Research Project
Grant-in-Aid for Challenging Exploratory Research
NO generation ability was installed in nanoparticles which forms gel under the physiological conditions. The obained NO-release injectable gel was administered to the myocardial infarction region and the formed gel in myocardium improves long-term retention and continuous generation of NO and increases blood flow and new blood vessels. The objective of this work was to improve angiogenesis of myocardial infarction using our NO-releasing injectable gel. In addition, an ROS elimination function was added to the NO-releasing injectable gel, which avoided consumption of the generated NO and improved therapeutic efficacy.
All 2018 2017
All Journal Article (11 results) (of which Int'l Joint Research: 5 results, Peer Reviewed: 11 results, Open Access: 10 results) Presentation (57 results) (of which Int'l Joint Research: 18 results, Invited: 16 results) Book (2 results)
Cardiovasc Drugs Ther.
Volume: 31 Issue: 5-6 Pages: 501-510
10.1007/s10557-017-6758-6
Biomaterials
Volume: 142 Pages: 162-170
10.1016/j.biomaterials.2017.07.015
Advanced Healthcare Materials
Volume: 6 Issue: 20
10.1002/adhm.201700428
Stroke
Volume: 48 Issue: 8 Pages: 2238-2247
10.1161/strokeaha.116.016356
Sci Rep
Volume: 7 Issue: 1 Pages: 3785-3785
10.1038/s41598-017-03411-7
120007128892
Acta Biomaterialia
Volume: 57 Pages: 127-135
10.1016/j.actbio.2017.04.031
Volume: 134 Pages: 143-153
10.1016/j.biomaterials.2017.04.038
Biological and Pharmaceutical Bulletin
Volume: 40 Issue: 6 Pages: 941-944
10.1248/bpb.b17-00155
130005688066
Volume: 129 Pages: 68-82
10.1016/j.biomaterials.2017.03.011
Polymer
Volume: 116 Pages: 429-438
10.1016/j.polymer.2017.02.052
J. Biomater. Sci. Polym. Ed.
Volume: 印刷中 Issue: 10-12 Pages: 1036-1050
10.1080/09205063.2017.1288774