| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Overcoming the radioresistance of cancer is an important issue. However, regulatory factor for radiosensitivity of cells are still unclear. That is a major problem in radiation therapy. Therefore, we screened the genes involved in the regulation of radiation resistance of cancer cells and analyzed their mechanisms.
One of candidate genes induce radioresistance by the increase in antioxidant property through changing intracellular redox status. Cancer cells acquire antioxidant phenotypes through metabolic reprogramming including acceleration of pentose-phosphate pathway in a HIF-1 dependent manner. We expected that inhibitors targeting this gene will be used to overcome the radioresistance of cancer.
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