha) |
Fumio Arai 九州大学, 医学研究院, 教授 (90365403)
Ryuji Yokokawa 京都大学, 工学研究科, 准教授 (10411216)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 間葉系幹細胞 / 間葉系ストローマ細胞 |
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| Outline of Final Research Achievements |
Blood forming hematopoietic stem cells (HSCs) are maintained within bone marrow microenvironment, often called niche consisting of bone forming mesenchymal stromal cells (MSC) that secrete various factors. here, we have successfully generated an artificial human bone marrow niche by engrafting human MSCs into mice that can maintain functional human HSCs.
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Report
(3 results)
Research Products
(3 results)
