Development of new therapies and eluciation of pathomechanisms for psoriatic arthritis wich focusing on IL-36 and TLR-4
| Project/Area Number |
16K15546
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 関節症性乾癬 / IL-36 / TLR-4 / リポ多糖 / IL36RNノックアウトマウス / 膿疱性乾癬 / TLR4 / モデルマウス / 骨髄由来間葉系細胞 |
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| Outline of Final Research Achievements |
Bone erosion or joint deformity emerges in 2 years in 50% of patients with psoriatic arthritis (PsA). Dermatologist should make diagnosis and treat early PsA because 70% of patients with PsA shows skin lesions preceding arthritis. But pathomechanisms of PsA remains unknown. In this study, we focused on Toll-like receptor-4(TLR-4) for the pathomechanisms. Lipopolysaccharide (LPS), a TLR-4 ligand, was injected on a foot pad of IL36RN knock out (KO) mouse. Then, outstanding swelling and thickness of foot was observed in the IL36RN KO mouse compering in the wild mouse. In conclusion we made a PsA model using the IL36RN KO mouse with TLR-4 ligand injection on the food pad. Furthermore, we proved that TLR-4 inhibitor ameliorates the symptom of the PsA model.
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Report
(3 results)
Research Products
(55 results)
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[Journal Article] Biallelic Mutations in KDSR Disrupt Ceramide Synthesis and Result in a Spectrum of Keratinization Disorders Associated with Thrombocytopenia.2017
Author(s)
Takeichi T, Torrelo A, Lee JYW, Ohno Y, Lozano ML, Kihara A, Liu L, Yasuda Y, Ishikawa J, Murase T, Rodrigo AB, Fernández-Crehuet P, Toi Y, Mellerio J, Rivera J, Vicente V, Kelsell DP, Nishimura Y, Okuno Y, Kojima D, Ogawa Y, Sugiura K, Simpson MA, McLean WHI, Akiyama M, McGrath JA.
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Journal Title
J Invest Dermatol.
Volume: 137
Issue: 11
Pages: 2344-2353
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Enhancement of Individual Differences in Proliferation and Differentiation Potentials of Aged Human Adipose-Derived Stem Cells.2017
Author(s)
Kawagishi-Hotta M, Hasegawa S, Igarashi T, Yamada T, Takahashi M, Numata S, Kobayashi T, Iwata Y, Arima M, Yamamoto N, Yagami A, Nakata S, Uzawa T, Matsunaga K, Sugiura K, Akamatsu H.
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Journal Title
Regenerative Therapy
Volume: 6
Pages: 29-40
Related Report
Peer Reviewed
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[Journal Article] Pityriasis rubra pilaris type V as an auto inflammatory disease by CARD14 mutations.2017
Author(s)
Takeichi T, Sugiura K, Nomura T, Sakamoto T, Ogawa Y, Oiso N, Futei Y, Fujisaki A, Koizumi A, Aoyama Y, Nakajima K, Hatano Y, Hayashi K, Akemi Ishida-Yamamoto A, Fujiwara S, Sano S, Iwatsuki K, Kawada A, Suga Y, Shimizu H, McGrath JA, Akiyama M.
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Journal Title
JAMA Dermatol
Volume: 153
Issue: 1
Pages: 66-70
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Novel and recurrent ATP2A2 mutations in Japanese patients with Darier’s disease2016
Author(s)
Noda K, Takeichi T, Okuno Y, Takama H, Miura S, Kagami S, Hino H, Nakamura Y, Fujio Y, Konohana I, Otani A, Mukai H, Sugiura K, Akiyama M.
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Journal Title
Nagoya Journal of Medical Science
Volume: 78
Issue: 4
Pages: 485-492
DOI
NAID
ISSN
2186-3326
URL
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Dyschromatosis symmetrica hereditaria and Aicardi-Goutires syndrome 6 are phenotypic variants caused by ADAR1 mutations.2016
Author(s)
Kono M, Matsumoto F, Suzuki Y, Suganuma M, Saitsu H, Ito Y, Fujiwara S, Matsumoto K, Moriwaki S, Matsumoto N, Tomita Y, Sugiura K, Akiyama M.
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Journal Title
J Invest Dermatol.
Volume: 136
Issue: 4
Pages: 875-8
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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