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Analysis of interacting-partners of Nav1.1 in premature mouse brain

Research Project

Project/Area Number 16K15564
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionNippon Medical School

Principal Investigator

OGIWARA Ikuo  日本医科大学, 医学部, 准教授 (30373286)

Co-Investigator(Renkei-kenkyūsha) KANEDA Makoto  日本医科大学, 大学院医学研究科, 教授 (30214480)
ISHII Toshiyuki  日本医科大学, 医学部, 助教 (10643140)
AKAGI Takumi  日本医科大学, 医学部, 助教 (50192878)
Research Collaborator USUI Sumiko  
Suzuki Chiaki  
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsてんかん / ナトリウムチャネル / 脳・神経 / 電位依存性ナトリウムチャネル
Outline of Final Research Achievements

Dravet syndrome is an epileptic encephalopathy, mainly caused by mutations in the SCN1A gene encoding a voltage-gated sodium channel Nav1.1. This study was aimed to identify interacting-partners of Nav1.1. Using co-precipitation and tandem-mass spectrometry, this study reported three novel interacting-partners of Nav1.1 in premature mouse brain, which seemed to be expressed in inhibitory neurons as Nav1.1 did.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (12 results)

All 2018 2017 2016

All Journal Article (7 results) (of which Peer Reviewed: 2 results) Presentation (5 results) (of which Invited: 1 results)

  • [Journal Article] Impairments in social novelty recognition and spatial memory in mice with conditional deletion of Scn1a in parvalbumin-expressing cells.2018

    • Author(s)
      Tatsukawa T, Ogiwara I, Mazaki E, Shimohata A, Yamakawa K.
    • Journal Title

      Neurobiology of Disease

      Volume: 112 Pages: 24-34

    • DOI

      10.1016/j.nbd.2018.01.009

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2.2017

    • Author(s)
      Yamagata T, Ogiwara I, Mazaki E, Yanagawa Y, Yamakawa K.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 491 Issue: 4 Pages: 1070-1076

    • DOI

      10.1016/j.bbrc.2017.08.013

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of transgenic mouse lines that express the green fluorescent protein under the control of the Scn1a promoters.2017

    • Author(s)
      Ogiwara I, Tatsukawa T, Mazaki E, Yamakawa K.
    • Journal Title

      Annual Report of the Japan Epilepsy Research Foundation

      Volume: 28 Pages: 47-54

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Dravet syndrome pathophysiology: lessons from mouse models.2017

    • Author(s)
      Ogiwara I.
    • Journal Title

      Annual Report of the Japan Epilepsy Research Foundation

      Volume: 28 Pages: 11-20

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Dravet syndrome pathophysiology: lessons from mouse models2017

    • Author(s)
      Ogiwara, I.
    • Journal Title

      Annual Report of the Japan Epilepsy Research Foundation

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
  • [Journal Article] Generation of transgenic mouse lines that express the green fluorescent protein under the control of the Scn1a promoters2017

    • Author(s)
      Ogiwara, I., Tatsukawa, T., Mazaki, E., Yamakawa, K.
    • Journal Title

      Annual Report of the Japan Epilepsy Research Foundation

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
  • [Journal Article] Transplantation of medial ganglionic eminence derived GABAergic interneurons in Dravet syndrome model mice2016

    • Author(s)
      Tatsukawa, T., Ogiwara, I., Mazaki, E., Yamakawa, K.
    • Journal Title

      Annual Report of the Japan Epilepsy Research Foundation

      Volume: 27 Pages: 93-100

    • Related Report
      2016 Research-status Report
  • [Presentation] 代謝型グルタミン酸受容体6型の極性輸送・膜発現に関わる分子機構の解析2017

    • Author(s)
      赤木巧、レイディリップ、木山裕子、荻原郁夫、金田誠
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(静岡県)浜松市
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] SCN1A遺伝子変異マウスを用いたDravet症候群発症機序解明2017

    • Author(s)
      荻原郁夫
    • Organizer
      てんかん治療研究振興財団第22回研究報告会
    • Place of Presentation
      千里阪急ホテル(大阪府豊中市)
    • Year and Date
      2017-03-03
    • Related Report
      2016 Research-status Report
  • [Presentation] Dravet症候群発症機構解明のためのSCN1A遺伝子発現可視化マウスの開発2017

    • Author(s)
      荻原郁夫、立川哲也、真崎恵美、山川和弘
    • Organizer
      てんかん治療研究振興財団第22回研究報告会
    • Place of Presentation
      千里阪急ホテル(大阪府豊中市)
    • Year and Date
      2017-03-03
    • Related Report
      2016 Research-status Report
  • [Presentation] 電位依存性ナトリウムチャネルNav1.1と相互作用するタンパクの探索2017

    • Author(s)
      荻原郁夫
    • Organizer
      第51回日本てんかん学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Scn1a変異マウスを用いた病態研究(Dravet症候群のモデルとして)2017

    • Author(s)
      荻原郁夫
    • Organizer
      第51回日本てんかん学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited

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Published: 2016-04-21   Modified: 2019-03-29  

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