Research Project
Grant-in-Aid for Challenging Exploratory Research
It was very difficult in the past to screen inhibitors of JARID1B, one of epigenome regulatory factor. We have made it possible using our in silico screening technologies with large-scale computer. In silico screening has been already performed to pick up the candidate compounds from five million drug like compounds. Then, we selected first lead compounds from the picked up candidate compounds with chemical assay. We have investigated the in vitro anti-cancer effects of these lead compounds, and the after, investigated the in vivo anti-cancer effects for the part of them. We succeeded in establishing a pathway to show the synthetic evolution guidelines for lead compounds based on the functional information from these experimental results. According to this procedure, it is possible to design a more efficient drug structure.
All 2018 2017 2016
All Journal Article (14 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 14 results, Open Access: 12 results, Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 3 results, Invited: 1 results)
Sci. Rep.
Volume: 8 Issue: 1 Pages: 303-303
10.1038/s41598-017-18456-x
Volume: 8 Issue: 1 Pages: 899-899
10.1038/s41598-018-19284-3
Oncotarget.
Volume: 8 Issue: 32 Pages: 53017-53027
10.18632/oncotarget.18078
Oncol. Lett.
Volume: 14 Issue: 4 Pages: 4483-4490
10.3892/ol.2017.6817
Int. J. Oncol.
Volume: 52 Pages: 621-629
10.3892/ijo.2017.4219
Volume: 52 Pages: 453-460
10.3892/ijo.2017.4218
Volume: 9 Issue: 7 Pages: 7476-7486
10.18632/oncotarget.23554
Oncol. Rep.
Volume: 39 Pages: 1276-1282
10.3892/or.2017.6172
Ann. Surg. Oncol.
Volume: 24 Issue: 3 Pages: 841-849
10.1245/s10434-016-5395-9
Volume: 37 Issue: 1 Pages: 417-425
10.3892/or.2016.5264
Mol. Clinic. Oncol.
Volume: 6 Issue: 1 Pages: 130-137
10.3892/mco.2016.1088
Chemical and Pharmaceutical Bulletin
Volume: 64 Issue: 7 Pages: 1031-1035
10.1248/cpb.c16-00126
130005160079
Volume: 36 Issue: 5 Pages: 2946-2950
10.3892/or.2016.5122
Sci. Rep
Volume: 6 Issue: 1 Pages: 36289-36289
10.1038/srep36289