| Project/Area Number |
16K15541
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
会津 隆幸 弘前大学, 医学研究科, 助教 (00400135)
滝吉 典子 弘前大学, 医学部附属病院, 助教 (30568895)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 自己免疫 / 遺伝子 / 皮膚 / 水疱 / ELISA / イムノクロマトグラフィー / ベットサイド / ベッドサイド / 類天疱瘡 / 免疫 / クロマト / 唾液 / 抗体 |
|---|
| Outline of Final Research Achievements |
Bullous pemphigoid is a skin disease which shows generalized blisters and occurs mostly in the elderly. This disease is characterized by autoantibodies to basement membrane zone and considered as autoimmune blistering disease. Immunofluorescence study and ELISA analysis using serum usually take long time and we tried to generate a simple and quick method to diagnose bullous pemphigoid. In this study, we demonstrated that saliva is useful for Immunofluorescence study and ELISA analysis of BP180. Furthermore, we development ELISA method and also immunochromatographic method using several recombinant peptides of BP180.
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