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Examination of Medical Radionuclides Production using an Electron Linear Accelerator

Research Project

Project/Area Number 16K15580
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionKyoto University

Principal Investigator

Sekimoto Shun  京都大学, 複合原子力科学研究所, 助教 (10420407)

Research Collaborator ITOSU Satoshi  
Tanaka Wataru  
ONO Yuichiro  
FUSHIMI Takuya  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords医療用放射性核種 / 電子線形加速器 / Cu-67 / Mo-99/Tc-99m / 核医学 / 制動放射線 / Ga-68 / Re-188 / 放射性医薬品
Outline of Final Research Achievements

The medical radionuclides Cu-67, Re-188, Ga-Ga, Rh-105, and Lu-177 were produced using bremsstrahlung photons generated by an electron linear accelerator. The activity of each radionuclide was examined by varying electron energies. Based on the experimental results, a possibility to supply the demand of each nuclide described above was discussed. The activity of Cu-67 is expected to be produced more efficiently by an electron linear accelerator than by the other accelerator, such as proton one.

Academic Significance and Societal Importance of the Research Achievements

本研究は、小型化が可能であるため、建設コストが安価な電子線形加速器で発生させる制動放射線を用いた効率的な医療用RI製造法の開発のための基礎検討であり、これまで国内では検討されていない斬新な方法を提案するものである。小型の電子線形加速器を使用した医療用RIの製造システムが実現できれば、各地方の拠点医療施設ごとにそれらを配備し、必要に応じた医療用RIの供給が可能となる。
現在、特にCu-67は、腫瘍の診断・治療薬の原料として、国内で安定供給が急務となっており、本研究で提案する方法により、安価にCu-67の安定供給を実現できれば、その意義は大きい。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (19 results)

All 2019 2018 2017 2016

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (16 results) (of which Int'l Joint Research: 7 results,  Invited: 1 results)

  • [Journal Article] Production of medical radioactive nuclides using an electron linear accelerator2018

    • Author(s)
      Takahiro Tadokoro, Yuichiro Ueno, Yuko Kani, Shun Sekimoto, Tsutomu Ohtsuki
    • Journal Title

      JAEA-Conf 2018-001 INDC(JPN)-204, Proceedings of the 2017 Symposium on Nuclear Data November 16-17,2017, Tokaimura, Ibaraki, Japan

      Volume: 1 Pages: 75-80

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new detector system for the measurement of high-energy prompt gamma-rays for low-energy neutron induced fission2018

    • Author(s)
      H. Makii, K. Nishio, K. Hirose, R. Orlandi, R. Leguillon, T. Ogawa, T. Soldner, F.-J. Hambsch, M. Aiche, A. Astier e, S. Czajkowski, R. Frost, S. Guo, U. Koster, L. Mathieu, T. Ohtsuki, C.M. Petrache, A. Pollitt, S. Sekimoto, K. Takamiya, I. Tsekhanovich
    • Journal Title

      Nuclear Instruments and Methods in Physics Research A

      Volume: 906 Pages: 88-96

    • DOI

      10.1016/j.nima.2018.07.055

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Separation and purification of Tc-99m from Mo-99 produced by electron linear accelerator2017

    • Author(s)
      Shun Sekimoto, Katsuyoshi Tatenuma, Yumi Suzuki, Akira Tsuguchi, Atsushi Tanaka, Takahiro Tadokoro, Yuko Kani, Yasumasa Morikawa, Asaki Yamamoto, Tsutomu Ohtsuki
    • Journal Title

      Journal of Radioanalytical and Nuclear Chemistry

      Volume: 311 Issue: 2 Pages: 1361-1366

    • DOI

      10.1007/s10967-016-4959-2

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Production of radioisotopes at Institute for Integrated Radiation and Nuclear Science, Kyoto University2019

    • Author(s)
      Tsutomu Ohtsuki, Shun Sekimoto, Makoto Inagaki, Koichi Takamiya, Yuichi Oki
    • Organizer
      RANC 2019(2nd International Conference on Radioanalytical and Nuclear Chemistry)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Production of medical radioisotopes using electron linear accelerator2019

    • Author(s)
      Makoto Inagaki, Shun Sekimoto, Takahiro Tadokoro, Yuichiro Ueno, Yuko Kani, Tsutomu Ohtsuki
    • Organizer
      RANC 2019(2nd International Conference on Radioanalytical and Nuclear Chemistry)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 放射化分析法を用いた固体地球化学試料中のハロゲン及び微量元素の定量2018

    • Author(s)
      関本 俊
    • Organizer
      2018日本放射化学会年会・第62回放射化学討論会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 炉内中性子誘導即発ガンマ線による核計装システムの基礎検討2018

    • Author(s)
      岡田 耕一,田所 孝広,伏見 篤,関本 俊,大槻 勤
    • Organizer
      2018日本原子力学会秋の大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] RADIOCHEMICAL AND INSTRUMENTAL NEUTRON ACTIVATION ANALYSIS USING KYOTO UNIVERSITY REACTOR2018

    • Author(s)
      Sekimoto, S. and Ohtsuki, T.
    • Organizer
      Methods & Applications of Radioanalytical Chemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mo-99/Tc-99m production using an electron linear accelerator2018

    • Author(s)
      Shun Sekimoto, Takahiro Tadokoro, Yuko Kani, Yuichiro Ueno, Tsutomu Ohtsuki
    • Organizer
      Tc&Re - ISTR2018 - International Symposium on Technetium and Rhenium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 電子線形加速器を利用した医療用核種製造システムの検討 (1)概要2018

    • Author(s)
      関本 俊、田所 孝広、上野 雄一郎、可児 祐子、蓼沼 克嘉、Jang Jaewoong、井上 佳徳、山本 昌志、上坂 充、大槻 勤
    • Organizer
      2018年原子力学会春の年会
    • Related Report
      2017 Research-status Report
  • [Presentation] クラウンエーテルを用いた化学交換法によるモリブデンの同位体分離2018

    • Author(s)
      田野城一希、加藤千図、大野剛、坂田周平、上原章寛、福谷哲、関本俊、大槻勤、藤井俊行
    • Organizer
      2018年原子力学会春の年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 電子線形加速器を利用したMo-99/Tc-99m製造システムにおける製造量評価2017

    • Author(s)
      関本 俊,田所 孝広,可児 祐子,上野 雄一郎,大槻 勤
    • Organizer
      日本原子力学会 2017年春の年会
    • Place of Presentation
      東海大学湘南キャンパス
    • Year and Date
      2017-03-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 荷電粒子放射化分析法の放射性核種分析への適用性検討 (2) 90Sr迅速分析の検討2017

    • Author(s)
      川上 智彦, 田仲 睦, 蓼沼 克嘉, 大島 真澄, 関本 俊, 大槻 勤
    • Organizer
      日本原子力学会 2017年春の年会
    • Place of Presentation
      東海大学湘南キャンパス
    • Year and Date
      2017-03-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 電子線形加速器を利用した医療用核種製造システムにおけるGe-68/Ga-68製造量の検討2017

    • Author(s)
      田所 孝広、上野 雄一郎、可児 祐子、関本 俊、大槻 勤
    • Organizer
      2017年原子力学会秋の大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Mo-99/Tc-99m production using an electron linear accelerator2017

    • Author(s)
      Shun Sekimoto, Takahiro Tadokoro, Yuko Kani, Yuichiro Ueno, and Tsutomu Ohtsuki
    • Organizer
      5th International Nuclear Chemistry Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Generator of highly concentrated pure Tc-99m from low specific activity Mo-99 produced by reactor and/or electron linear accelerator2016

    • Author(s)
      K. Tatenuma, A. Tsuguchi, Y. Suzuki, K. Ishikawa, S. Sekimoto, T. Ohtsuki
    • Organizer
      2016 Topical Meeting on Molybdenum-99 Tecnological Development
    • Place of Presentation
      St. Louis, Missouri
    • Year and Date
      2016-09-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 電子線形加速器製造(γ, n)Mo-99 - Tc-99mジェネレータシステム2016

    • Author(s)
      鈴木 祐未、津口 明、皆川 由貴、スパツィアーニ ファビオ、蓼沼 克嘉、関本 俊、大槻 勤
    • Organizer
      日本原子力学会 2016年秋の大会
    • Place of Presentation
      久留米シティプラザ
    • Year and Date
      2016-09-07
    • Related Report
      2016 Research-status Report
  • [Presentation] ライナック製造Mo-99 - Tc-99mアルミナジェネレータ2016

    • Author(s)
      蓼沼 克嘉、鈴木 祐未、津口 明、石川 幸治、田仲 睦、関本 俊、大槻 勤
    • Organizer
      53回 アイソトープ・放射線研究発表会
    • Place of Presentation
      東京大学
    • Year and Date
      2016-07-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Separation and purification of Tc-99m from Mo-99 produced by electron linear accelerator2016

    • Author(s)
      Katsuyoshi Tatenuma, Yumi Suzuki, Akira Tsuguchi, Atsushi Tanaka, Takahiro Tadokoro, Yuko Kani, Yasumasa Morikawa, Asaki Yamamoto, Shun Sekimoto, Tsutomu Ohtsuki
    • Organizer
      1st International Conference on Radiochemical a nd Nuclear Chemistry
    • Place of Presentation
      Budapest
    • Year and Date
      2016-04-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2020-03-30  

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