Trial of the radioisotope nano container production aimed to a radio-source therapy
Project/Area Number |
16K15579
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Radiation science
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Research Institution | Kyoto University |
Principal Investigator |
Ohtsuki Tsutomu 京都大学, 複合原子力科学研究所, 教授 (50233193)
|
Research Collaborator |
TAKAMIYA Koichi
SEKIMOTO Shun
SUEKI Keisuke
MASUNAGA Shinichiro
|
Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 線源内療法 / ナノコンテナ / 放射性同位元素 / フラーレン / ナノチューブ / 液体クロマトグラフィー / 内包フラーレン / 第一原理視乳レーション / テクネチウム-99m / 金-194 / α線β線核種 / ホットアトム / 医療用RI / 加速器 / 医療応用 |
Outline of Final Research Achievements |
Investigation on 99mTc@C60 and 194Au@C60 for nuclear medicine have done with nuclear recoil process. The formation of atom- incorporated fullerenes was investigated by using radionuclides produced by nuclear reactions. From the trace of the radioactivities of 99Mo/99mTc and 194Au after high-performance liquid chromatography, it was found that the formation of endohedral fullerenes in atoms of 99mTc@C60 and 194Au@C60 is possible by a recoil process following nuclear reactions. From first-principles molecular dynamics simulations using TOMBO, it is found that Mo and Au atoms are encapsulated through the center of a six-membered ring into C60, respectively, with 40 eV and 80 eV kinetic energy in the vertical direction. 100Mo becomes 99mTc after encapsulation. Experimentally, we also succeeded in synthesize 99mTc@C60 and 194Au@C60 by nuclear recoil reaction.
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Academic Significance and Societal Importance of the Research Achievements |
「核医学用99mTc@C60,194Au@C60の検討」では、反跳効果を利用してフラーレンに放射性同位元素が挿入可能かどうかしらべられた。さらに第一原理分子動力学シミュレーションより、Mo, Au原子をC60の6員環中央に垂直に衝突させた場合、Moは40 eVで、Auは80 eVで内包可能であることを見出した。100Moは内包後99mTcに変化するがケージ内に留まることが示唆された。我々は、原子核反跳効果を利用する実験でも99mTc@C60,194Au@C60が合成可能であることを見出した。線源内療法のための放射性同位元素ナノコンテナ製造が有望であることが示された。
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Study of fission using multi-nucleon transfer reactions2018
Author(s)
K. Nishio, K. Hirose, M. Vermeulen, H. Makii, R. Orlandi, K. Tsukada, M. Asai, A. Toyoshima, T.K. Sato, Y. Nagame, S. Chiba, Y. Aritomo, S. Tanaka, T. Ohtsuki, I. Tsekhanovich, C.M. Petrache, A. Andreyev
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Journal Title
EPJ Web of Conferences
Volume: 169
Pages: 00013-1
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A new detector system for the measurement of high-energy prompt gamma-rays for low-energy neutron induced fission2018
Author(s)
H. Makii, K. Nishio, K. Hirose, R. Orlandi, R. Leguillon, T. Ogawa, T. Soldner, F.-J. Hambsch, M. Aiche, A. Astier e, S. Czajkowski, R. Frost, S. Guo, U. Koster, L. Mathieu, T. Ohtsuki, C.M. Petrache, A. Pollitt, S. Sekimoto, K. Takamiya, I. Tsekhanovich
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Journal Title
Nuclear Instruments and Methods in Physics Research A
Volume: 906
Pages: 88-96
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Simultaneous measurement of neutron-induced fission and capture cross sections for 241Am at neutron energies below fission threshold.2017
Author(s)
K. Hirose, K. Nishio, H. Makii, I Nishinaka, S. Ota, T. Nagayama, N. Tamura, S. Goto, A. Andreyev, M. Vermeulen, S. Gilespie, C. Barton, A. Kimura, H. Harada, S. Meigo, S Chiba, T. Ohtsuki.
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Journal Title
Nuclear Instr. And Meth. A
Volume: 856
Pages: 133-138
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Role of Multichance Fission in the Description of Fission-Fragment Mass Distributions at High Energies2017
Author(s)
K. Hirose, K. Nishio, S. Tanaka, R. Leguillon, H. Makii, I Nishinaka, R. Orlandi, K. Tsukada, J. Smallcombe, M.J. Vermeulen, S Chiba, Y. Aritomo, T. Ohtsuki, K. Nakano, S. Araki, Y. Watanabe, R. Tatsuzawa, N. Takaki, N. Tamura, S. Goto, I. Tse khanovi ch, A.N. Andreyev
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Journal Title
Physical Review Letters
Volume: 119
Issue: 22
Pages: 222501-222501
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Study of F ission Using Multi-Nuceon T ransfer Re actions.2017
Author(s)
K. Nishio, K. Hirose, V. Mark, H. Makii, R. Orlandi, K. Tsukada, M. Asai, A. Toyoshima, T. K. Sato, Y. Nagame, S. Chiba, Y. Aritomo, S. Tanaka, T. Ohtsuki, I. Tsekhanovich, C. M. Petrache, A. Andreyev
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Journal Title
EPJ Web of Conferences
Volume: 163
Pages: 00041-00041
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Experimental fission study using multi-nucleon transfer reactions2017
Author(s)
K. Nishio, K. Hirose, R. Leguillon, H. Makii, R. Orlandi, K. Tsukada, J. Smallcombe, S. Chiba, Y. Aritomo, S. Tanaka, T. Ohtsuki, I. Tsekhanovich, C. M. Petrache, A. Andreyev
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Journal Title
EPJ Web of Conferences
Volume: 146
Pages: 04009-04009
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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