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Reconstiution of functional artificail bone marrow niche via induction of mesenchymal stromal cell division

Research Project

Project/Area Number 16K15504
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Hematology
Research InstitutionKumamoto University

Principal Investigator

Takizawa Hitoshi  熊本大学, 国際先端医学研究機構, 特別招聘准教授 (10630866)

Co-Investigator(Renkei-kenkyūsha) Fumio Arai  九州大学, 医学研究院, 教授 (90365403)
Ryuji Yokokawa  京都大学, 工学研究科, 准教授 (10411216)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords間葉系幹細胞 / 間葉系ストローマ細胞
Outline of Final Research Achievements

Blood forming hematopoietic stem cells (HSCs) are maintained within bone marrow microenvironment, often called niche consisting of bone forming mesenchymal stromal cells (MSC) that secrete various factors. here, we have successfully generated an artificial human bone marrow niche by engrafting human MSCs into mice that can maintain functional human HSCs.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2018 2017 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Engineered humanized bone organs maintain human hematopoiesis in vivo,2018

    • Author(s)
      1.Fritsch K, Pigeot S, Bourgine PE, Feng X, Schroeder T, Martin I, Manz MG, Takizawa H
    • Journal Title

      Experimental Hematology

      Volume: 61 Pages: 45-51.e5

    • DOI

      10.1016/j.exphem.2018.01.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Humanization of bone marrow niche for better maintenance of human hematopoiesis in xenograft model2017

    • Author(s)
      Xiaomin Feng1 Kristin Fritsch, Sebastien Pigeot, Yuichiro Arima, Koichi Nishiyama, Ivan Martin, Markus G. Manz, Hitoshi Takizawa
    • Organizer
      Japanese society of hematology
    • Related Report
      2017 Annual Research Report
  • [Presentation] Pr o spe c t ive I s o lat i on o f Human Mesenchymal Stromal Cell Progenitor2016

    • Author(s)
      Xiaomin Feng
    • Organizer
      日本免疫学会
    • Place of Presentation
      沖縄
    • Year and Date
      2016-12-05
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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