| Project/Area Number |
16K15574
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | MRI / CEST / 薬剤モニタリング / 脳虚血 / 神経機能画像学 / 磁気共鳴学 |
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| Outline of Final Research Achievements |
Using the principle of chemical exchange saturation transfer MRI (CEST MRI), we developed the newly in vivo drug distribution monitoring procedure in brain. Frufenamic acid was chosen as a target drug because of its protective effect for focal cerebral ischemia on mouse model of cerebral ischemia. The developed procedure, chronological changes of Frufenamic acid distribution in brain could be monitored non-invasively, if Frufenamic acid was administered before ischemia. On contrary, concentration of Frufenamic acid is very low if it was administered after the induction of ischemia, which ceased its protective effect against ischemia. Brain concentration of the drug is fundamental to assess its effect for brain. The developed procedure enables in vivo non-invasive monitoring of the distribution of a target drug.
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| Academic Significance and Societal Importance of the Research Achievements |
本手法の開発により、薬剤動態の解析により標的とする組織集積性のもっとも高い薬剤投与方法の個人ごとの評価が可能となり「オーダーメード投薬」への道が開けると共に、新規治療法の開発への応用等、薬剤治療法の最適化に大きな効果が期待できる。
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