A novel cancer treatment by a combination of irradiation and application of iPS cells
| Project/Area Number |
16K15573
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Tsuboi Koji 筑波大学, 医学医療系, 教授 (90188615)
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| Co-Investigator(Kenkyū-buntansha) |
梨井 康 国立研究開発法人国立成育医療研究センター, 移植免疫研究室, 室長 (60321890)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | Radiotherapy / Dendritic cells / anti-PD1 antibody / abscopal effect / 照射線治療 / 免疫 / 樹状細胞 / 抗PD-1抗体 / 免疫原性細胞死 / がん / 放射線 / 腫瘍免疫 / PD-1 |
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| Outline of Final Research Achievements |
Local irradiation to tumors may act as antitumor immune adjuvant. We tested whether a combination of local injection of bone marrow or iPS-cells derived dendritic cells (DCs) and intraperitoneal administration of anti-PD-1 antibody after radiotherapy was effective or not to induce antitumor immune response. X-rays and proton beams were used as radiotherapy.
After irradiation to B16 melanoma cells implanted subcutaneously at the left thigh of C57BL/6 mice, DCs were injected to the tumor site 4 times, and anti-PD-1 antibody were administrated 3 times. To examine the abscopal effect, tumor cells were inoculated to the right thigh as metastatic tumors, and only the primary tumors on the left side were treated. As a result, the growth of both the primary and the metastatic tumors were significantly inhibited, extending survival times of mice significantly. There were no significant differences in effects between X-rays and protons, and between BM- and iPS-DCs.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Registration error of the liver CT using deformable image registration of MIM Maestro and Velocity AI.2017
Author(s)
Fukumitsu N, Nitta K, Terunuma T, Okumura T, Numajiri H, Oshiro Y, Ohnishi K, Mizumoto M, Aihara T, Ishikawa H, Tsuboi K, Sakurai H
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Journal Title
BMC Med Imaging
Volume: 17
Pages: 30-30
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A comparative study of dose distribution of pbt, 3d-crt and imrt for pediatric brain tumors2017
Author(s)
Takizawa D, Mizumoto M, Yamamoto T, Oshiro Y, Fukushima H, Fukushima T, Terunuma T, Okumura T, Tsuboi K, Sakurai H.
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Journal Title
Radiat Oncol
Volume: 12(1)
Pages: 1-7
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Long-term outcomes of proton beam therapy in patients with previously untreated hepatocellular carcinoma.2017
Author(s)
Fukuda K, Okumura T, Abei M, Fukumitsu N, Ishige K, Mizumoto M, Hasegawa N, Numajiri H, Ohnishi K, Ishikawa H, Tsuboi K, Sakurai H, Hyodo I
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Journal Title
Cancer Sci.
Volume: 108
Pages: 497-503
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A prospective multicenter single-arm clinical trial of bevacizumab for patients with surgically untreatable symptomatic brain radiation necrosis2016
Author(s)
Furuse M, Nonoguchi N, Kuroiwa T, Miyamoto S, Arakawa Y, Shinoda J, Miwa K, Iuchi T, K, Houkin K, Terasaka S, Tabei Y, Nakamura H, Nagane M, Sugiyama K, Terasaki M, Abe T, Narita Y, Saito N, Mukasa A, Ogasawara K, Beppu T, Kumabe T, Nariai T, Tsuyuguchi N, Nakatani E, Kurisu S, Naakagawa Y, Miyatake S.
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Journal Title
Neurooncol Pract.
Volume: 0
Pages: 272-280
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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