A novel strategy for radiosensitization using titanium peroxide nanoparticles

• Project/Area Number: 16K15581
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kobe University
• Principal Investigator: SASAKI RYOHEI 神戸大学, 医学部附属病院, 教授 (30346267)
• Co-Investigator(Kenkyū-buntansha): 荻野 千秋 神戸大学, 工学研究科, 教授 (00313693) ; 佐藤 和好 群馬大学, 大学院理工学府, 准教授 (40437299) ; 沼子 千弥 千葉大学, 大学院理学研究院, 准教授 (80284280) ; 中山 雅央 神戸大学, 医学研究科, 医学研究員 (60582004) ; 赤坂 浩亮 神戸大学, 医学部附属病院, 特命助教 (20707161) ; 犬伏 祥子 (カリヤ) 神戸大学, 医学研究科, 特命助教 (60585959)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
• Keywords: Nanoparticle / Radiosensitization / Cancer / ナノ粒子 / 放射線増感 / 膵臓癌

Outline of Final Research Achievements

Polyacrylic acid (PAA)-modified titanium peroxide nanoparticles (PAA-TiOxNPs) are promising radiosensitizers. PAA-TiOxNPs were synthesized from commercial TiO2 nanoparticles that were modified with PAA and functionalized by H2O2treatment. To realize practical clinical uses for PAA-TiOxNPs, their tissue distribution and acute toxicity were evaluated using healthy mice and mice bearing tumors derived from xenografted Mhuman pancreatic cancer cells. Such high accumulation could be associated with enhanced permeability and retention effects of the tumor, as PAA-TiOxNPs are composed of inorganic particles and polymers, without tumor-targeting molecules.

Academic Significance and Societal Importance of the Research Achievements

これまで放射線増感剤は実用化されている化合物はなく、過酸化チタンナノ粒子は難治癌に対する治療戦略の中で極めて有望な候補物質といえる。動物実験では、腫瘍増殖抑制効果が認められた濃度設定において、体重減少などの有害反応は認められていないが、今後前臨床試験や臨床試験への移行するためには、ナノ粒子の均一な製造方法や表面修飾方法を更に検討していく必要があると思われる。

Research Products

• [Journal Article] Predicting the survival of patients with bone metastases treated with radiation therapy: a validation study of the Katagiri scoring system (2019)
  • Author(s): Kubota Hikaru、Soejima Toshinori、Sulaiman Nor Shazrina、Sekii Shuhei、Matsumoto Yoko、Ota Yosuke、Tsujino Kayoko、Fujita Ikuo、Fujimoto Takuya、Morishita Masayuki、Ikegaki Junichi、Matsumoto Koji、Sasaki Ryohei
  • Journal Title: Radiation Oncology Volume: 14(1) Issue: 1 Pages: 13-13
  • DOI: 10.1186/s13014-019-1218-z
  • NAID: 120006552886
  • Peer Reviewed / Open Access
• [Journal Article] In vivo tissue distribution and safety of polyacrylic acid-modified titanium peroxide nanoparticles as novel radiosensitizers (2018)
  • Author(s): Morita Kenta、Suzuki Takahiro、Nishimura Yuya、Matsumoto Kazuhisa、Numako Chiya、Sato Kazuyoshi、Nakayama Masao、Sasaki Ryohei、Ogino Chiaki、Kondo Akihiko
  • Journal Title: Journal of Bioscience and Bioengineering Volume: - Issue: 1 Pages: 30749-30751
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  • NAID: 40021601146
  • Peer Reviewed
• [Journal Article] Gold nanoparticles enhance X?ray irradiation?induced apoptosis in head and neck squamous cell carcinoma in?vitro (2018)
  • Author(s): Teraoka Shun、Kakei Yasumasa、Akashi Masaya、Iwata Eiji、Hasegawa Takumi、Miyawaki Daisuke、Sasaki Ryohei、Komori Takahide
  • Journal Title: Biomedical Reports Volume: 9(5) Pages: 415-420
  • DOI: 10.3892/br.2018.1142
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• [Journal Article] Ionizing radiation enhances paracellular permeability through alteration of intercellular junctions in cultured human lymphatic endothelial cells (2018)
  • Author(s): Megumi Kishimoto, Masaya Akashi, Yasumasa Kakei, Junya Kusumoto, Akiko Sakakibara, Takumi Hasegawa, Shungo Furudoi, Ryohei Sasaki, Takahide Komori
  • Journal Title: Lymphatic Research and Biology Volume: 印刷中 Issue: 4 Pages: 390-396
  • DOI: 10.1089/lrb.2017.0072
  • NAID: 120006543332
  • Peer Reviewed
• [Journal Article] Comparison of dosimetric parameters in the treatment planning of magnetic resonance imaging-based intracavitary image-guided adaptive brachytherapy with and without optimization using the central shielding technique. (2018)
  • Author(s): Nishikawa R, Yoshida K, Ebina Y, Omoteda M, Miyawaki D, Ishihara T, Ejima Y, Akasaka H, Satoh H, Kyotani K, Takahashi S, Sasaki R.
  • Journal Title: Journal of Radiation Research Volume: 印刷中 Issue: 3 Pages: 316-326
  • DOI: 10.1093/jrr/rry009
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Transcutaneous carbon dioxide enhances the antitumor effect of radiotherapy on oral squamous cell carcinoma (2018)
  • Author(s): Iwata Eiji、Hasegawa Takumi、Ueha Takeshi、Takeda Daisuke、Saito Izumi、Kawamoto Teruya、Akisue Toshihiro、Sakai Yoshitada、Sasaki Ryohei、Kuroda Ryosuke、Komori Takahide
  • Journal Title: Oncology Reports Volume: 40(1) Pages: 434-442
  • DOI: 10.3892/or.2018.6444
  • NAID: 120006653254
  • Peer Reviewed
• [Journal Article] Myo-inositol concentration in MR spectroscopy for differentiating high grade glioma from primary central nervous system lymphoma. (2018)
  • Author(s): Nagashima H, Sasayama T, Tanaka K, Kyotani K, Sato N, Maeyama M, Kohta M, Sakata J, Yamamoto Y, Hosoda K, Itoh T, Sasaki R, Kohmura E.
  • Journal Title: J Neurooncol. Volume: 136 Issue: 2 Pages: 317-326
  • DOI: 10.1007/s11060-017-2655-x
  • NAID: 120006769211
  • Peer Reviewed
• [Journal Article] Clinical log data analysis for assessing the accuracy of the CyberKnife fiducial-free lung tumor tracking system (2018)
  • Author(s): Nakayama Masao、Nishimura Hideki、Mayahara Hiroshi、Nakamura Masaki、Uehara Kazuyuki、Tsudou Shinji、Harada Aya、Akasaka Hiroaki、Sasaki Ryohei
  • Journal Title: Practical Radiation Oncology Volume: 8 Issue: 2 Pages: 63-70
  • DOI: 10.1016/j.prro.2017.10.014
  • NAID: 120006873065
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of a Small Animal Irradiation System for Animal Experiments Using EBT3 Model GAFCHROMIC8482 Film (2018)
  • Author(s): Shimizu Y, Akasaka H, Miyawaki D, Mukumoto N, Nakayama M, Wang T, Osuga S, Inubushi S, Yada R, Ejima Y, Yoshida K, Ishihara T, Sasaki R
  • Journal Title: Kobe J Med Sci. Volume: 63(3)
  • Peer Reviewed
• [Journal Article] Investigation of the efficacy and safety of CyberKnife hypofractionated stereotactic radiotherapy for brainstem metastases using a new evaluation criterion: ‘symptomatic control’ (2017)
  • Author(s): Nakamura Masaki、Nishimura Hideki、Mayahara Hiroshi、Uezono Haruka、Harada Aya、Hashimoto Naoki、Ejima Yasuo、Ishihara Takeaki、Nishikawa Ryo、Sasaki Ryohei
  • Journal Title: Journal of Radiation Research Volume: 58 Issue: 6 Pages: 834-839
  • DOI: 10.1093/jrr/rrx042
  • NAID: 120006377648
  • Peer Reviewed / Open Access
• [Journal Article] Impact of alcohol dehydrogenase-aldehyde dehydrogenase polymorphism on clinical outcome in patients with hypopharyngeal cancer (2017)
  • Author(s): Avin?sal Mehmet Ozgur、Shinomiya Hirotaka、Teshima Masanori、Kubo Mie、Otsuki Naoki、Kyota Naomi、Sasaki Ryohei、Zen Yoh、Nibu Ken-ichi
  • Journal Title: Head & Neck Volume: 40 Issue: 4 Pages: 770-777
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  • Peer Reviewed
• [Journal Article] Application of dual-energy CT to suppression of metal artefact caused by pedicle screw fixation in radiotherapy: a feasibility study using original phantom (2017)
  • Author(s): Wang Tianyuan、Ishihara Takeaki、Kono Atsushi、Yoshida Naoki、Akasaka Hiroaki、Mukumoto Naritoshi、Yada Ryuichi、Ejima Yasuo、Yoshida Kenji、Miyawaki Daisuke、Kakutani Kenichiro、Nishida Kotaro、Negi Noriyuki、Minami Toshiaki、Aoyama Yuuichi、Takahashi Satoru、Sasaki Ryohei
  • Journal Title: Physics in Medicine & Biology Volume: 62 Issue: 15 Pages: 6226-6245
  • DOI: 10.1088/1361-6560/aa7d7f
  • Peer Reviewed / Open Access
• [Journal Article] Particle Therapy Using Protons or Carbon Ions for Unresectable or Incompletely Resected Bone and Soft Tissue Sarcomas of the Pelvis, (2017)
  • Author(s): Yusuke Demizu, Dongcun Jin, Nor Shazrina Sulaiman, Fumiko Nagano, Kazuki Terashima, Sunao Tokumaru, Takashi Akagi, Osamu Fujii, Takashi Daimon, Ryohei Sasaki, Nobukazu Fuwa, Tomoaki Okimoto,
  • Journal Title: Int J Radiat Oncol Biol Physc Volume: 98(2) Pages: 367-374
  • Peer Reviewed
• [Journal Article] Relationship between the uptake of 18F-borono-L-phenylalanine and L-[methyl-11C] methionine in head and neck tumors and normal organs (2017)
  • Author(s): Yoshiaki Watanabe, Hiroaki Kurihara, Jun Itami, Ryohei Sasaki, Yasuaki Arai, Kazuro Sugimura
  • Journal Title: Radiat Oncol Volume: 12(1) Issue: 1 Pages: 17-17
  • DOI: 10.1186/s13014-017-0763-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] [18F]Fluorodeoxyglucose uptake by positron emission tomography predicts outcomes for oropharyngeal and hypopharyngeal cancer treated with definitive radiotherapy (2017)
  • Author(s): Takeaki Ishihara, Kazuhiro Kitajima, Yuko Suenaga, Yasuyuki Shimizu, Saki Osuga, Yasuo Ejima, Hirokazu Komatsu, Naoki Otsuki, Kenichi Nibu, Naomi kiyota, Satoru Takahashi, and Ryohei Sasaki,
  • Journal Title: Nagoya Journal of Medical Science Volume: 79 Issue: 1 Pages: 27-36
  • DOI: 10.18999/nagjms.79.1.27
  • NAID: 120005972911
  • ISSN: 2186-3326
  • URL: https://nagoya.repo.nii.ac.jp/records/23422
  • Peer Reviewed
• [Journal Article] Sparing of tissue by using micro-slit-beam radiation therapy reduces neurotoxicity compared with broad-beam radiation therapy. (2017)
  • Author(s): Naritoshi Mukumoto, Masao Nakayama, Hiroaki Akasaka, Yasuyuki Shimizu, Saki Osuga, Daisuke Miyawaki, Kenji Yoshida, Yasuo Ejima, Yasushi Miura, Keiji Umetani, Takeshi Kondoh, Ryohei Sasaki,
  • Journal Title: J Radiat Res Volume: 58(1) Issue: 1 Pages: 17-23
  • DOI: 10.1093/jrr/rrw065
  • NAID: 120006220810
  • Peer Reviewed / Open Access
• [Journal Article] MGDG extracted from spinach enhances the cytotoxicity of radiation in pancreatic cancer cells. (2016)
  • Author(s): Akasaka H, Mizushina Y, Yoshida K, Ejima Y, Mukumoto N, Wang T, Inubushi S, Nakayama M, Wakahara Y, Sasaki R.
  • Journal Title: Radiat Oncol Volume: 11（１） Issue: 1 Pages: 153-153
  • DOI: 10.1186/s13014-016-0729-0
  • NAID: 120005898712
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Dosimetric factors predicting radiation pneumonitis after CyberKnife stereotactic body radiotherapy for peripheral lung cancer. (2016)
  • Author(s): Nakamura M, Nishimura H, Nakayama M, Mayahara H, Uezono H, Harada A, Hashimoto N, Ejima Y, Ishihara T, Sasaki R.
  • Journal Title: Br J Radiol Volume: 89(1068) Issue: 1068 Pages: 20160560-20160560
  • DOI: 10.1259/bjr.20160560
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of titanium dioxide nanoparticles modified with polyacrylic acid and H2O2 for use as a novel Radiosensitizer, (2016)
  • Author(s): Morita K, Miyazaki S, Numaki C, Ikeno S, Sasaki R, Nishimura Y, Ogino C, Kondo A,
  • Journal Title: Free Radical Research, Volume: 50(12) Issue: 12 Pages: 1319-1328
  • DOI: 10.1080/10715762.2016.1241879
  • Peer Reviewed
• [Journal Article] The current status of space modulated radiotherapy. (2016)
  • Author(s): Ryohei Sasaki, Tianyuan Wang, Hiroaki Akasaka, Sachiko Inubushi, Kenji Yoshida, Shohei Komatsu, Yusuke Demizu, Takumi Fukumoto
  • Journal Title: Internal Medicine Review Volume: 2(9) Pages: 1-1
  • Peer Reviewed
• [Journal Article] Prospective Cohort Study of Performance Status and Activities of Daily Living after Surgery for Spinal Metastasis (2016)
  • Author(s): Kakutani K, Sakai Y, Maeno Y, Takada T, Yurube T, Kurakawa T, Miyazaki S, Terashima Y, Ito M, Hara H, Kawamoto T, Ejima Y, Sakashita A, Kizawa Y, Sasaki R, Akisue T, Minami H, Kuroda R, Kurosaka R, Nishida K
  • Journal Title: Clinical Spine Surgery Volume: - Issue: 8 Pages: E1026-E1032
  • DOI: 10.1097/bsd.0000000000000456
  • Peer Reviewed
• [Journal Article] Cause and occurrence timing of osteoradionecrosis of the jaw: a retrospective study focusing on prophylactic tooth extraction, (2016)
  • Author(s): Satoshi Wanifuchi, Masaya Akashi, Yasuo Ejima, Hirotaka Shinomiya, Tsutomu Minamikawa, Shungo Furudoi, Naoki Otsuki, Ryohei Sasaki, Ken-ichi Nibu, Takahide Komori,
  • Journal Title: Oral and Maxillofacial Surgery, Volume: 20(4) Issue: 4 Pages: 337-342
  • DOI: 10.1007/s10006-016-0570-5
  • Peer Reviewed
• [Journal Article] Titanium peroxide nanoparticles enhanced cytotoxic effects of X-ray irradiation against pancreatic cancer model through reactive oxygen species generation in vitro and in vivo (2016)
  • Author(s): Masao Nakayama, Ryohei Sasaki, Chiaki Ogino, Tsutomu Tanaka, Kenta Morita, Mitsuo Umetsu, Satoshi Ohara, Zhenquan Tan, Yuya Nishimura, Hiroaki Akasaka, Kazuyoshi Sato, Chiya Numako, Seiichi Takami, Akihiko Kondo
  • Journal Title: Radiat Oncol. Volume: 11(1) Issue: 1 Pages: 91-91
  • DOI: 10.1186/s13014-016-0666-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Diagnostic value of glutamate with 2-hydroxyglutarate in magnetic resonance spectroscopy for IDH1 mutant glioma (2016)
  • Author(s): Nagashima H, Tanaka K, Sasayama T, Irino Y, Sato N, Takeuchi Y, Kyotani K, Mukasa A, Mizukawa K, Sakata J, Yamamoto Y, Hosoda K, Itoh T, Sasaki R, Kohmura E.
  • Journal Title: Neuro Oncol Volume: 18(11) Pages: 1559-1568
  • DOI: 10.1093/neuonc/now090
  • Peer Reviewed
• [Journal Article] Hypofractionated stereotactic radiotherapy for brain metastases from lung cancer : Evaluation of indications and predictors of local control. (2016)
  • Author(s): Ishihara T, Yamada K, Harada A, Isogai K, Tonosaki Y, Demizu Y, Miyawaki D, Yoshida K, Ejima Y, Sasaki R.
  • Journal Title: Strahlenther Onkol. Volume: 192(6) Issue: 6 Pages: 386-393
  • DOI: 10.1007/s00066-016-0963-2
  • Peer Reviewed
• [Journal Article] Efficacy of Stereotactic Body Radiotherapy for Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis / Inferior Vena Cava Tumor Thrombosis: Evaluation by Comparison with Conventional Three-Dimensional Conformal Radiotherapy, (2016)
  • Author(s): Yoshiro Matsuo, Kenji Yoshida, Hideki, Nishimura, Yasuo Ejima, Daisuke Miyawaki, Haruka Uezono, Takeaki Ishihara, Hiroshi Mayahara, Takumi Fukumoto, Yonson Ku, Masato Yamaguchi, Koji Sugimoto, and Ryohei Sasaki,
  • Journal Title: J Radiat Res Volume: 57(5) Issue: 5 Pages: 512-523
  • DOI: 10.1093/jrr/rrw028
  • Peer Reviewed / Open Access
• [Journal Article] Radiotherapy for brainstem gliomas in children and adults: A single-institution experience and literature review. (2016)
  • Author(s): Yoshida K, Sulaiman NS, Miyawaki D, Ejima Y, Nishimura H, Ishihara T, Matsuo Y, Nishikawa R, Sasayama T, Hayakawa A, Kohmura E, Sasaki R
  • Journal Title: Asia Pac J Clin Oncol. Volume: Mar 3 Issue: 2 Pages: 1-8
  • DOI: 10.1111/ajco.12451
  • NAID: 120006375924
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• [Journal Article] Randomized Trial of Standard Pain Control with or without Gabapentin for Pain Related to Radiation-induced Mucositis in Head and Neck Cancer. (2016)
  • Author(s): Tomoko Kataoka, Naomi Kiyota, Takanobu Shimada, Yohei Funakoshi, Naoko Chayahara, Masanori Toyoda, Yutaka Fujiwara, Kenichi Nibu, Takahide Komori, Ryohei Sasaki, Toru Mukohara, and Hironobu Minami,
  • Journal Title: Auris Nasus Larynx, Volume: 43(6) Issue: 6 Pages: 677-84
  • DOI: 10.1016/j.anl.2016.02.012
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• [Journal Article] A Dosimetric Comparison of Volumetric Modulated Arc Therapy (VMAT) with Unflattened Beams to VMAT with Flattened Beams and TomoTherapy for Head and Neck Cancer (2016)
  • Author(s): Toshiyuki Ogata, Hideki Nishimura, Hiroshi Mayahara, Aya Harada, Yoshiro Matsuo, Masao Nakayama, Kazuyuki Uehara, Shinji Tsudou, Yasuo Ejima, Ryohei Sasaki, Takanobu Okayama
  • Journal Title: Journal of Nuclear Medicine and Radiation Therapy Volume: 7 Issue: 01 Pages: 274-274
  • DOI: 10.4172/2155-9619.1000274
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] FDG-PET/contrast-enhanced CT as a post-treatment tool in head and neck squamous cell carcinoma: comparison with FDG-PET/non-contrast-enhanced CT and contrast-enhanced CT. (2016)
  • Author(s): Suenaga Y, Kitajima K, Ishihara T, Sasaki R, Otsuki N, Nibu KI, Minamikawa T, Kiyota N, Sugimura K.
  • Journal Title: Eur Radiol. Volume: 26(4) Issue: 4 Pages: 1018-1030
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• [Journal Article] [(18)F]-FDG PET/CT imaging for detection of nodal metastases in patients with squamous cell carcinoma of the pharynx and larynx: comparison with CT. (2016)
  • Author(s): Suenaga Y, Kitajima K, Kanda T, Otsuki N, Nibu K, Sasaki R, Itoh T, Sugimura K.
  • Journal Title: Jpn J Radiol. Volume: 34 Issue: 3 Pages: 203-210
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  • NAID: 210000165125
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• [Journal Article] Concomitant chemoradiotherapy for advanced squamous cell carcinoma of temporal bone (2016)
  • Author(s): Shinomiya H, Hasegawa S, Yamashita D, Ejima Y, Kenji Y, Otsuki N, Kiyota N, Sakakibara S, Nomura T, Hashikawa K, Kohmura E, Sasaki R, Nibu KI.
  • Journal Title: Head Neck. Volume: 38 Suppl 1 Issue: S1
  • DOI: 10.1002/hed.24133
  • Peer Reviewed
• [Presentation] 過酸化チタンナノ粒子の併用による放射線増感治療法の開発 (2018)
  • Author(s): 西村 勇哉, 森田 健太, 荻野 千秋, 犬伏 祥子, 佐々木 良平, 近藤 昭彦
  • Organizer: 第34回日本DDS学会
• [Presentation] 放射線治療のための金ナノ粒子内包分子インプリントポリマーナノゲルの開発 (2018)
  • Author(s): 北山 雄己哉, 山田 託也, 木口 健太朗, 吉田 碧衣, 赤坂 浩亮, 西村 勇哉, 五十嵐 一紀, 松本 有, 佐々木 良平, 竹内 俊文
  • Organizer: 第40回日本バイオマテリアル学会
• [Presentation] Bystander effect of exosomes derived from cervical adenocarcinoma cells in response to irradiation (2018)
  • Author(s): Sachiko Inubushi, Yoshiko Fujita, Ryohei Sasaki
  • Organizer: International Society for Extracellular Vesicles 2018
  • Int'l Joint Research
• [Presentation] Effect of exosome of radiation-induced cervical adenocarcinoma (2018)
  • Author(s): Sachiko Inubushi, Yoshiko Fujita, Ryohei Sasaki
  • Organizer: 第10回日本RNAi研究会 第5回日本細胞外小胞学会
• [Presentation] In situステルス性獲得にもとづく長期血中滞留性金ナノ粒子内包分子インプリントナノゲルの創製 (2018)
  • Author(s): 北山 雄己哉, 山田 託也, 赤坂 浩亮, 西村 勇哉, 五十嵐 一紀, 松本 有, 佐々木 良平, 竹内 俊文
  • Organizer: 第40回日本バイオマテリアル学会
• [Presentation] チームで取り組む転移性骨腫瘍ー放射線療法のパラダイムシフトー (2017)
  • Author(s): 佐々木良平
  • Organizer: 第51回大阪脊椎外科フォーラム
  • Invited
• [Presentation] 頭頸部がんに対する放射線治療の個別化：治療効果予測からの検討 (2017)
  • Author(s): 佐々木良平、宮脇大輔、清田尚臣、大月直樹、丹生健一
  • Organizer: 第41回日本頭頸部癌学会
• [Presentation] 73.Assessment of the threshold dose for radiation fibrosis in thoracic esophageal cancer patients. (2016)
  • Author(s): Yasuo Ejima, Kenji Yoshida, Daisuke Miyawaki, Takeaki Ishihara, Ryo Nishikawa, Hiroki Kawaguchi, Yoshiro Matsuo, Atsuki Ikeda, Masanori Toyoda, Tetsu Nakamura, Ryohei Sasaki,
  • Organizer: The 1st Meeting of the Federation of Asisan Organizations for Radiation Oncology (FARO),
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2016-11-25
  • Int'l Joint Research
• [Presentation] Space Modulated Particle Therapy with Newly Invented Bio-absorbable Spacer. (2016)
  • Author(s): Ryohei Sasaki, Hiroaki Akasaka, Sachiko Inubushi, Tianyuan Wang, Yasuyuki Shimizu, Saki Osuga, Yusuke Demizu, Takumi Fukumoto,
  • Organizer: the 4th Taiwan-Japan Radiation Oncology Symposium
  • Place of Presentation: Taipei Taiwan
  • Year and Date: 2016-06-04
  • Int'l Joint Research / Invited
• [Presentation] 76.Assessment of Parametrial Response in stage IIB/IIIB Cervical Cancer Patients from EMBRACE (2016)
  • Author(s): Kenji Yoshida, Ryohei Sasaki
  • Organizer: the 4th Taiwan-Japan Radiation Oncology Symposium
  • Place of Presentation: Taipei Taiwan
  • Year and Date: 2016-06-04
  • Int'l Joint Research
• [Book] Non-woven Fabrics (2016)
  • Author(s): Ryohei Sasaki, Hiroaki Akasaka, Yusuke Demizu, Sachiko Inubushi, Tianyuan Wang, Takumi Fukumoto
  • Total Pages: 324
  • Publisher: Intech
• [Book] Radiotherapy (2016)
  • Author(s): Yasuo Ejima, Takeaki Ishihara, Daisuke Miyawaki, Kenichiro Kakutani, Kotaro Nishida, Junichiro Inoue, Yoshitada Sakai, Tianyuan Wang, Ryohei Sasaki,
  • Publisher: Intech
• [Book] 耳鼻咽喉科・頭頸部外科研修ノート 改訂第2版 (2016)
  • Author(s): 佐々木良平、永井良三（監修）
  • Total Pages: 644
  • Publisher: 診断と治療社