Comprehensive analyses of transcriptome and DNA copy number variations in thymic cancer
| Project/Area Number |
16K15636
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
Date Hiroshi 京都大学, 医学研究科, 教授 (60252962)
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| Co-Investigator(Kenkyū-buntansha) |
園部 誠 京都大学, 医学研究科, 准教授 (00432378)
毛受 暁史 京都大学, 医学(系)研究科(研究院), その他 (30527081)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 胸腺癌 / トランスクリプトーム / DNAコピー数変化 / 胸腺上皮性腫瘍 / 遺伝子発現 / コピー数 / 胸腺腫瘍 / コピー数異常 / クラスター解析 |
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| Outline of Final Research Achievements |
The analyses of the expressions of mRNA and the copy number variation of DNA in thymic epithelial tumors were performed by using HTA2.0 and Oncoscan of Affymetrix, and were integrated by the software, iClusterPlus. The unsupervised clustering showed that these samples were almost classified into the groups according to their histological types. Furthermore, the recurrent case of type B3 thymoma was classified to the group of type C. On the other hand, type C thymic cancer without recurrence was classified to the group of type B2/3. These results proved that integrated data of mRNA and CNV of DNA in addition to the histological types probably work as the more accurate prognostic factor.
In future, we have a plan that the molecular expressions specific to thymic carcinoma are examined by immunohistochemical stainings of our clinical samples and integrated with the analyzed genetic data.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Cancer cell invasion driven by extracellular matrix remodeling is dependent on the properties of cancer-associated fibroblasts.2016
Author(s)
Neri S, Hashimoto H, Kii H, Watanabe H, Masutomi K, Kuwata T, Date H, Tsuboi M, Goto K, Ochiai A, Ishii G.
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Journal Title
J Cancer Res Clin Oncol
Volume: 142(2)
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Surgical and non-surgical management of repeat pulmonary metastasis from sarcoma following first pulmonary metastatectomy.2016
Author(s)
Hamaji M, Chen F, Miyamoto E, Kondo T, Ohata K, Motoyama H, Hijiya K, Menju T, Aoyama A, Sato T, Sonobe M, Date H.
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Journal Title
Surg Today
Volume: 46(11)
Pages: 1296-1300
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Is volumetric 3-dimensional computed tomography useful to predict histological tumour invasiveness? Analysis of 211 lesions of cT1N0M0 lung adenocarcinoma.2016
Author(s)
Shikuma K, Menju T, Chen F, Kubo T, Muro S, Sumiyoshi S, Ohata K, Sowa T, Nanaknishi T, Cho H, Neri S, Aoyama A, Sato T, Sonobe M, Date H.
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Journal Title
Interact Cardiovasc Thorac Surg
Volume: 22(6)
Pages: 831-8
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Trametinib plus 4-methylumbelliferone exhibits antitumor effects by ERK blockade and CD44 downregulation and affects PD1 and PD-L1 in malignant pleural mesothelioma.2016
Author(s)
Cho H, Matsumoto S, Fujita Y, Kuroda A, Menju T, Sonobe M, Kondo N, Torii I, Nakano T, Lara PN, Gandara DR, Date H, Hasegawa S.
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Journal Title
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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