| Project/Area Number |
16K15650
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小野寺 智洋 北海道大学, 大学病院, 講師 (70547174)
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| Research Collaborator |
HOMAN Kentaro 北海道大学, 大学院医学研究院, 博士研究員 (40823331)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨・軟骨代謝 / 糖鎖 / 骨・軟骨代謝学 |
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| Outline of Final Research Achievements |
Our hypothesis was that early osteoarthritic cahnges induced by alterations in cartilage glycans would be reversible. To test this hypothesis, we created in vivo and in vitro early osteoarthritic models based on alpha-mannosidase administration. The administration of alpha-mannosidase induced early osteoarthritis in in vivo and in vitro models. Additionally, this histological changes were recovered by the discontinuation of alpha-mannosidase adminiatrations. Future studies will be performed to clarify this recovery mechanism in early osteoarthritis pathogenesis.
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