Genomic analysis of Common marmosets and identification of primate models for psychiatric disorders
| Project/Area Number |
16K15559
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Nagoya University |
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Principal Investigator |
Ozaki Norio 名古屋大学, 医学系研究科, 教授 (40281480)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | コモンマーモセット / CNV / 精神疾患 |
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| Outline of Final Research Achievements |
To elucidate the etiology of psychiatric disorders, it is critical to establish appropriate animal models reflecting their pathogenesis. Common marmosets (Callithrix jacchus) have advantages as animal models for psychiatric disorders because the higher function of their brain is similar to that of humans. In this study, we performed genomic analysis of marmosets and aimed to identify pathogenic copy number variations (CNVs) associated the risk of psychiatric disorders, and to examine phenotypes of individuals with these CNVs. As a result of the analysis of 47 marmoset individuals, we identified a very large deletion (8.4 Mb) at chromosome 16 in one individual. CNVs of this size may be associated with the risk of psychiatric disorders in humans. However, we could not do any further examination because phenotype data for this individual was not available.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] High-resolution copy number variation analysis of schizophrenia in Japan.2017
Author(s)
Kushima I, Aleksic B, Nakatochi M, Shimamura T, Shiino T, Yoshimi A, Kimura H, Takasaki Y, Wang C, Xing J, Ishizuka K, Oya-Ito T, Nakamura Y, Arioka Y, Maeda T, Yamamoto M, Yoshida M, Noma H, Hamada S, Morikawa M, Uno Y, Okada T, Iidaka T, Iritani S, Yamamoto T,
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Journal Title
Molecular Psychiatry
Volume: 22
Issue: 3
Pages: 430-440
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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