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Induction of tumor infiltrating immune cells through regulation of tumor microenvironment and its application for novel cancer immunotherapy

Research Project

Project/Area Number 16K15601
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionKanagawa Cancer Center Research Institute

Principal Investigator

Sasada Tetsuro  地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), がんワクチンセンター, 部長 (70293967)

Co-Investigator(Kenkyū-buntansha) 大竹 淳矢  地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 技師・研究員 (10758915)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords腫瘍浸潤免疫細胞 / ケモカイン / サイトカイン / 異所性リンパ様組織 / がん免疫療法
Outline of Final Research Achievements

The aim of this study was to develop the method to efficiently induce infiltration of immune cells and formation of ectopic lymphoid structures within tumor tissues through artificial modulation of tumor microenvironment. This study examined the effects of chemokines, CCL21 and CXCL13, on tumor growth and immune cell infiltration in murine tumor models. The murine tumor cell lines transfected with CCL21 or CXCL13 showed retardation of tumor growth when implanted into mice, resulting in prolongation of survival of tumor-bearing mice. In addition, they induced infiltration of T cells and B cells within tumor tissues, but did not develop ectopic lymphoid structures. We will further investigate the effects of other chemokines and cytokines on tumor growth and immune cell infiltration and identify the methods to artificially develop ectopic lymphoid structures within tumor tissues.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (25 results)

All 2017 2016

All Journal Article (16 results) (of which Peer Reviewed: 13 results,  Open Access: 11 results) Presentation (9 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Use of patient-derived xenograft mouse models in cancer research and treatment.2017

    • Author(s)
      Yada E, Wada S, Yoshida S, Sasada T.
    • Journal Title

      Future Sci OA.

      Volume: 4 Issue: 3

    • DOI

      10.4155/fsoa-2017-0136

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between PD-L1 expression combined with tumor-infiltrating lymphocytes and the prognosis of patients with advanced hypopharyngeal squamous cell carcinoma.2017

    • Author(s)
      Ono T, Azuma K, Kawahara A, Sasada T, Hattori S, Sato F, Shin B, Chitose SI, Akiba J, Hirohito U.
    • Journal Title

      Oncotarget.

      Volume: 8 Issue: 54 Pages: 92699-92714

    • DOI

      10.18632/oncotarget.21564

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Personalized peptide vaccination as second-line treatment for metastatic upper tract urothelial carcinoma.2017

    • Author(s)
      Suekane S, Ueda K, Nishihara K, Sasada T, Yamashita T, Koga N, Yutani S, Shichijo S, Itoh K, Igawa T, Noguchi M.
    • Journal Title

      Cancer Sci.

      Volume: 108 Issue: 12 Pages: 2430-2437

    • DOI

      10.1111/cas.13404

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Are peptide vaccines viable in combination with other cancer immunotherapies?2017

    • Author(s)
      Ohtake J, Sasada T.
    • Journal Title

      Future Oncol.

      Volume: 13 Issue: 18 Pages: 1577-1580

    • DOI

      10.2217/fon-2017-0136

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Programmed cell death-ligand 1 expression and immunoscore in stage II and III non-small cell lung cancer patients receiving adjuvant chemotherapy.2017

    • Author(s)
      Ishii H, Azuma K, Kawahara A, Matsuo N, Tokito T, Kinoshita T, Yamada K, Sasada T, Akiba J, Hoshino T.
    • Journal Title

      Oncotarget.

      Volume: 8 Issue: 37 Pages: 61618-61625

    • DOI

      10.18632/oncotarget.18651

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Feasibility study of personalized peptide vaccination for hepatocellular carcinoma patients refractory to locoregional therapies2017

    • Author(s)
      Yutani Shigeru、Shirahama Takahisa、Muroya Daisuke、Matsueda Satoko、Yamaguchi Rin、Morita Michi、Shichijo Shigeki、Yamada Akira、Sasada Tetsuro、Itoh Kyogo
    • Journal Title

      Cancer Science

      Volume: 108 Issue: 9 Pages: 1732-1738

    • DOI

      10.1111/cas.13301

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ネオアンチゲンを標的とした免疫療法2017

    • Author(s)
      笹田哲朗
    • Journal Title

      医学のあゆみ がん免疫療法の躍進

      Volume: 263 (1) Pages: 13-19

    • Related Report
      2017 Annual Research Report
  • [Journal Article] A randomized phase II trial of personalized peptide vaccine with low dose cyclophosphamide in biliary tract cancer.2017

    • Author(s)
      Shirahama T, Muroya D, Matsueda S, Yamada A, Shichijo S, Naito M, Yamashita T, Sakamoto S, Okuda K, Itoh K, Sasada T, Yutani S.
    • Journal Title

      Cancer Sci.

      Volume: 印刷中 Issue: 5 Pages: 838-845

    • DOI

      10.1111/cas.13193

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunological evaluation of peptide vaccination for cancer patients with the HLA -A11+ or -A33+ allele.2017

    • Author(s)
      Sakamoto S, Matsueda S, Takamori S, Toh U, Noguchi M, Yutani S, Yamada A, Shichijo S, Yamada T, Suekane S, Kawano K, Naitou M, Sasada T, Hattori N, Kohno N, Itoh K.
    • Journal Title

      Cancer Sci.

      Volume: 印刷中 Issue: 4 Pages: 598-603

    • DOI

      10.1111/cas.13189

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Feasibility Study of Personalized Peptide Vaccination for Advanced Small Cell Lung Cancer.2017

    • Author(s)
      Sakamoto S, Yamada T, Terazaki Y, Yoshiyama K, Sugawara S, Takamori S, Matsueda S, Shichijo S, Yamada A, Noguchi M, Itoh K, Hattori N, Kohno N, Sasada T.
    • Journal Title

      Clin Lung Cancer.

      Volume: 印刷中 Issue: 6 Pages: e385-e394

    • DOI

      10.1016/j.cllc.2017.03.011

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhancement of humoral and cell mediated immune response to HPV16 L1-derived peptides subsequent to vaccination with prophylactic bivalent HPV L1 virus-like particle vaccine in healthy females.2017

    • Author(s)
      Yokomine M, Matsueda S, Kawano K, Sasada T, Fukui A, Yamashita T, Komatsu N, Shichijo S, Tasaki K, Matsukuma K, Itoh K, Kamura T, Ushijima K.
    • Journal Title

      Exp Ther Med.

      Volume: 13 Issue: 4 Pages: 1500-1505

    • DOI

      10.3892/etm.2017.4150

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 遺伝子変異新規抗原(ネオアンチゲン)を標的としたがん免疫療法2017

    • Author(s)
      笹田哲朗
    • Journal Title

      日本臨床(特集)がん免疫療法

      Volume: 75 (2) Pages: 189-195

    • Related Report
      2016 Research-status Report
  • [Journal Article] Current status and future prospects of peptide-based cancer vaccines.2016

    • Author(s)
      Wada S, Yada E, Ohtake J, Fujimoto Y, Uchiyama H, Yoshida S, Sasada T.
    • Journal Title

      Immunotherapy.

      Volume: 8 Issue: 11 Pages: 1321-1333

    • DOI

      10.2217/imt-2016-0063

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immune Responses to Epidermal Growth Factor Receptor (EGFR) and Their Application for Cancer Treatment.2016

    • Author(s)
      Sasada T, Azuma K, Ohtake J, Fujimoto Y.
    • Journal Title

      Front Pharmacol.

      Volume: 7 Pages: 405-405

    • DOI

      10.3389/fphar.2016.00405

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Randomized Phase II Study of Docetaxel plus Personalized Peptide Vaccination versus Docetaxel plus Placebo for Patients with Previously Treated Advanced Wild Type EGFR Non-Small-Cell Lung Cancer.2016

    • Author(s)
      Takayama K, Sugawara S, Saijo Y, Maemondo M, Sato A, Takamori S, Harada T, Sasada T, Kakuma T, Kishimoto J, Yamada A, Noguchi M, Itoh K, Nakanishi Y.
    • Journal Title

      J Immunol Res.

      Volume: 2016 Pages: 1745108-1745108

    • DOI

      10.1155/2016/1745108

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] がんワクチン療法の進歩2016

    • Author(s)
      笹田哲朗
    • Journal Title

      Pharma Media (特集)がん免疫療法ー最近の進歩と展望

      Volume: 34 (10) Pages: 17-22

    • Related Report
      2016 Research-status Report
  • [Presentation] Comprehensive analysis of T cells responsive to neoantigens derived from tumor-specific genetic mutations2017

    • Author(s)
      Tetsuro Sasada, Junya Ohtake, Satoshi Wada, Erika Yada, Shintaro Yoshida
    • Organizer
      AACR Annual Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 大腸がんにおける免疫細胞の形質・機能の解析と免疫抑制機構の解明2017

    • Author(s)
      大竹淳矢、里吉哲太、和田聡、矢田英理香、三神裕美、吉田慎太郎、塩沢学、笹田哲朗
    • Organizer
      第21回日本がん免疫学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Elucidation of potential immune suppressive mechanisms in colorectal cancer2017

    • Author(s)
      Junya Ohtake, Tetsuta Satoyoshi, Satoshi Wada, Erika Yada, Hiromi Mikami, Shintaro Yoshida, Manabu Shiozawa, Tetsuro Sasada
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Comprehensive analysis of immunological tumor environment in colorectal cancer2017

    • Author(s)
      Junya Ohtake, Tetsuta Satoyoshi, Keisuke Kazama, Satoshi Wada, Erika Yada, Hiromi Mikami, Shintaro Yoshida, Manabu Shiozawa, Tetsuro Sasada
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] High immunogenicity of neoantigens derived from tumor-specific gene mutations.2016

    • Author(s)
      Junya Ohtake, Satoshi Wada, Erica Yada, Yuki Fujimoto, Hidemi Uchiyama, Shintaro Yoshida, Tetsuro Sasada.
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄県宜野湾市
    • Year and Date
      2016-12-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Establishment of pancreatic patient-derived xenograft (PDX).2016

    • Author(s)
      Erica Yada, Junya Ohtake, Tetsuro Sasada, Satoshi Wada.
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report
  • [Presentation] Comprehensive analysis of T cell responses specific to neoantigens derived from gene mutations.2016

    • Author(s)
      Junya Ohtake, Satoshi Wada, Erica Yada, Yuki Fujimoto, Hidemi Uchiyama, Shintaro Yoshida, Tetsuro Sasada.
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 突然変異遺伝子に対する特異的T細胞反応の網羅的解析2016

    • Author(s)
      大竹淳矢、和田聡、矢田英理香、藤本佑希、内山秀美、吉田慎太郎、笹田哲朗
    • Organizer
      第20回日本がん免疫学会総会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2016-07-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 膵臓がんゼノグラフトの有用性の検証 ~治療の新規標的分子の探索に向けて~2016

    • Author(s)
      矢田英理香、大竹淳矢、吉田慎太郎、藤本佑希、内山秀美、笹田哲朗、和田聡
    • Organizer
      第20回日本がん免疫学会総会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2016-07-28
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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