Development of new therapy for enhancing liver regeneration by WFA-M2BP, which is a new biomarker for liver fibrosis.

• Project/Area Number: 16K15606
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Gunma University
• Principal Investigator: Shirabe Ken 群馬大学, 大学院医学系研究科, 教授 (70264025)
• Co-Investigator(Kenkyū-buntansha): 内山 秀昭 九州大学, 医学研究院, 共同研究員 (70380425) ; 吉住 朋晴 九州大学, 医学研究院, 准教授 (80363373) ; 池上 徹 九州大学, 大学病院, 講師 (80432938)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2018: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2017: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 肝再生 / WFA-M2BP / 肝再生因子 / 肝星細胞 / 肝Kupffer細胞 / M2BPGi / Kupffer細胞 / 肝細胞 / 肝硬変

Outline of Final Research Achievements

In this study, new mechanism of liver rengenration, based on relationship between hepatic stellate cells and Kuppfer cells has been shown. Furthermore, a new serum factor, which stimulates hepatocyte proliferation.

Academic Significance and Societal Importance of the Research Achievements

本研究から、肝再生の新たな分子機序が明らかになった。また、新たな肝再生因子が明らかになったことで、この再生因子を用いた新たな肝再生促進療法の可能性が開かれた。すなわち、生体部分肝移植における過小グラフトの問題や拡大肝切除に対する再生促進といった臨床上の課題を解決できる可能性がある。

Research Products

• [Journal Article] Response to the letter by Dr. Naoya Yamada, and Dr. Koichi Mizuta regarding our manuscript: "Mac-2 binding protein glycan isomer (M2BPGi) is a new serum biomarker for assessing liver fibrosis: more than a biomarker of liver fibrosis". (2019)
  • Author(s): Shirabe K, Bekki Y, Gantumur D, Araki K, Ishii N, Kuno A, Narimatsu H, Mizokami M.
  • Journal Title: J Gastroenterol Volume: 54 Issue: 2 Pages: 206-7
  • DOI: 10.1007/s00535-018-1524-5
  • Peer Reviewed / Open Access
• [Journal Article] Mac-2 binding protein glycan isomer (M2BPGi) is a new serum biomarker for assessing liver fibrosis: more than a biomarker of liver fibrosis. (2018)
  • Author(s): Shirabe K, Bekki Y, Gantumur D, Araki K, Ishii N, Kuno A, Narimatsu H, Mizokami M.
  • Journal Title: J Gastroenterol. Volume: 53 Issue: 7 Pages: 819-826
  • DOI: 10.1007/s00535-017-1425-z
  • Peer Reviewed / Open Access
• [Presentation] 肝星細胞の新しいバイオマーカーWFA-M2BPの肝臓外科における意義と展望 (2016)
  • Author(s): 調 憲、別城悠樹、戸島剛男、伊藤心二、池上 徹、吉住朋晴、溝上雅史、考藤達哉、間野洋平、久野 敦、成松 久、前原喜彦
  • Organizer: 第116回日本外科学会定期学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2016-04-14