Research Project
Grant-in-Aid for Challenging Exploratory Research
Comprehensive gene expression analysis was performed on human umbilical cord-derived vascular endothelial cells and human bone marrow mesenchymal cells at the single cell level. Gene expression data on vascular endothelial cells and mesenchymal cells in the iPSC- liver bud was also obtained. Genes expressed in each cell population were analyzed. Furthermore, it was revealed that genes involved in cell-cell interaction in iPSC liver bud. We also analyzed heterogeneity in each cell population. These findings are useful information for quality evaluation in the process of manufacturing human iPSC- liver bud, and for future improvement of iPSC- liver bud quality and safety.
All 2018 2017 2016 Other
All Int'l Joint Research (4 results) Journal Article (6 results) (of which Int'l Joint Research: 5 results, Peer Reviewed: 6 results, Open Access: 5 results) Presentation (12 results) (of which Int'l Joint Research: 1 results, Invited: 1 results) Book (1 results)
Cell Reports
Volume: 6 Issue: 6 Pages: 1620-1629
10.1016/j.celrep.2018.03.123
Stem Cell Reports
Volume: 10 Issue: 3 Pages: 780-793
10.1016/j.stemcr.2018.01.006
Nature
Volume: 546 Issue: 7659 Pages: 533-534
10.1038/nature22796
Scientific Reports
Volume: 8 Issue: 1 Pages: 45751-45751
10.1038/srep45751
Methods Mol Biol
Volume: 1597 Pages: 207-216
10.1007/978-1-4939-6949-4_15
Development
Volume: 144(6) Pages: 1018-1024
10.1242/dev.143032
