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Establishment of diffuse astrocytoma cell line utilizing advanced culture system

Research Project

Project/Area Number 16K15641
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionKumamoto University (2017-2018)
The University of Tokyo (2016)

Principal Investigator

Mukasa Akitake  熊本大学, 大学院生命科学研究部(医), 教授 (90463869)

Research Collaborator TANAKA shota  
TAKAYANAGI shunsaku  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords神経膠腫 / 星細胞腫 / IDH遺伝子 / 細胞モデル / 星細胞種
Outline of Final Research Achievements

It is essential that we use cell lines to develop treatment for the most frequently occurring malignant brain tumor, namely glioma. However, few cell lines of IDH-mutant glioma, which often occurs in the young, are available. Thus, in this study, we tried to establish these cell lines by taking advantage of the following advanced techniques; 1) the use of various three-dimensional culture methods, 2) the introduction of oncogenic gene alterations into normal human astrocytes, 3) the primary culture of surgically resected specimens of IDH-mutant gliomas, and the production of iPS cell lines from these cultured cells. We could not establish an ideal model cell line, however, we obtained a lot of useful technical information that can be used for the future development of IDH-mutant glioma cell lines.

Academic Significance and Societal Importance of the Research Achievements

今回細胞株樹立を目指したIDH遺伝子変異を有す星細胞腫は、若年層に好発する神経膠腫であり、罹患による社会的損失も大きく、その治療法開発は急務である。今回その細胞株樹立のために有用な技術基盤の情報を多く得ることができた。また、この星細胞腫樹立のために種々の先端的培養法を試みることで、それぞれの技術的限界や今後の改善すべき点を確認することができたことは、他の分野にも応用可能な知識で有り意義深い事項である。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (46 results)

All 2019 2018 2017 2016

All Journal Article (24 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 22 results,  Open Access: 16 results) Presentation (20 results) (of which Int'l Joint Research: 8 results,  Invited: 10 results) Book (2 results)

  • [Journal Article] Pattern of FDG and MET Distribution in High- and Low-Grade Gliomas on PET Images.2019

    • Author(s)
      Takahashi M, Soma T, Mukasa A, Tanaka S, Yanagisawa S, Momose T.
    • Journal Title

      Clinical Nuclear Medicine

      Volume: - Issue: 4 Pages: 265-271

    • DOI

      10.1097/rlu.0000000000002460

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA demethylation is associated with malignant progression of lower-grade gliomas2019

    • Author(s)
      Nomura Masashi、Saito Kuniaki、Aihara Koki、Nagae Genta、Yamamoto Shogo、Tatsuno Kenji、Ueda Hiroki、Fukuda Shiro、Umeda Takayoshi、Tanaka Shota、…、Narita Yoshitaka、Nagane Motoo、Nishikawa Ryo、Ueki Keisuke、Saito Nobuhito、Aburatani Hiroyuki、Mukasa Akitake
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 1903-1903

    • DOI

      10.1038/s41598-019-38510-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oligodendrocyte Progenitor Cells and Macrophages/Microglia Produce Glioma Stem Cell Niches at the Tumor Border.2018

    • Author(s)
      Hide T, Komohara Y, Miyasato Y, Nakamura H, Makino K, Takeya M, Kuratsu JI, Mukasa A, Yano S.
    • Journal Title

      EBioMedicine.

      Volume: 30 Pages: 94-104

    • DOI

      10.1016/j.ebiom.2018.02.024

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Employment status and termination among survivors of pediatric brain tumors: a cross-sectional survey.2018

    • Author(s)
      Sato I, Higuchi A, Yanagisawa T, Murayama S, Kumabe T, Sugiyama K, Mukasa A, Saito N, Sawamura Y, Terasaki M, Shibui S, Takahashi J, Nishikawa R, Ishida Y, Kamibeppu K.
    • Journal Title

      Int J Clin Oncol

      Volume: - Issue: 5 Pages: 801-811

    • DOI

      10.1007/s10147-018-1279-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IDH-mutated astrocytomas with 19q-loss constitute a subgroup that confers better prognosis2018

    • Author(s)
      Otani Ryohei、Uzuka Takeo、Higuchi Fumi、Matsuda Hadzki、Nomura Masashi、Tanaka Shota、Mukasa Akitake、Ichimura Koichi、Kim Phyo、Ueki Keisuke
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 7 Pages: 2327

    • DOI

      10.1111/cas.13635

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Concomitant administration of radiation with eribulin improves the survival of mice harboring intracerebral glioblastoma.2018

    • Author(s)
      Miki S, Imamichi S, Fujimori H, Tomiyama A, Fujimoto K, Satomi K, Matsushita Y, Matsuzaki S, Takahashi M, Ishikawa E, Yamamoto T, Matsumura A, Mukasa A, Nishikawa R, Masutomi K, Narita Y, Masutani M, Ichimura K.
    • Journal Title

      Cancer Sci

      Volume: 109 Issue: 7 Pages: 2275-2285

    • DOI

      10.1111/cas.13637

    • NAID

      120007133981

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] BCL2 expression is associated with a poor prognosis independent of cellular origin in primary central nervous system diffuse large B-cell lymphoma.2018

    • Author(s)
      Makino K, Nakamura H, Shinojima N, Kuroda JI, Yano S, Mikami Y, Mukasa A
    • Journal Title

      Journal of neuro-oncology

      Volume: 140 Issue: 1 Pages: 115-121

    • DOI

      10.1007/s11060-018-2940-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SIRT2-mediated inactivation of p73 is required for glioblastoma tumorigenicity2018

    • Author(s)
      Funato K, Hayashi T, Echizen K, Negishi L, Shimizu N, Koyama-Nasu R, Nasu-Nishimura Y, Morishita Y, Tabar V, Todo T, Ino Y, Mukasa A, Saito N & Akiyama T.
    • Journal Title

      EMBO Reports

      Volume: 19 Issue: 11 Pages: 45587-45587

    • DOI

      10.15252/embr.201745587

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Machine learning based on multi-parametric magnetic resonance imaging to differentiate glioblastoma multiforme from primary cerebral nervous system lymphoma.2018

    • Author(s)
      Nakagawa M, Nakaura T, Namimoto T, Kitajima M, Uetani H, Tateishi M, Oda S, Utsunomiya D, Makino K, Nakamura H, Mukasa A, Hirai T, Yamashita Y
    • Journal Title

      European journal of radiology

      Volume: 108 Pages: 147-154

    • DOI

      10.1016/j.ejrad.2018.09.017

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CSF TACI and BAFF levels in patients with primary CNS lymphoma as novel diagnostic biomarkers.2018

    • Author(s)
      Mizutani H, Nakane S, Ikeda T, Nakamura H, Takamatsu K, Makino K, Tawara N, Mukaino A, Watari M, Matsui H, Mukasa A, Ando Y
    • Journal Title

      Annals of clinical and translational neurology

      Volume: 5 Issue: 12 Pages: 1611-1616

    • DOI

      10.1002/acn3.668

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 脳腫瘍のゲノム診療に向けて2018

    • Author(s)
      武笠 晃丈
    • Journal Title

      Clinical Neuroscience

      Volume: 36 Pages: 539-542

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Clinical significance of polyglutamylation in primary central nervous system lymphoma2018

    • Author(s)
      Shinojima Naoki、Fujimoto Kenji、Makino Keishi、Todaka Kohei、Yamada Kazumichi、Mikami Yoshiki、Oda Kazutaka、Nakamura Kazumi、Jono Hirofumi、Kuratsu Jun-ichi、Nakamura Hideo、Yano Shigetoshi、Mukasa Akitake
    • Journal Title

      Acta Neuropathologica Communications

      Volume: 6 Issue: 1 Pages: 15-15

    • DOI

      10.1186/s40478-018-0522-4

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 神経膠腫の不均一性による治療抵抗性とその治療戦略2018

    • Author(s)
      武笠 晃丈
    • Journal Title

      実験医学

      Volume: 36 Pages: 307-313

    • Related Report
      2017 Research-status Report
  • [Journal Article] Genome-wide DNA methylation profiles identifies primary central nervous system lymphomas as a distinct entity from systemic diffuse large B-cell lymphomas2017

    • Author(s)
      Nakamura T, Yamashita S, Fukumura K, Tanaka K, Nagane M, Narita Y, Mano H, Ushijima T, Ichimura K
    • Journal Title

      Acta Neuropathol

      Volume: 133 Issue: 2 Pages: 321-324

    • DOI

      10.1007/s00401-016-1664-8

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An automated voxel-based method for calculating the reference value for a brain tumour metabolic index using 18F-FDG PET and 11C-Methionine PET.2017

    • Author(s)
      Takahashi, Soma T, Mukasa A, Koyama, Arai T, Momose T.
    • Journal Title

      Ann Nucl Med

      Volume: 31 Issue: 3 Pages: 250-259

    • DOI

      10.1007/s12149-017-1153-8

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences in genetic and epigenetic alterations between von Hippel-Lindau disease-related and sporadic hemangioblastomas of the central nervous system.2017

    • Author(s)
      Takayanagi S, Mukasa A, Tanaka S, Nomura M, Omata M, Yanagisawa S, Yamamoto S, Ichimura K, Nakatomi H, Ueki K, Aburatani H, Saito N
    • Journal Title

      Neuro Oncol.

      Volume: 印刷中 Issue: 9 Pages: 1-7

    • DOI

      10.1093/neuonc/nox034

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brachyury gene copy number gain and activation of the PI3K/Akt pathway: Association with upregulation of oncogenic Brachyury expression in skull base chordoma2017

    • Author(s)
      Otani Ryohei、Mukasa Akitake、Shin Masahiro、Omata Mayu、Takayanagi Shunsaku、Tanaka Shota、Ueki Keisuke、Saito Nobuhito
    • Journal Title

      Journal of Neurosurgery

      Volume: 128 Issue: 5 Pages: 1428

    • DOI

      10.3171/2016.12.jns161444

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Distinct molecular profile of diffuse cerebellar gliomas2017

    • Author(s)
      Nomura M, Mukasa A, Nagae G, Yamamoto S, Tatsuno K, Ueda H, Fukuda S, Umeda T, Suzuki T, Otani R, Kobayashi K, Maruyama T, Tanaka S, Takayanagi S, Nejo T, Takahashi S, Ichimura K, Nakamura T, Muragaki Y, Narita Y, Nagane M, Ueki K, Nishikawa R, Shibahara J, Aburatani H, Saito N
    • Journal Title

      Acta Neuropathologica

      Volume: 134 Issue: 6 Pages: 941-956

    • DOI

      10.1007/s00401-017-1771-1

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spinal Cord Astrocytoma with Isocitrate Dehydrogenase 1 Gene Mutation2017

    • Author(s)
      Takai Keisuke、Tanaka Shota、Sota Takashi、Mukasa Akitake、Komori Takashi、Taniguchi Makoto
    • Journal Title

      World Neurosurgery

      Volume: 108 Pages: 991.e13-991.e16

    • DOI

      10.1016/j.wneu.2017.08.142

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel fusion gene HMGA2-EGFR in glioblastoma2017

    • Author(s)
      Komuro Akiyoshi、Raja Erna、Iwata Caname、Soda Manabu、Isogaya Kazunobu、Yuki Keiko、Ino Yasushi、Morikawa Masato、Todo Tomoki、Aburatani Hiroyuki、Suzuki Hiromichi、Ranjit Melissa、Natsume Atsushi、Mukasa Akitake、Saito Nobuhito、Okada Hitoshi、Mano Hiroyuki、Miyazono Kohei、Koinuma Daizo
    • Journal Title

      International Journal of Cancer

      Volume: 142 Issue: 8 Pages: 1627

    • DOI

      10.1002/ijc.31179

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The significance of histone H3 K27M mutation in brain tumors2017

    • Author(s)
      武笠 晃丈
    • Journal Title

      Progress in Neuro-Oncology

      Volume: 24 Issue: 1 Pages: 7-17

    • DOI

      10.11452/neurooncology.24.1_7

    • NAID

      130005868650

    • ISSN
      1880-0742, 2187-0551
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetic and epigenetic stability of oligodendrogliomas at recurrence.2017

    • Author(s)
      Aihara K, Mukasa A, Nagae G, Nomura M, Yamamoto S, Ueda H, Tatsuno K, Shibahara J, Takahashi M, Momose T, Tanaka S, Takayanagi S, Yanagisawa S, Nejo T, Takahashi S, Omata M, Otani R, Saito K, Narita Y, Nagane M, Nishikawa R, Ueki K, Aburatani H, Saito N
    • Journal Title

      Acta Neuropathol Commun.

      Volume: 5 Issue: 1 Pages: 18-18

    • DOI

      10.1186/s40478-017-0422-z

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas2016

    • Author(s)
      Arita H, Yamasaki K, Matsushita Y, Nakamura T, Shimokawa A, Takami H, Tanaka S, Mukasa A, Shirahata M, Shimizu S, Suzuki K, Saito K, Kobayashi K, Higuchi F, Uzuka T, Otani R, Tamura K, Sumita K, Ohno M, Miyakita Y, Kagawa N, Hashimoto N, Hatae R, Yoshimoto K, Shinojima N, Nakamura H, Kanemura Y, Okita Y, et al.
    • Journal Title

      Acta Neuropathol Commun.

      Volume: 4 Issue: 1 Pages: 79

    • DOI

      10.1186/s40478-016-0351-2

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diagnostic value of glutamate with 2-hydroxyglutarate in magnetic resonance spectroscopy for IDH1 mutant glioma2016

    • Author(s)
      Nagashima H, Tanaka K, Sasayama T, Irino Y, Sato N, Takeuchi Y, Kyotani K, Mukasa A, Mizukawa K, Sakata J, Yamamoto Y, Hosoda K, Itoh T, Sasaki R, Kohmura E.
    • Journal Title

      Neuro Oncol

      Volume: 18(11) Pages: 1559-1568

    • DOI

      10.1093/neuonc/now090

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Molecular characteristics of diffuse cerebellar glioma2018

    • Author(s)
      Akitake Mukasa, Masashi Nomura, Genta Nagae, Shogo Yamamoto, Kenji Tatsuno, Hiroki Ueda, Shiro Fukuda, Takayoshi Umeda, Tomonari Suzuki, Ryohei Otani, Keiichi Kobayashi, Takashi Maruyama, Shota Tanaka, Shunsaku Takayanagi, Takahide Nejo, Satoshi Takahashi, Koichi Ichimura, et al. (26人、1番目)
    • Organizer
      International Conference on Brain Tumor Research & Therapy
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 多様なグリオーマに対する precision medicine の可能性と課題2018

    • Author(s)
      武笠晃丈
    • Organizer
      脳腫瘍の基礎シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Glioma: What does the average neurosurgeon need to know about current progress in molecular biology and how will this affect our treatment strategies?2018

    • Author(s)
      Akitake Mukasa
    • Organizer
      Society of Neurosurgeons of South Africa Congress 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マルチモダリティー時代のグリオーマ治療戦略2018

    • Author(s)
      武笠晃丈
    • Organizer
      日本脳腫瘍の外科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 組織・細胞形態と分子プロファイルの多様性から考える脳腫瘍治療戦略2018

    • Author(s)
      武笠晃丈
    • Organizer
      日本組織細胞化学会総会・学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 脳腫瘍のゲノム医療2018

    • Author(s)
      武笠晃丈
    • Organizer
      日本脳神経外科学会学術総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] グリオーマのゲノム・エピゲノム異常2018

    • Author(s)
      武笠晃丈
    • Organizer
      九州遺伝子診断研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] The characteristics of molecular profile changes in recurrent lower grade gliomas and their implication for therapeutic strategy2017

    • Author(s)
      Akitake Mukasa
    • Organizer
      The 8th Institute for Refractory Cancer Research (IRCR) International Symposium
    • Place of Presentation
      Samsung medical center (Seoul, Korea)
    • Year and Date
      2017-01-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] The characteristics of molecular profile changes in recurrent lower grade gliomas and their implication for therapeutic strategy2017

    • Author(s)
      Akitake Mukasa, Kuniaki Saito, Shota Tanaka, Shunsaku Takayanagi,Yoshitaka Narita, Motoo Nagane, Keisuke Ueki, Ryo Nishikawa, Hiroyuki Aburatani, Nobuhito Saito
    • Organizer
      5th Quadrennial Meeting of the World Federation of Neuro-Oncology Societies
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Spatial Heterogeneity of Molecular Profiles in Gliomas and its Implications for Cell-of-Origin and Targeted Therapy2017

    • Author(s)
      Akitake Mukasa
    • Organizer
      The 72nd Fujihara Seminar
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Genetic and epigenetic stability of oligodendrogliomas at recurrence2017

    • Author(s)
      Akitake Mukasa, Koki Aihara, Masashi Nomura, Shota Tanaka, Junji Shibahara, Yoshitaka Narita, Motoo Nagane, Ryo Nishikawa, Keisuke Ueki, Hiroyuki Aburatani, Nobuhito Saito
    • Organizer
      The 14th Meeting of the Asian Society for Neuro-Oncology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Characteristic molecular profile changes in primary and recurrent gliomas depending on their histopathology2017

    • Author(s)
      Akitake Mukasa, Masashi Nomura, Kuniaki Saito, Koki Aihara, Genta Nagae, Takahide Nejo, Shota Tanaka, Shunsaku Takayanagi, Satoshi Takahashi, Mayu Omata, Taishi Nakamura, Yoshitaka Narita, Yoshihiro Muragaki, Motoo Nagane, Keisuke Ueki, Ryo Nishikawa, Hiroyuki Aburatani, Nobuhito Saito
    • Organizer
      22nd Annual Meeting of the Society of Neuro-Oncology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 再発 oligodendroglioma の ゲノム・エピゲノムの安定性2017

    • Author(s)
      武笠晃丈、相原功輝、野村昌志、田中將太、高柳俊作、永根基雄、成田善孝、植木敬介、油谷浩幸、斉藤延人
    • Organizer
      第34回日本脳腫瘍病理学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Integrated and comparative multi-omics analysis of primary and recurrent glioma and its clinical application2017

    • Author(s)
      Akitake Mukasa, Masashi Nomura, Kuniaki Saito, Koki Aihara, Genta Nagae, Takahide Nejo, Shunsaku Takayanagi, Shota Tanaka, Taishi Nakamura, Yoshitaka Narita, Yoshihiro Muragaki, Motoo Nagane, Keisuke Ueki, Ryo Nishikawa, Hiroyuki Aburatani, Nobuhito Saito
    • Organizer
      第76回日本脳神経外科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 初発・再発神経膠腫のマルチオミクス比較解析から考える悪性転化機序とその治療戦略2017

    • Author(s)
      武笠晃丈、野村昌志、齊藤邦昭、相原功輝、永江玄太、上田 宏生、山本 尚吾、辰野 健二、根城 尭英、高橋 慧、高柳俊作、田中將太、花 大洵、北川陽介、中村大志、成田善孝、村垣善浩、永根基雄、西川 亮、植木敬介、油谷浩幸、斉藤延人
    • Organizer
      第35日本脳腫瘍学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 遺伝子プロファイル解析から考える神経膠腫の診断と治療戦略2016

    • Author(s)
      武笠晃丈
    • Organizer
      Temozolomide Forum in HIROSHIMA 2016
    • Place of Presentation
      リーガロイヤルホテル広島(広島県・広島市)
    • Year and Date
      2016-12-13
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Molecular pathological analysis on IDH-wildtype adult low-grade gliomas2016

    • Author(s)
      Akitake Mukasa, Koki Aihara, Genta Nagae, Junji Shibahara, Shota Tanaka, Shunsaku Takayanagi, Masashi Nomura, Motoo Nagane, Yoshitaka Narita, Keisuke Ueki, Ryo Nishikawa, Hiroyuki Aburatani, Nobuhito Saito
    • Organizer
      21th Annual Meeting of the Society of Neuro-Oncology
    • Place of Presentation
      Farimont Scottsdate Princess Hotel (Scottsdale, Arizona, USA)
    • Year and Date
      2016-11-19
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Influence of anticancer therapy on clonal evolution and intratumoral heterogeneity of gliomas2016

    • Author(s)
      Akitake Mukasa
    • Organizer
      75rd Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-10-08
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 再発神経膠腫の分子遺伝学的変化に基づく治療戦略の構築2016

    • Author(s)
      武笠晃丈、相原功輝、齊藤邦昭、永江玄太、野村昌志、根城 尭英、高柳俊作、田中將太、柳澤 俊介、高橋 慧、西川亮、永根基雄、成田善孝、植木敬介、油谷浩幸、斉藤延人
    • Organizer
      第75回日本脳神経外科学会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2016-09-30
    • Related Report
      2016 Research-status Report
  • [Presentation] グリオーマのゲノム多様性とクローン進化に及ぼす抗がん治療の影響2016

    • Author(s)
      武笠晃丈
    • Organizer
      第21回脳腫瘍の外科学会
    • Place of Presentation
      虎ノ門ヒルズフォーラム(東京都・港区)
    • Year and Date
      2016-09-09
    • Related Report
      2016 Research-status Report
    • Invited
  • [Book] 上衣系腫瘍, グリオーマ治療のDecision Making 脳神経外科診療プラクティス2016

    • Author(s)
      武笠晃丈
    • Total Pages
      4
    • Publisher
      文光堂
    • Related Report
      2016 Research-status Report
  • [Book] 脳腫瘍の部位別発症頻度と問題点, 脳腫瘍学 日本臨床 2016年9月増刊号2016

    • Author(s)
      武笠晃丈、田中將太、斉藤延人
    • Total Pages
      5
    • Publisher
      日本臨床社
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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