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A non-invasive tool for detecting pancreatic tumor-bearing murine odor by C. elegans

Research Project

Project/Area Number 16K15591
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionOsaka University

Principal Investigator

KAWAMOTO Koichi  大阪大学, 医学系研究科, 特任助教(常勤) (30432470)

Co-Investigator(Kenkyū-buntansha) 江口 英利  大阪大学, 医学系研究科, 准教授 (90542118)
西田 尚弘  大阪大学, 医学系研究科, 助教 (50588118)
今野 雅允  大阪大学, 医学系研究科, 寄附講座講師 (80618207)
小関 準  大阪大学, 医学系研究科, 特任助教(常勤) (20616669)
石井 秀始  大阪大学, 医学系研究科, 特任教授(常勤) (10280736)
Co-Investigator(Renkei-kenkyūsha) MORI Masaki  大阪大学, 大学院医学系研究科, 教授 (70190999)
HIROTSU Takaaki  九州大学, 大学院理学研究科, 助教 (70404035)
SUGIMOTO Masahiro  慶応義塾大学, 政策メディア研究科, 特任准教授 (30458963)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords膵癌 / 早期診断 / 綿虫 / 嗅覚レセプター / スクリーニング / 線虫 / 聴覚レセプター
Outline of Final Research Achievements

Diagnosis of pancreatic ductal adenocarcinoma is associated with dismal prognosis despite current best therapies, including surgery, chemoradiation, and immunotherapy. Previous studies reported that wild-type C. Elegans displayed attractive chemotaxis towards human urine from cancer patients but avoided control urine from healthy volunteers. In this study, our research group demonstrated that C. Elegans induces chemotactic properties to the urine from pancreatic tumor-bearing mice. Furthermore, urine from c-Met knockout has minimal effect to these chemotactic properties. These results suggest that urine from tumor-bearing mice could provide a new strategy to detect and study disease-associated scents in the future.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (11 results)

All 2018 2017 2016

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 9 results) Presentation (2 results)

  • [Journal Article] Enzymes of the one-carbon folate metabolism as anticancer targets predicted by survival rate analysis2018

    • Author(s)
      Koseki Jun、Konno Masamitsu、Asai Ayumu、Colvin Hugh、Kawamoto Koichi、Nishida Naohiro、Sakai Daisuke、Kudo Toshihiro、Satoh Taroh、Doki Yuichiro、Mori Masaki、Ishii Hideshi
    • Journal Title

      Sci. Rep.

      Volume: 8 Issue: 1 Pages: 303-303

    • DOI

      10.1038/s41598-017-18456-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Computational trans-omics approach characterised methylomic and transcriptomic involvements and identified novel therapeutic targets for chemoresistance in gastrointestinal cancer stem cells2018

    • Author(s)
      Konno Masamitsu、Matsui Hidetoshi、Koseki Jun、Asai Ayumu、Kano Yoshihiro、Kawamoto Koichi、Nishida Naohiro、Sakai Daisuke、Kudo Toshihiro、Satoh Taroh、Doki Yuichiro、Mori Masaki、Ishii Hideshi
    • Journal Title

      Sci. Rep.

      Volume: 8 Issue: 1 Pages: 899-899

    • DOI

      10.1038/s41598-018-19284-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The one-carbon metabolism pathway highlights therapeutic targets for gastrointestinal cancer (Review)2017

    • Author(s)
      Konno Masamitsu、Asai Ayumu、Kawamoto Koichi、Nishida Naohiro、Satoh Taroh、Doki Yuichiro、Mori Masaki、Ishii Hideshi
    • Journal Title

      Int. J. Oncol.

      Volume: 50 Issue: 4 Pages: 1057-1063

    • DOI

      10.3892/ijo.2017.3885

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Micro-RNA-130a-3p Regulates Gemcitabine?Resistance via PPARG in Cholangiocarcinoma2017

    • Author(s)
      Asukai Kei、Kawamoto Koichi、Eguchi Hidetoshi、Konno Masamitsu、Asai Ayumu、Iwagami Yoshifumi、Yamada Daisaku、Asaoka Tadafumi、Noda Takehiro、Wada Hiroshi、Gotoh Kunihito、Nishida Naohiro、Satoh Taroh、Doki Yuichiro、Mori Masaki、Ishii Hideshi
    • Journal Title

      Ann. Surg. Oncol.

      Volume: 24 Issue: 8 Pages: 2344-2352

    • DOI

      10.1245/s10434-017-5871-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypoxia stimulates the cytoplasmic localization of oncogenic long noncoding RNA LINC00152 in colorectal cancer2017

    • Author(s)
      Nishizawa Yujiro、Konno Masamitsu、Asai Ayumu、Koseki Jun、Kawamoto Koichi、Miyoshi Norikatsu、Takahashi Hidekazu、Nishida Naohiro、Haraguchi Naotsugu、Sakai Daisuke、Kudo Toshihiro、Hata Taishi、Matsuda Chu、Mizushima Tsunekazu、Satoh Taroh、Doki Yuichiro、Mori Masaki、Ishii Hideshi
    • Journal Title

      Int. J. Oncol.

      Volume: 52 Pages: 453-460

    • DOI

      10.3892/ijo.2017.4218

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer2017

    • Author(s)
      Nishizawa Yujiro、Konno Masamitsu、Asai Ayumu、Koseki Jun、Kawamoto Koichi、Miyoshi Norikatsu、Takahashi Hidekazu、Nishida Naohiro、Haraguchi Naotsugu、Sakai Daisuke、Kudo Toshihiro、Hata Taishi、Matsuda Chu、Mizushima Tsunekazu、Satoh Taroh、Doki Yuichiro、Mori Masaki、Ishii Hideshi
    • Journal Title

      Oncotarget.

      Volume: 9 Issue: 7 Pages: 7476-7486

    • DOI

      10.18632/oncotarget.23554

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitochondrial pyruvate carrier modulates the epithelial-mesenchymal transition in cholangiocarcinoma2017

    • Author(s)
      Ohashi Tomofumi、Eguchi Hidetoshi、Kawamoto Koichi、Konno Masamitsu、Asai Ayumu、Colvin Hugh、Ueda Yuji、Takaoka Hirofumi、Iwagami Yoshifumi、Yamada Daisaku、Asaoka Tadafumi、Noda Takehiro、Wada Hiroshi、Gotoh Kunihito、Kobayashi Shogo、Koseki Jun、Satoh Taroh、Ogawa Kazuhiko、Doki Yuichiro、Mori Masaki、Ishii Hideshi
    • Journal Title

      Oncol. Rep.

      Volume: 39 Pages: 1276-1282

    • DOI

      10.3892/or.2017.6172

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolic adaptation to nutritional stress in human colorectal cancer.2016

    • Author(s)
      Miyo, M., Konno, M., Nishida, N. Sueda, T., Noguchi, K., Matsui, H., Colvin, H., Kawamoto, K., Koseki, J., Haraguchi, N., Nishimura, J., Hata, T., Gotoh, N., Mastuda, F., Saatoh, T., Mizushima, T., Shimizu, H., Doki, Y., Mori, M., Ishii, H.
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 38415-38415

    • DOI

      10.1038/srep38415

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oncometabolite D-2-hydroxyglurate directly induces epithelial-mesenchymal transition and is associated with distant metastasis in colorectal cancer.2016

    • Author(s)
      Colvin, S. H., Nishida, N., Konno, M., Haraguchi, N., Takahashi, H., Nishimura, J., Hata, T., Kawamoto, K. Asai, A., Tsunekuni, K., Koseki, J., Mizushima, T., Satoh, T., Doki, Y., Mori, M., Ishii, H.
    • Journal Title

      Sci. Rep

      Volume: 6 Issue: 1 Pages: 36289-36289

    • DOI

      10.1038/srep36289

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 胆管がん微少環境下における炎症性サイトカイン発現の臨床的意義に関する検討2017

    • Author(s)
      川本弘一、江口英利、飛鳥井慶、今野雅允、西田尚弘、小関準、浅井歩、岩上佳史、山田大作、浅岡忠史、野田剛広、和田浩志、後藤邦仁、佐藤太郎、土岐祐一郎、森正樹、石井秀始
    • Organizer
      第26回日本がん転移学会学術集会・総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 長鎖ノンコーディングRNAの大腸癌におけるエピゲノム制御2017

    • Author(s)
      西田尚弘、Jana Ferdin、今野雅允、小関準、川本弘一、 浅井歩、George Calin、土岐祐一郎、森正樹、石井秀始
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2019-03-29  

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