analysis of calcification process in implanted arterial artificial-graft.
| Project/Area Number |
16K15632
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Cardiovascular surgery
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
KUROBE Hirotsugu 徳島大学, 大学院医歯薬学研究部(医学系), 助教 (30380083)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
吉田 守美子 徳島大学, 大学院医歯薬学研究部, 講師 (40510904)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 生体分解性ポリマー / 血管移植 / 血管再生 / 石灰化 / 遺伝子発現解析 / 末梢静脈外科学 |
|---|
| Outline of Final Research Achievements |
Purpose of his study clarify the of calcification process in implanted arterial artificial-graft. Artificial arterial graft was implanted to abdominal aorta in 49 mice, and we explanted the implanted grafts from 39 mice at 2 months after implantation. By X-ray analysis, 14 explanted grafts occurred calcification. We divided 2 groups; Group C in 14 grafts with calcification, and Group N is 25 grafts without calcification.
By microarray analysis with both groups, we picked up genes which was more than 2 fold in Fold Change analysis. And, by real time PCR was done in these picked up 22 genes, we think 4 genes (collagen X、osx、win3a、ankrd2) were associated with calcification process. We are doing more analysis to clarify the relation of these 4 genes for calcification process after graft-implanting.
|
Report
(3 results)
Research Products
(75 results)
-
-
-
-
-
-
-
-
[Journal Article] Effects of Transplanted Human Cord Blood- Mononuclear Cells on Pulmonary Hypertension in Immunodeficient Mice and Their Distribution.2017
Author(s)
Mikio Sugano, Homare Yoshida, Hirotsugu Kurobe, Arase Hiroki, Hajime Kinoshita, Takashi Kitaichi, Noriko Sugasawa, Soichiro Nakayama, Kazuhisa Maeda, Minoru Irahara, Tetsuya Kitagawa
-
Journal Title
J Med Invest
Volume: 64
Pages: 43-49
NAID
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Long-term Results After Open Mitral Commissurotomy for a One-Month-Old Infant With Mitral Stenosis.2017
Author(s)
Takashi Kitaichi, Mikio Sugano, Hiroki Arase, Yohei Kawatani, Kanako Kameta, Hirotsugu Kurobe, Eiki Fujimoto, Akemi Ono, Yasunobu Hayabuchi, Hiroshi Fujita, Hitoshi Sogabe, Tetsuya Kitagawa
-
Journal Title
J Med Invest
Volume: 64
Pages: 187-191
NAID
Related Report
Peer Reviewed / Open Access
-
-
-
[Journal Article] The pathophysiological role of oxidized cholesterols in epicardial fat accumulation and cardiac dysfunction: a study in swine fed a high caloric diet with an inhibitor of intestinal cholesterol absorption, ezetimibe.2016
Author(s)
Shimabukuro M, Okawa C, Yamada H, Yanagi S, Uematsu E, Sugasawa N, Kurobe H, Hirata Y, Kim-Kaneyama JR, Lei XF, Takao S, Tanaka Y, Fukuda D, Yagi S, Soeki T, Kitagawa T, Masuzaki H, Sato M, Sata M.
-
Journal Title
J Nutr Biochem.
Volume: 35
Pages: 66-73
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 弓部大動脈瘤に対する2 debranch TEVARの治療成績の検討2017
Author(s)
藤本鋭貴, 筑後文雄, 亀田香奈子, 川谷洋平, 荒瀬裕己, 菅野幹雄, 黒部裕嗣, 割石精一郎, 加納正志, 北市 隆, 北川哲也
Organizer
第45回日本血管外科学会学術総会
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
