Identification and characterization of biological targets of chemical expander for hematopoietic stem cells

• Project/Area Number: 16K15507
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Hematology
• Research Institution: National Center for Global Health and Medicine
• Principal Investigator: Takubo Keiyo 国立研究開発法人国立国際医療研究センター, その他部局等, 生体恒常性プロジェクト長 (50502788)
• Research Collaborator: KOBAYASHI Hiroshi ; MORIKAWA Takayuki ; KARIGANE Daiki ; TAMAKI Shinpei ; HARAGUCHI Miho
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 造血幹細胞 / 幹細胞増幅

Outline of Final Research Achievements

Hematopoietic stem cells (HSCs) produce all the hematopoietic lineages after birth. HSCs are utilized for transplantation therapy for various hematological malignancies. Due to the limited source of donor HSCs, the development of HSC expansion method is highly required. Recently, several chemical expander for HSCs are reported. However, the endogenous targets for these expanders have not reported so far. In this study, we tried to identify the targets for the HSC expanders, and characterized the functions of the targets in hematopoietic stem cells.

Research Products

• [Journal Article] Abnormal hematopoiesis and hematopoietic stem cell niche (2017)
  • Author(s): 田久保 圭誉、森川 隆之、小林 央
  • Journal Title: Rinsho Ketsueki Volume: 58 Issue: 10 Pages: 1844-1850
  • DOI: 10.11406/rinketsu.58.1844
  • NAID: 130006132651
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed
• [Journal Article] Use of Imaging Techniques to Illuminate Dynamics of Hematopoietic Stem Cells and Their Niches (2017)
  • Author(s): Morikawa Takayuki、Takubo Keiyo
  • Journal Title: Frontiers in Cell and Developmental Biology Volume: 5 Pages: 62-62
  • DOI: 10.3389/fcell.2017.00062
  • Peer Reviewed / Open Access
• [Journal Article] Metabolic regulation of hematopoietic and leukemic stem/progenitor cells under homeostatic and stress conditions (2017)
  • Author(s): Karigane Daiki、Takubo Keiyo
  • Journal Title: International Journal of Hematology Volume: 106 Issue: 1 Pages: 18-26
  • DOI: 10.1007/s12185-017-2261-x
  • Peer Reviewed
• [Journal Article] Quiescence of adult oligodendrocyte precursor cells requires thyroid hormone and hypoxia to activate Runx1. (2017)
  • Author(s): Tokumoto Y, Tamaki S, Kabe Y, Takubo K, Suematsu M
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 1019-1019
  • DOI: 10.1038/s41598-017-01023-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T, Takubo K. (2016)
  • Author(s): Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T, Takubo K.
  • Journal Title: Cell Stem Cell Volume: 19 Issue: 2 Pages: 192-204
  • DOI: 10.1016/j.stem.2016.05.013
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Remarks] 国立国際医療研究センター研究所生体恒常性プロジェクト
  • URL: http://www.rincgm.jp/department/pro/04/