| Project/Area Number |
16K15518
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Infectious disease medicine
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| Research Institution | Osaka University |
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Principal Investigator |
Yamasaki Seiji 大阪大学, 産業科学研究所, 助教 (70757301)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 感染症 / 排出ポンプ / 細菌 / 抗生物質 / トランスポーター / 多剤耐性菌 / 薬剤耐性 / 抗菌薬 |
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| Outline of Final Research Achievements |
As a result of this research, as techniques for identifying the physiological substrate of bacterial drug efflux pump, I established simple and rapid methods using various fluorescent substrates.
Through research on bacterial drug efflux pumps utilizing this technique, I elucidated the third route excreting cationic planar aromatic small molecules.
In addition, I finded out drug efflux pump inhibitor candidates involved in bacterial pathogenicity by using inhibitor screening method (Japanese Patent Application No. 2016-028653). These are useful for treatment of infectious diseases.
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