Design of injectable gel with NO releasing properties and its application

• Project/Area Number: 16K15628
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular surgery
• Research Institution: University of Tsukuba
• Principal Investigator: NAGASAKI Yukio 筑波大学, 数理物質系, 教授 (90198309)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 一酸化窒素 / インジェクタブルゲル / 心筋梗塞 / 虚血性疾患 / アルギニン / 誘導型一酸化窒素合成酵素 / ブロック共重合体 / フラワーミセル / 血管新生 / 活性酸素種 / ナノメディシン / DDS

Outline of Final Research Achievements

NO generation ability was installed in nanoparticles which forms gel under the physiological conditions. The obained NO-release injectable gel was administered to the myocardial infarction region and the formed gel in myocardium improves long-term retention and continuous generation of NO and increases blood flow and new blood vessels. The objective of this work was to improve angiogenesis of myocardial infarction using our NO-releasing injectable gel. In addition, an ROS elimination function was added to the NO-releasing injectable gel, which avoided consumption of the generated NO and improved therapeutic efficacy.

Research Products

• [Journal Article] Novel Synthesized Radical-Containing Nanoparticles Limit Infarct Size Following Ischemia and Reperfusion in Canine Hearts. (2017)
  • Author(s): Asanuma H, Sanada S, Yoshitomi T, Sasaki H, Takahama H, Ihara M, Takahama H, Shinozaki Y, Mori H, Asakura M, Nakano A, Sugimachi M, Asano Y, Minamino T, Takashima S, Nagasaki Y, Kitakaze M.
  • Journal Title: Cardiovasc Drugs Ther. Volume: 31 Issue: 5-6 Pages: 501-510
  • DOI: 10.1007/s10557-017-6758-6
  • Peer Reviewed / Open Access
• [Journal Article] Oral nanotherapeutics: Redox nanoparticles attenuate ultraviolet B radiation-induced skin inflammatory disorders in Kud:Hr- hairless mice (2017)
  • Author(s): Feliciano Chitho P.、Nagasaki Yukio
  • Journal Title: Biomaterials Volume: 142 Pages: 162-170
  • DOI: 10.1016/j.biomaterials.2017.07.015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Newly Designed Silica-Containing Redox Nanoparticles for Oral Delivery of Novel TOP2 Catalytic Inhibitor for Treating Colon Cancer (2017)
  • Author(s): Vong Long Binh、Kimura Shinya、Nagasaki Yukio
  • Journal Title: Advanced Healthcare Materials Volume: 6 Issue: 20
  • DOI: 10.1002/adhm.201700428
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neurovascular Unit Protection From Cerebral Ischemia-Reperfusion Injury by Radical-Containing Nanoparticles in Mice (2017)
  • Author(s): Hosoo H, Marushima A, Nagasaki Y, Hirayama A, Ito H, Puentes S, Mujagic A, Tsurushima H, Tsuruta W, Suzuki K, Matsui H, Matsumaru Y, Yamamoto T, Matsumura
  • Journal Title: Stroke Volume: 48 Issue: 8 Pages: 2238-2247
  • DOI: 10.1161/strokeaha.116.016356
  • Peer Reviewed / Open Access
• [Journal Article] Chronic treatment with a smart antioxidative nanoparticle for inhibition of amyloid plaque propagation in Tg2576 mouse model of Alzheimer’s disease (2017)
  • Author(s): Boonruamkaew Phetcharat、Chonpathompikunlert Pennapa、Vong Long Binh、Sakaue Sho、Tomidokoro Yasushi、Ishii Kazuhiro、Tamaoka Akira、Nagasaki Yukio
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 3785-3785
  • DOI: 10.1038/s41598-017-03411-7
  • NAID: 120007128892
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Development of a local anesthetic lidocaine-loaded redox-active injectable gel for postoperative pain management (2017)
  • Author(s): Nagasaki Yukio、Mizukoshi Yutaro、Gao Zhenyu、Feliciano Chitho P.、Chang Kyungho、Sekiyama Hiroshi、Kimura Hiroyuki
  • Journal Title: Acta Biomaterialia Volume: 57 Pages: 127
  • DOI: 10.1016/j.actbio.2017.04.031
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Application of surface enhanced Raman spectroscopy as a diagnostic system for hypersialylated metastatic cancers (2017)
  • Author(s): Shashni Babita、Horiguchi Yukichi、Kurosu Kosuke、Furusho Hitoshi、Nagasaki Yukio
  • Journal Title: Biomaterials Volume: 134 Pages: 143-153
  • DOI: 10.1016/j.biomaterials.2017.04.038
  • Peer Reviewed / Open Access
• [Journal Article] Prevention of UV-Induced Melanin Production by Accumulation of Redox Nanoparticles in the Epidermal Layer <i>via</i> Iontophoresis (2017)
  • Author(s): Shiota K, Hama S, Yoshitomi T, Nagasaki Y, Kogure K.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 40 Issue: 6 Pages: 941-944
  • DOI: 10.1248/bpb.b17-00155
  • NAID: 130005688066
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Open Access
• [Journal Article] Long-term bioavailability of redox nanoparticles effectively reduces organ dysfunctions and death in whole-body irradiated mice (2017)
  • Author(s): Feliciano Chitho P.、Tsuboi Koji、Suzuki Kenshi、Kimura Hiroyuki、Nagasaki Yukio
  • Journal Title: Biomaterials Volume: 129 Pages: 68-82
  • DOI: 10.1016/j.biomaterials.2017.03.011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nitroxide radical-containing nanoparticles as potential candidates for overcoming drug resistance in epidermoid cancers (2017)
  • Author(s): Shashni Babita、Alshwimi Abdulaziz、Minami Kentaro、Furukawa Tatsuhiko、Nagasaki Yukio
  • Journal Title: Polymer Volume: 116 Pages: 429-438
  • DOI: 10.1016/j.polymer.2017.02.052
  • Peer Reviewed / Open Access
• [Journal Article] Development of Gd3N@C80 encapsulated redox nanoparticles for high-performance magnetic resonance imaging (2017)
  • Author(s): Zhenyu Gao, Yusuke Nakanishi, Shoko Noda, Haruka Omachi, Hisanori Shinohara, Hiroyuki Kimura and Yukio Nagasaki
  • Journal Title: J. Biomater. Sci. Polym. Ed. Volume: 印刷中 Issue: 10-12 Pages: 1036-1050
  • DOI: 10.1080/09205063.2017.1288774
  • Peer Reviewed
• [Presentation] 機能性PEGの設計と展開 (2018)
  • Author(s): 長崎幸夫
  • Organizer: 第68回高分子学会医用高分子研究会
  • Invited
• [Presentation] 抗酸化能を有するナノメディシンの開発 (2018)
  • Author(s): 長崎幸夫
  • Organizer: 第34回日本毒性病理学会学術集会
  • Invited
• [Presentation] 抗酸化ナノメディシンの開発と機能 (2018)
  • Author(s): 長崎幸夫
  • Organizer: 国立感染症研究所学友会シンポジウム
  • Invited
• [Presentation] Long-term bioavailability of redox nanoparticles effectively reduces organ dysfunctions and death in whole-body irradiated mice (2018)
  • Author(s): Yukio Nagasaki, Koji Tsuboi, Kenshi Suzuki, Hiroyuki Kimura, Chitho P. Feliciano
  • Organizer: 8th Annual Meeting of the International Society of Radiation Neurobiology (ISRN2018)
  • Int'l Joint Research
• [Presentation] Neurovascular Unit Protection Using Nitroxide Radicals-containing Nanoparticles (TEMPO-RNP) for Cerebral Ischemia-reperfusion Injury in Mice (2018)
  • Author(s): Hisayuki Hosoo, Aiki Marushima, Yukio Nagasaki, Aki Hirayama, Hiromu Ito, Sandra Puentes, Arnela Mujagic, Hideo Tsurushima, Wataro Tsuruta, Kensuke Suzuki, Hirofumi Matsui, Yuji Matsumaru, Tetsuya Yamamoto, Akira Matsumura
  • Organizer: International Stroke Conference 2018
  • Int'l Joint Research
• [Presentation] ラットインプラント周囲炎モデルに対するレドックスインジェクタブルゲルの抗酸化作用 (2018)
  • Author(s): 小澤僚太郎、斉田牧子、坂上 奨、丸尾勝一郎、川股亮太、櫻井 孝、長崎幸夫、木本克彦
  • Organizer: 日本補綴歯科学会西関東支部学術大会
• [Presentation] Novel Antioxidative Nanotherapeitics by Nitroxide-radical Containing Polymer Nanoparticles (2017)
  • Author(s): Yukio Nagasaki
  • Organizer: the 8th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10
  • Int'l Joint Research / Invited
• [Presentation] Design of Antioxidative Biointerface (2017)
  • Author(s): Yukio Nagasaki
  • Organizer: The 8th International Symposium on Surface Science (ISSS)
  • Int'l Joint Research / Invited
• [Presentation] Design of silica-containing redox nanoparticles for high-performance nanotherapeutics, The 5th International Symposium on Smart Biomaterials---the 5th Hoffman Family Symposium, Shanghai, China (2017)
  • Author(s): Yukio Nagasaki
  • Organizer: The 5th International Symposium on Smart Biomaterials---the 5th Hoffman Family Symposium
  • Int'l Joint Research / Invited
• [Presentation] Design of redox nanomedicine (2017)
  • Author(s): Yukio Nagasaki
  • Organizer: 1st Minisymposium on Material Biology
  • Invited
• [Presentation] レドックスインジェクタブルゲルの設計と評価 (2017)
  • Author(s): 長崎幸夫
  • Organizer: ゲルワークショップ イン 松山
  • Invited
• [Presentation] Construction of Nitroxyl Radical Containing Polymer and its Application for Drug Development and Medical Device (2017)
  • Author(s): Yutaka Ikeda, Yukio Nagasaki
  • Organizer: 8-th Spin Conference on Nitroxides (SPIN2017)
  • Invited
• [Presentation] Antioxidative nanomedicine for colitis and cancer (2017)
  • Author(s): Long Binh Vong, Yukio Nagasaki
  • Organizer: The 10th Vietnam-Japan Scientific Exchange Meeting (VJSE2017)
  • Int'l Joint Research / Invited
• [Presentation] Antioxidative Nanotherapeutics (2017)
  • Author(s): Yukio Nagasaki
  • Organizer: Biomaterials International 2017
  • Int'l Joint Research / Invited
• [Presentation] A novel biointerface that suppresses blood coagulation and cell morphological changes by scavenging excess reactive oxygen species (2017)
  • Author(s): Yukio Nagasaki
  • Organizer: The 15th International Conference on Advanced Materials (IUMRS-ICAM2017),
  • Int'l Joint Research / Invited
• [Presentation] 抗酸化ナノメディシンの設計と評価 (2017)
  • Author(s): 長崎幸夫
  • Organizer: 高分子学会関東支部湘南地区講演会
  • Invited
• [Presentation] Redox polymer nanotherapeutics: A safe and effective therapy in gastrointestinal disorder and cancer (2017)
  • Author(s): Long Binh Vong, Yukio Nagasaki
  • Organizer: The International Symposium on Pure & Applied Chemistry (ISPAC) 2017
  • Int'l Joint Research / Invited
• [Presentation] ナノメディシンを目指したレドックスポリマーの設計と応用 (2017)
  • Author(s): 長崎幸夫
  • Organizer: 第66回高分子学会春季年会
  • Invited
• [Presentation] Newly Designed Antioxidative Nanomedicine (2017)
  • Author(s): Yukio Nagsaki
  • Organizer: Tilateral Japan-Israel-Czech Republic International Symposium of Polymer Therapeutics Focusing on the Targeted Nanomedicines
  • Int'l Joint Research / Invited
• [Presentation] Novel Nanomedicine for Protection against the Late-Effects of Ionizing Radiation (2017)
  • Author(s): Chitho Parayno Feliciano, Yukio Nagasaki
  • Organizer: the 8th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10
  • Int'l Joint Research
• [Presentation] Therapeutic improvement in bacterial infection by antioxidative nanoparticle (2017)
  • Author(s): Yutaka Ikeda, Kazuhiro Shoji, Chitho Feliciano, Shinji Saito, Yukio Nagasaki,
  • Organizer: the 8th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10
  • Int'l Joint Research
• [Presentation] Regulation of redox equilibrium in colitis and colon cancer by specific accumulation of orally administered redox nanoparticles (2017)
  • Author(s): Long Binh Vong, Yukio Nagasaki
  • Organizer: the 8th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10
  • Int'l Joint Research
• [Presentation] 大気圧プラズマを用いた抗酸化機能を有する界面の構築 (2017)
  • Author(s): 池田 豊、北野 勝久、 長崎幸夫
  • Organizer: 第27回日本MRS年次大会
• [Presentation] 性酸素種除去能を有する培養表面による間葉系幹細 胞の幹細胞性の維持 (2017)
  • Author(s): 犬塚直希、池田 豊、後藤光昭、赤池敏弘、 長崎幸夫
  • Organizer: 第27回日本MRS年次大会
• [Presentation] ovel Cardiovascular Therapeutics by Redox Injectable Hydrogel -Effective Maintenance of Local Nitric Oxide Generation to Induce Angiogenesis (2017)
  • Author(s): Long Binh Vong, Quoc Thang Bui, Tsutomu Tomita, Hiroaki Sakamoto, Yuji Hiramatsu, Yukio Nagasaki
  • Organizer: The 3rd International Inovation in Cancer Research and Regenerative Medicine
  • Int'l Joint Research
• [Presentation] Oral redox nanotherapeutics for treatment of ulcerative colitis and colon cancer (2017)
  • Author(s): Long Bih Vong, Yukio Nagasaki
  • Organizer: 254th American Chemical Society National Meeting
  • Int'l Joint Research
• [Presentation] Novel Cardiovascular Therapeutics by Redox Injectable Hydrogel - Effective Maintenance of Local Nitric Oxide Generation to Induce Angiogenesis (2017)
  • Author(s): Long Bih Vong, Thang Bui, Tsutomu Tomita, Hiroaki Sakamoto, Yuji Hiramatsu,Yukio Nagasaki
  • Organizer: 254th American Chemical Society National Meeting
  • Int'l Joint Research
• [Presentation] セラグノーシスを目指した多機能性イオンデリバリー システムの開発 (2017)
  • Author(s): 金 雅覧、 長崎幸夫
  • Organizer: 第27回日本MRS年次大会
• [Presentation] pH and Temperature Dependent Structure of MeO-PEG-b-PMNT/PAAc polyion complexes (2017)
  • Author(s): Masato Takahashi, Yukio Nagasaki
  • Organizer: The 15th International Conference on Advanced Materials
  • Int'l Joint Research
• [Presentation] Novel Gd3N@C80 encapsulated redox nano-contrast agent for magnetic resonance imaging: high contrast and suppression of adverse effect (2017)
  • Author(s): Zhenyu Gao, Yusuke Nakanishi, Shoko Noda, Haruka Omachi, Hisanori Shinohara, Hiroyuki Kimura, and Yukio Nagasakia
  • Organizer: 2017 Conference of the Federation of Asian Society for Molecular Imaging (FASMI 2017)
  • Int'l Joint Research
• [Presentation] 抗酸化ナノメディシンを用いた重度感染治療法の開発 (2017)
  • Author(s): 池田 豊, 庄司和弘，ChithoP.Feliciano, 斎藤慎二，長崎幸夫
  • Organizer: 第39回日本バイオマテリアル学会大会
• [Presentation] ナノ粒子ホウ素薬剤の設計と評価 (2017)
  • Author(s): 長崎幸夫
  • Organizer: 第14回日本中性子捕捉療法学会学術集会
• [Presentation] Application of Surface-Enhanced Raman Spectroscopy for Detection of Hypersialylated Metastatic Cancers (2017)
  • Author(s): Babita Shashni, Yukichi Horiguchi, Kosuke Kurosu, Hitoshi Furusho, Yukio Nagasaki
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] Unexpectedly suppressed adverse effect of chemotherapeutics by intestinally accumulated antioxidative nanoparticle (2017)
  • Author(s): Long B. Vong, Shinya Kimura, Yukio Nagasaki
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] TEMPO含有高分子とPEGからなる二元および三元 ブロック共重合体のミセル構造 (2017)
  • Author(s): 高橋 倫太郎、三輪 祥多郎、藤井 翔太、Vong B. Long、長崎 幸夫、櫻井和朗
  • Organizer: 第66回高分子学会討論会
• [Presentation] 柔らかな生体高分子の特徴を活用した新規超分子 光不斉反応系の開発と反応機構の解明 (2017)
  • Author(s): 豊岡 壮太、奥木 暢、藤城 祐也、西嶋 政樹、荒木 保幸、坂本 清志、池田 豊、高井 まどか、長崎 幸夫、井上 佳久、和田 健彦
  • Organizer: 第66回高分子学会討論会
• [Presentation] Regulation of nitric oxide release by poly(arginine)-assisted redox injectable hydrogel in cardiovascular therapeutics (2017)
  • Author(s): Binh Long Vong, Quoc Thang Bui, Tsutomu Tomita, Hiroki Sakamoto, Yuji Hiramatsu, Yukio Nagasaki
  • Organizer: 第66回高分子学会討論会
• [Presentation] サンゴ共生体の保護を目指した取り組み ―抗活性酸素剤による高温ストレス下でのサンゴ幼生の生存率の向上― (2017)
  • Author(s): 元根 啓佑、高木 俊幸、油屋 駿介、新里 宙也、長崎 幸夫、竹山 春子、青木 航、植田 充美
  • Organizer: 環境微生物系学会合同大会2017
• [Presentation] 細胞の品質管理を可能にする培養機材表面の構築-大気圧プラズマを用いた検討-、 (2017)
  • Author(s): 池田 豊、北野勝久、長崎幸夫
  • Organizer: 第46回高分子学会医用高分子研究会
• [Presentation] エキセナチドをコントロールドリリース可能な抗酸化インジェクタブルゲルによる2型糖尿 病治療 (2017)
  • Author(s): 坂上 奨 、石井 志郎 、長崎 幸夫
  • Organizer: 日本DDS学会第33回学術集会
• [Presentation] 抗酸化作用を持つナノメディシンの重度感染症治療への応用 (2017)
  • Author(s): 池田 豊、庄司 和弘 、Chitho Feliciano 、斎藤 慎二 、長崎 幸夫
  • Organizer: 日本DDS学会第33回学術集会
• [Presentation] Silica-containing redox nanoparticles for oral cancer therapeutics of novel topoisomerase II inhibitor (2017)
  • Author(s): Binh Long Vong ,Shinya Kimura ,Yukio Nagasaki
  • Organizer: 日本DDS学会第33回学術集会
• [Presentation] 抗酸化ナノ粒子による肝臓疾患治療への道 (2017)
  • Author(s): 長崎幸夫
  • Organizer: 第24回肝細胞研究会
• [Presentation] In vitro三次元培養を可能にする機能ハイドロゲル創製における酸化ストレス 除去の必要性 (2017)
  • Author(s): 中路 正、池田 豊、長崎幸夫
  • Organizer: 第70回日本酸化ストレス学会学術集会
• [Presentation] 抗酸化ナノメディシンの感染症治療への展 (2017)
  • Author(s): 池田 豊、庄司 和弘、Chitho Feliciano、斎藤 慎二、長崎幸夫
  • Organizer: 第70回日本酸化ストレス学会学術集会
• [Presentation] ROS-scavenging nanoparticle for oral delivery of novel TOP2 inhibitor in treating colon cancer (2017)
  • Author(s): Long Binh Vong,Shinya Kimura, Yukio Nagasaki
  • Organizer: 第70回日本酸化ストレス学会学術集会
• [Presentation] Chronic treatment with a smart antioxidative nanoparticle for inhibition of amyloid plaque propagation in Tg2576 mouse model of Alzheimer's disease (2017)
  • Author(s): Boonruamkaew Phetcharat,Chonpathompikunlert Pennapa,Vong Binh Long,坂上 奨, 冨所 康志,石井 一弘,玉岡 晃,長崎幸夫
  • Organizer: 第70回日本酸化ストレス学会学術集会
• [Presentation] ホウ素含有レドックスナノ粒子:活性酸素種除去することにより高質なホウ素 捕捉療法を目指す (2017)
  • Author(s): 高 振宇、堀口 諭吉、中井 啓、松村 明、鈴木 実、小野 公二、長崎幸夫
  • Organizer: 第70回日本酸化ストレス学会学術集会
• [Presentation] Novel Gd3N@C80 encapsulated redox contrast agent for magnetic resonance imaging with high contrast and low adverse effect (2017)
  • Author(s): 高 振宇、中西 勇介、野田 祥子、大町 遥、篠原 久典、木村 寛之、長崎幸夫
  • Organizer: 第70回日本酸化ストレス学会学術集会
• [Presentation] エキセナチドを徐放する抗酸化インジェクタブルゲルによる新しい2型糖尿病 治療 (2017)
  • Author(s): 坂上 奨、石井 志郎、長崎幸夫
  • Organizer: 第70回日本酸化ストレス学会学術集会
• [Presentation] Diagnosis of Hypersialylated Metastatic Cancers by Phenylboronic Acid-installed PEGylated Gold Nanoparticle (2017)
  • Author(s): Shashni Babita,Horiguchi Yukichi,Kurosu Kosuke,Furusho Hitoshi,Nagasaki Yukio
  • Organizer: 第70回日本酸化ストレス学会学術集会
• [Presentation] 疼痛治療を目指した局所麻酔薬担持レドックスインジェクタブルゲルの開発 (2017)
  • Author(s): 水越 雄太郎、高 振宇、Chitho Feliciano、張 京浩、関山 裕詩、木村 寛之、長崎幸夫
  • Organizer: 第70回日本酸化ストレス学会学術集会
• [Presentation] 新規活性酸素消去剤RNPによる 脳虚血再灌流障害に対するneuro-endthelial protection効果の検証 (2017)
  • Author(s): 細尾 久幸、丸島 愛樹、長崎 幸夫、平山 暁、伊藤 紘、Sandra Puentes、Arnela Mujagic、 鶴嶋 英夫、松井 裕史、鶴田 和太郎、鈴木 謙介、山本 哲哉、松丸 祐司、松村 明
  • Organizer: 第70回日本酸化ストレス学会学術集会
• [Presentation] Dvelopment of silica-containing redox nanoparticles for oral drug delivery to treat colon cancer (2017)
  • Author(s): Long Binh Vong,Shinya Kimura,Yukio Nagasaki
  • Organizer: 第66回高分子学会春季年会
• [Presentation] Design of GLP-1 Analog Loaded Redox-Active Injectable Gel as A Novel Anti-Diabetic Drug (2017)
  • Author(s): Sho Sakaue, Shiro Ishii,Yukio Nagasaki
  • Organizer: 第66回高分子学会春季年会
• [Presentation] Surface construction of anti-oxidative cell culture dish preventing cell dysfunction -Application for various substrates by using atmospheric plasma (2017)
  • Author(s): Yutaka Ikeda, Katsuhisa Kitanon, Yukio Nagasaki
  • Organizer: 第66回高分子学会春季年会
• [Presentation] Controllable NO releasing redox injectable hydrogel for myocardial infarction model in mice (2017)
  • Author(s): Long Binh Vong, Quoc Thang Bui, Tomita Tsutomu, Hiroaki Sakamoto, Yuji Hiramatsu, Yukio Nagasaki
  • Organizer: 第17回日本ＮＯ学会学術集会
• [Book] ACS Symposium Series 1253 (2017)
  • Author(s): Long Binh Vong, Yukio Nagasaki
  • Publisher: American Chemical Society
• [Book] CSJカレントレビュー、日本化学会編 (2017)
  • Author(s): 長崎幸夫
  • Publisher: 化学同人