Development of platform for cancer epigenetic therapy by region-specific inhibition of epigenomic alteration
| Project/Area Number |
16K15608
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
Kaneda Atsushi 千葉大学, 大学院医学研究院, 教授 (10313024)
|
|---|
| Research Collaborator |
NEMOTO Tetsuhiro 千葉大学, 大学院薬学研究院, 教授 (80361450)
SHINOHARA Ken-ichi 千葉大学, 大学院医学研究院, 助教 (70378561)
SUZUKI Takayoshi 京都府立医科大学, 医学系研究科, 教授 (90372838)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 癌 / エピゲノム |
|---|
| Outline of Final Research Achievements |
Epigenomic alteration play important roles in tumorigenesis. Epigenetic inhibitors developed so far, however, reprogram the epigenome broadly and randomly; thus, unfavorable side effects can occur along with the antitumor effects, resulting in limited clinical application. To develop epigenetic inhibitors that could alter epigenetic status in region-selective manner, we here applied the technologies of DNA-binding small molecules that recognized specific DNA sequences. We conjugated epigenetic inhibotor with different small molecules, and successfully altered histone modification at different genomic regions where the specific DNA sequences recognized by the conjugated DNA-binding small molecules were frequently included.
|
Report
(3 results)
Research Products
(16 results)
-
-
-
-
-
[Presentation] Epigenetic driver of tumorigenesis in gastrointestinal cancer2017
Author(s)
Atsushi Kaneda, Keisuke Matsusaka, Eiji Sakai, Kenichi Shinohara, Natsumi Yoda, Hiroki Nagase, Tetsuhiro Nemoto, Kokiladevi Alagarswamy, Takayoshi Suzuki, Masaki Fukuyo, Atsushi Okabe, Kiyoko Takane, Sayaka Funata, Hiroe Namba
Organizer
International symposium for the drug-discovery of the pyrrole-imidazole polyamides as novel biomedicines
Place of Presentation
日本大学桜門会館（東京都・東京）
Year and Date
2017-02-24
Related Report
Int'l Joint Research / Invited
-
-
-
-
-
-
[Presentation] がんの層別化とゲノム情報2016
Author(s)
金田篤志
Organizer
千葉県におけるゲノム医療実現に向けて
Place of Presentation
ホテルグリーンタワー幕張（千葉県・千葉市）
Year and Date
2016-10-04
Related Report
Invited
-
-
-
-
-
