Development of an imaging probe targeting receptor for advanced glycation end-products (RAGE): Challenge to overcoming false-positive results of amyloid PET
| Project/Area Number |
16K15583
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
UEDA Masashi 岡山大学, 医歯薬学総合研究科, 教授 (40381967)
|
|---|
| Research Collaborator |
MATSUURA Yuki
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 放射性医薬品 / 生体分子イメージング / アルツハイマー病 / 最終糖化産物受容体（RAGE） / 分子イメージング / RAGE / ニコチン性アセチルコリン受容体 |
|---|
| Outline of Final Research Achievements |
The present study aimed to develop an imaging probe targeting receptor for advanced glycation end-products (RAGE). A novel radioiodinated probe targeting RAGE was successfully synthesized. Age-related changes in expression level of RAGE and nicotinic acetylcholine receptors (nAChRs) were also examined in a transgenic mouse model of Alzheimer’s disease. The present study revealed an increase in RAGE expression and decrease in alpha4beta2-nAChR expression according to aging. Expression level of alpha7-nAChRs did not change during aging, although it was higher in the transgenic mice compared to wild-type mice.
|
Report
(3 results)
Research Products
(3 results)
