| Project/Area Number |
16K15531
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
水野 洋介 埼玉医科大学, 医学部, 講師 (30406532)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | mitochondria / noncoding RNA / ミトコンドリア / ミトコンドリア病 / 非コードRNA / 呼吸鎖酵素 / マイクロRNA / ミトコンドリア内RNA |
|---|
| Outline of Final Research Achievements |
The cause of mitochondrial diseases could be explained not only by the mutations of mitochondrial protein coding genes but also by the changing of quality and quantity of noncoding RNAs that could regulate mitochondrial genes. In this study, we performed expression analysis of noncoding RNAs using model cells in which specific mitochondrial genes are inhibited by RNA interference and CRISPR. As a result, we detected several noncoding RNAs including micro RNAs that were differentially expressed by inhibition of mitochondrial genes. We estimate that those include the functional regulatory noncoding RNAs which regulate mitochondrial function.
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