Analysis of interacting-partners of Nav1.1 in premature mouse brain
| Project/Area Number |
16K15564
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Nippon Medical School |
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Principal Investigator |
OGIWARA Ikuo 日本医科大学, 医学部, 准教授 (30373286)
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| Co-Investigator(Renkei-kenkyūsha) |
KANEDA Makoto 日本医科大学, 大学院医学研究科, 教授 (30214480)
ISHII Toshiyuki 日本医科大学, 医学部, 助教 (10643140)
AKAGI Takumi 日本医科大学, 医学部, 助教 (50192878)
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| Research Collaborator |
USUI Sumiko
Suzuki Chiaki
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | てんかん / ナトリウムチャネル / 脳・神経 / 電位依存性ナトリウムチャネル |
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| Outline of Final Research Achievements |
Dravet syndrome is an epileptic encephalopathy, mainly caused by mutations in the SCN1A gene encoding a voltage-gated sodium channel Nav1.1. This study was aimed to identify interacting-partners of Nav1.1. Using co-precipitation and tandem-mass spectrometry, this study reported three novel interacting-partners of Nav1.1 in premature mouse brain, which seemed to be expressed in inhibitory neurons as Nav1.1 did.
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Report
(3 results)
Research Products
(12 results)
