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Gut microbiota and depressive symptoms in adolescence -effect of perinatal factors-

Research Project

Project/Area Number 16K15566
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionThe University of Tokyo (2017-2018)
Tokyo Metropolitan Institute of Medical Science (2016)

Principal Investigator

ANDO Shuntaro  東京大学, 医学部附属病院, 講師 (20616784)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords抑うつ / 腸内細菌叢 / 思春期 / 腸内細菌
Outline of Final Research Achievements

We conducted a visiting survey on the general adolescent child cohort. Children had their stool collected at home, then we collected them at the survey site. The analyzer company measured the bacterial flora of the fecal samples. The primary caregiver was asked to answer a self-administered questionnaire (Child Behavior Checklist) to evaluate depressive symptoms in adolescent children.
As a result, the gut microbiota of 314 adolescent children could be identified. There was no significant relationship between the experience of caesarean section and the gut microbiota of adolescent children. In addition, breastfeeding duration did not show a significant relationship with depressive symptoms. The high proportion of specific intestinal flora was associated with the strength of depressive symptoms in adolescent children. This relationship was also significant after adjusting for gender and age.

Academic Significance and Societal Importance of the Research Achievements

本研究は、一般思春期児童を対象に腸内細菌叢と抑うつ症状の関係を検討した初めての研究である。その結果、思春期における特定の腸内細菌叢の比率と抑うつ症状が関係することが示唆された。本研究成果から、思春期における抑うつ症状の発生メカニズム解明が進むことが期待される。また、今後は因果関係の解明に迫る銃弾研究も求められる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (11 results)

All 2019 2018 2017 2016 Other

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] Cohort profile: The Tokyo teen cohort study (TTC)2019

    • Author(s)
      Ando Shuntaro、Nishida Atsushi、Yamasaki Syudo、Koike Shinsuke、Morimoto Yuko、Hoshino Aya、Kanata Sho、Fujikawa Shinya、Endo Kaori、Usami Satoshi、Furukawa Toshiaki A、Hiraiwa-Hasegawa Mariko、Kasai Kiyoto、TTC Scientific and Data Collection Team
    • Journal Title

      International Journal of Epidemiology

      Volume: 48 Issue: 5 Pages: 1414

    • DOI

      10.1093/ije/dyz033

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Help-seeking intention for depression in early adolescents: Associated factors and sex differences2018

    • Author(s)
      Ando Shuntaro、Nishida Atsushi、Usami Satoshi、Koike Shinsuke、Yamasaki Syudo、Kanata Sho、Fujikawa Shinya、Furukawa Toshiaki A、Fukuda Masato、Sawyer Susan M、Hiraiwa-Hasegawa Mariko、Kasai Kiyoto
    • Journal Title

      Journal of Affective Disorders

      Volume: 238 Pages: 359

    • DOI

      10.1016/j.jad.2018.05.077

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 東京ティーンコホート2018

    • Author(s)
      安藤俊太郎、西田淳志、山崎修道、金田渉、森本裕子、長谷川眞理子、笠井清登
    • Journal Title

      日本社会精神医学会雑誌

      Volume: 印刷中

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 疫学研究発展の長期展望2017

    • Author(s)
      森田正哉、金田渉、八木智子、藤川慎也、遠藤香織、西田淳志、安藤俊太郎
    • Journal Title

      精神科

      Volume: 3 Pages: 227-231

    • Related Report
      2017 Research-status Report
  • [Journal Article] Strengthening community mental health services in Japan.2017

    • Author(s)
      Kasai K, Ando S, Kanehara A, Kumakura Y, Kondo S, Fukuda M, Kawakami N, Higuchi T.
    • Journal Title

      Lancet Psychiatry

      Volume: 4 Issue: 4 Pages: 268-270

    • DOI

      10.1016/s2215-0366(16)30373-x

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Appetite loss as a potential predictor of suicidal ideation and self-harm in adolescents: A school-based study2017

    • Author(s)
      Kitagawa Y., Ando S., Yamasaki S., Foo J.C., Okazaki Y., Shimodera S., Nishida A., Togo F. & Sasaki T.
    • Journal Title

      Appetite

      Volume: 111 Pages: 7-11

    • DOI

      10.1016/j.appet.2016.12.026

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 思春期の精神疾患のために一般精神科医ができることは?2016

    • Author(s)
      安藤俊太郎、金田渉、金生由紀子
    • Journal Title

      精神科

      Volume: 4 Pages: 338-342

    • Related Report
      2016 Research-status Report
  • [Presentation] 地域思春期児童の前向き調査:東京ティーンコホート2018

    • Author(s)
      安藤俊太郎
    • Organizer
      第59回 日本児童青年精神医学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The Tokyo Teen Cohort study: an adolescent cohort study with life course approach2017

    • Author(s)
      Shuntaro Ando
    • Organizer
      The 21st International Epidemiological Association (IEA) World Congress of Epidemiology (WCE2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Tokyo Teen Cohort Study2017

    • Author(s)
      Shuntaro Ando
    • Organizer
      The 16th Congress of the International Federation of Psychiatric Epidemiology
    • Related Report
      2017 Research-status Report
  • [Remarks] 公益財団法人 東京都医学総合研究所 心の健康プロジェクト

    • URL

      http://www.igakuken.or.jp/project/detail/mental-health.html

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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