Development of an imaging probe targeting receptor for advanced glycation end-products (RAGE): Challenge to overcoming false-positive results of amyloid PET

• Project/Area Number: 16K15583
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Okayama University
• Principal Investigator: UEDA Masashi 岡山大学, 医歯薬学総合研究科, 教授 (40381967)
• Research Collaborator: MATSUURA Yuki
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 放射性医薬品 / 生体分子イメージング / アルツハイマー病 / 最終糖化産物受容体（RAGE） / 分子イメージング / RAGE / ニコチン性アセチルコリン受容体

Outline of Final Research Achievements

The present study aimed to develop an imaging probe targeting receptor for advanced glycation end-products (RAGE). A novel radioiodinated probe targeting RAGE was successfully synthesized. Age-related changes in expression level of RAGE and nicotinic acetylcholine receptors (nAChRs) were also examined in a transgenic mouse model of Alzheimer’s disease. The present study revealed an increase in RAGE expression and decrease in alpha4beta2-nAChR expression according to aging. Expression level of alpha7-nAChRs did not change during aging, although it was higher in the transgenic mice compared to wild-type mice.

Research Products

• [Presentation] 放射性分子プローブを利用した生体機能分析 (2018)
  • Author(s): 上田 真史
  • Organizer: 日本薬学会第138年会
  • Invited
• [Presentation] アルツハイマー病における認知機能低下の画像バイオマーカーとしてのニコチン／NMDA受容体イメージングの可能性比較 (2016)
  • Author(s): 松浦有希、上田真史、佐野紘平、佐治英郎、榎本秀一
  • Organizer: 第55回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
  • Place of Presentation: 就実大学（岡山県岡山市）
  • Year and Date: 2016-11-05
• [Presentation] アルツハイマー病の認知機能の画像バイオマーカー標的としての脳糖代謝およびニコチン受容体の有用性の解明 (2016)
  • Author(s): 松浦有希、上田真史、檜垣佑輔、佐野紘平、佐治英郎、榎本秀一
  • Organizer: 第56回日本核医学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2016-11-03