Cerebrospinal Fluid Biomarkers for Lumbar Spinal Stenosis Identified by an Exhaustive search with High-Resolution Mass Spectrometry
| Project/Area Number |
16K15653
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
早川 謙太郎 東京大学, 医学部附属病院, 登録診療員 (20770697)
大出 晃士 東京大学, 大学院医学系研究科(医学部), 助教 (40612122)
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
|
|---|
| Keywords | バイオマーカー / 脊椎脊髄疾患 / プロテオーム / 脊椎脊髄病学 |
|---|
| Outline of Final Research Achievements |
We sought to identify proteins whose levels in the CSF in lumbar spinal stenosis patients were significantly different from those in the control group by performing an exhaustive search with high-resolution mass spectrometry. Further validation using an independent sample identified 7 proteins. These proteins may be utilized as bio-markers for lumbar spinal stenosis.
|
| Academic Significance and Societal Importance of the Research Achievements |
超高齢社会の日本において、高齢者に多くみられる腰部脊柱管狭窄症の病態解明および適切な診断・治療は極めて重要である。腰部脊柱管狭窄症を脳脊髄液中バイオマーカーにより客観的・定量的に評価する方法を確立することによって、腰部脊柱管狭窄症の病態解明や早期診断および治療効果の正確な評価等に寄与することができる。
|
Report
(4 results)
Research Products
(1 results)
