New preservation system for donor lung

• Project/Area Number: 16K15635
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: Tohoku University
• Principal Investigator: MASAFUMI NODA 東北大学, 大学病院, 講師 (70400356)
• Co-Investigator(Kenkyū-buntansha): 松田 安史 東北大学, 大学病院, 助教 (00455833) ; 岡田 克典 東北大学, 加齢医学研究所, 教授 (90323104) ; 星川 康 藤田医科大学, 医学部, 教授 (90333814)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
• Keywords: 低温持続換気保存 / 臓器移植 / 肺移植 / CVLP / 急性肺障害 / ドナー肺 / 肺保存 / 移植・再生医療

Outline of Final Research Achievements

We investigated continuously ventilated lung preservation using pig model.
CVLP is possible to preserve donor lung functions.

Academic Significance and Societal Importance of the Research Achievements

脳死肺移植において、ドナー不足は喫緊の課題であり、数少ないドナー肺を有効に利用するため、本アプローチが将来的に臨床応用可能になることで、多くのドナー肺利用が可能となる。

Research Products

• [Journal Article] Animal ethics and welfare education in wet-lab training can foster residents’ ethical values toward life (2017)
  • Author(s): Iki Y, Ito T, Kudo K, Noda M, Kanehira M, Sueta T, Miyoshi I, Kagaya Y, Okada Y, Unno M
  • Journal Title: Experimental Animals Volume: 66 Issue: 4 Pages: 313-320
  • DOI: 10.1538/expanim.17-0026
  • NAID: 130006187189
  • ISSN: 0007-5124, 1341-1357, 1881-7122
  • Peer Reviewed
• [Journal Article] Surgical Training Utilizing Swine Under General Anesthesia and Animal Ethics (2017)
  • Author(s): Iki Y, Noda M, Kudoh K, Sueta T, Kanehira M, Ito T, Matsuda Y, Okada Y, Unno M.
  • Journal Title: Kyobu Geka Volume: 70 Pages: 329-333
  • NAID: 40021199347