Manipulation of pathogenic memory T cells for development of novel treatment for food allergy
| Project/Area Number |
16K15524
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Gifu University |
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Principal Investigator |
MAEKAWA Yoichi 岐阜大学, 大学院医学系研究科, 教授 (10294670)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 病原性メモリーCD4 T細胞 / Notchシグナル / 免疫記憶 / メモリーCD4 T細胞 / 抗体による除去に抵抗性 / アレルギー / メモリーT細胞 / 病原性メモリー |
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| Outline of Final Research Achievements |
We examined the effect of depletion of food allergen-specific memory CD4 T cells (FA-memory T cells) for complete diminishment of recurrence of food allergy. When the allergen-immunized mice were treated with Notch signal inhibitor, we found that food allergy-related symptoms, diarrhea and anaphylaxis-induced death, were improved in these mice. However, we were not able to confirm the depletion of FA-memory T cells in those mice. On the other hand, we identified the unique memory-like CD4 T cells that were resistant to anti-CD4 antibody-dependent depletion. Furthermore, we found that those depletion-resistant CD4 T cells seem to contain FA-memory T cells to induce the recurrence of food allergy.
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Report
(3 results)
Research Products
(7 results)
