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Development of platform for cancer epigenetic therapy by region-specific inhibition of epigenomic alteration

Research Project

Project/Area Number 16K15608
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionChiba University

Principal Investigator

Kaneda Atsushi  千葉大学, 大学院医学研究院, 教授 (10313024)

Research Collaborator NEMOTO Tetsuhiro  千葉大学, 大学院薬学研究院, 教授 (80361450)
SHINOHARA Ken-ichi  千葉大学, 大学院医学研究院, 助教 (70378561)
SUZUKI Takayoshi  京都府立医科大学, 医学系研究科, 教授 (90372838)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords癌 / エピゲノム
Outline of Final Research Achievements

Epigenomic alteration play important roles in tumorigenesis. Epigenetic inhibitors developed so far, however, reprogram the epigenome broadly and randomly; thus, unfavorable side effects can occur along with the antitumor effects, resulting in limited clinical application. To develop epigenetic inhibitors that could alter epigenetic status in region-selective manner, we here applied the technologies of DNA-binding small molecules that recognized specific DNA sequences. We conjugated epigenetic inhibotor with different small molecules, and successfully altered histone modification at different genomic regions where the specific DNA sequences recognized by the conjugated DNA-binding small molecules were frequently included.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (16 results)

All 2018 2017 2016 Other

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Int'l Joint Research: 3 results,  Invited: 6 results) Book (1 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Synthesis of Pyrrole-Imidazole Polyamide Oligomers Based on a Copper-Catalyzed Cross-Coupling Strategy.2017

    • Author(s)
      Shiga N, Takayanagi S, Muramoto R, Murakami T, Qin R, Suzuki Y, Shinohara K, Kaneda A, Nemoto T.
    • Journal Title

      Bioorg Med Chem Lett,

      Volume: 27 Issue: 10 Pages: 2197-2200

    • DOI

      10.1016/j.bmcl.2017.03.052

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] ゲノム領域選択的なエピゲノム制御アプローチ2017

    • Author(s)
      篠原憲一、金田篤志
    • Journal Title

      Medical Science Digest

      Volume: 43 Pages: 72-75

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
  • [Journal Article] Inhibition of DNA methylation at the MLH1 promoter region using pyrrole-imidazole polyamide.2016

    • Author(s)
      Shinohara K, Yoda N, Takane K, Watanabe T, Fukuyo M, Fujiwara K, Kita K, Nagase H, Nemoto T, Kaneda A.
    • Journal Title

      ACS Omega

      Volume: 1 Issue: 6 Pages: 1164-1172

    • DOI

      10.1021/acsomega.6b00229

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Cancer epigenetics as a target of diagnosis and treatment.2018

    • Author(s)
      Kaneda A.
    • Organizer
      JSMO / ASCO Young Oncologist Workshop 2018.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Epigenetic driver of tumorigenesis in gastrointestinal cancer2017

    • Author(s)
      Atsushi Kaneda, Keisuke Matsusaka, Eiji Sakai, Kenichi Shinohara, Natsumi Yoda, Hiroki Nagase, Tetsuhiro Nemoto, Kokiladevi Alagarswamy, Takayoshi Suzuki, Masaki Fukuyo, Atsushi Okabe, Kiyoko Takane, Sayaka Funata, Hiroe Namba
    • Organizer
      International symposium for the drug-discovery of the pyrrole-imidazole polyamides as novel biomedicines
    • Place of Presentation
      日本大学桜門会館(東京都・東京)
    • Year and Date
      2017-02-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 胃癌で誘導されるエピゲノム異常と小分子を用いた領域特異的エピゲノム制御.2017

    • Author(s)
      金田篤志.
    • Organizer
      千里ライフサイエンスセミナーL1がんシリーズ第6回「エピゲノム情報に基づくがんの制御」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Cancer epigenome and its application to diagnosis and therapy2017

    • Author(s)
      金田篤志
    • Organizer
      第76回日本癌学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Epigenomic alterations contributing to gastrointestinal carcinogenesis and development of small molecules to modify epigenome in region-specific manner2017

    • Author(s)
      金田篤志
    • Organizer
      第40回日本分子生物学会・第90回日本生化学会大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Region specific alteration of histone modification using LSD1 inhibitor conjugated with Pyrrole Imidazole Polyamide.2017

    • Author(s)
      Kokiladevi Alagarswamy, Ken-ichi Shinohara, Atsushi Okabe, Masaki Fukuyo, Natsumi Yoda, Hiroki Nagase, Takayoshi Suzuki, Tetsuhiro Nemoto, Atsushi Kaneda.
    • Organizer
      76th Annual Meeting of the Japanese Cancer Association,
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DNA配列を認識する小分子による選択的 DNAメチル化阻害.2017

    • Author(s)
      篠原憲一、依田夏美、福世真樹、喜多和子、根本哲宏、金田篤志.
    • Organizer
      2017年度生命科学系学会合同年次大会、
    • Related Report
      2017 Annual Research Report
  • [Presentation] がんの層別化とゲノム情報2016

    • Author(s)
      金田篤志
    • Organizer
      千葉県におけるゲノム医療実現に向けて
    • Place of Presentation
      ホテルグリーンタワー幕張(千葉県・千葉市)
    • Year and Date
      2016-10-04
    • Related Report
      2016 Research-status Report
    • Invited
  • [Book] がんゲノムとは2017

    • Author(s)
      金田篤志
    • Publisher
      アルファ・クラブ
    • Related Report
      2016 Research-status Report
  • [Remarks] 分子腫瘍学HP - 千葉大学大学院医学研究院・医学部

    • URL

      http://www.m.chiba-u.ac.jp/class/moloncol/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 千葉大学大学院医学研究院分子腫瘍学

    • URL

      http://www.m.chiba-u.ac.jp/class/moloncol/index.html

    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] 配列特異的で設計可能な標的遺伝子の転写抑制阻害剤およびこれを含む組成物並びにその使用2017

    • Inventor(s)
      金田篤志、篠原憲一、根本哲宏
    • Industrial Property Rights Holder
      金田篤志、篠原憲一、根本哲宏
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017-02-01
    • Related Report
      2016 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] 含窒素芳香族アミドの製造方法、ピロール・イミダゾールポリアミドの製造方法、及び化合物2016

    • Inventor(s)
      根本哲宏、滋賀直樹、高柳志穂里、鈴木雄太、金田篤志
    • Industrial Property Rights Holder
      根本哲宏、滋賀直樹、高柳志穂里、鈴木雄太、金田篤志
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-074677
    • Filing Date
      2016-04-01
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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